{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:34:16Z","timestamp":1789760056950,"version":"4.0.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1136\/ard.2009.109355","type":"journal-article","created":{"date-parts":[[2009,6,16]],"date-time":"2009-06-16T00:12:44Z","timestamp":1245111164000},"page":"1602-1608","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":136,"title":["Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis"],"prefix":"10.1016","volume":"68","author":[{"given":"R","family":"Torres","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Macdonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S D","family":"Croll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Reinhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Dore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D M","family":"Hylton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J S","family":"Rudge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Liu-Bryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R A","family":"Terkeltaub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G D","family":"Yancopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1136\/ard.2009.109355_bib1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/ar1906","article-title":"A concise history of gout and hyperuricemia and their treatment","volume":"8","author":"Nuki","year":"2006","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"10.1136\/ard.2009.109355_bib2","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/ar1908","article-title":"The inflammatory process of gout and its treatment","volume":"8","author":"Cronstein","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1136\/ard.2009.109355_bib3","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1093\/rheumatology\/keh640","article-title":"Mechanisms of inflammation in gout","volume":"44","author":"Dalbeth","year":"2005","journal-title":"Rheumatology (Oxford)"},{"key":"10.1136\/ard.2009.109355_bib4","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.2174\/138161205774913318","article-title":"Overview of hyperuricaemia and gout","volume":"11","author":"Masseoud","year":"2005","journal-title":"Curr Pharm Des"},{"key":"10.1136\/ard.2009.109355_bib5","first-page":"82","article-title":"Gout in 2006: the perfect storm","volume":"64","author":"Terkeltaub","year":"2006","journal-title":"Bull NYU Hosp Jt Dis"},{"key":"10.1136\/ard.2009.109355_bib6","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/art.1780280911","article-title":"Crystal-induced endogenous pyrogen production. A further look at gouty inflammation","volume":"28","author":"Malawista","year":"1985","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2009.109355_bib7","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.4049\/jimmunol.138.10.3213","article-title":"Interleukin 1 (IL 1) as a mediator of crystal arthritis. Stimulation of T cell and synovial fibroblast mitogenesis by urate crystal-induced IL 1","volume":"138","author":"Di Giovine","year":"1987","journal-title":"J Immunol"},{"key":"10.1136\/ard.2009.109355_bib8","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1074-7613(04)00046-9","article-title":"NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder","volume":"20","author":"Agostini","year":"2004","journal-title":"Immunity"},{"key":"10.1136\/ard.2009.109355_bib9","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"10.1136\/ard.2009.109355_bib10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/sj.cdd.4402038","article-title":"Inflammatory caspases and inflammasomes: master switches of inflammation","volume":"14","author":"Martinon","year":"2007","journal-title":"Cell Death Differ"},{"key":"10.1136\/ard.2009.109355_bib11","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1172\/JCI28075","article-title":"MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals","volume":"116","author":"Chen","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1136\/ard.2009.109355_bib12","doi-asserted-by":"crossref","first-page":"R28","DOI":"10.1186\/ar2143","article-title":"A pilot study of IL-1 inhibition by anakinra in acute gout","volume":"9","author":"So","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"10.1136\/ard.2009.109355_bib13","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1002\/art.21238","article-title":"Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation","volume":"52","author":"Liu-Bryan","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2009.109355_bib14","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nm811","article-title":"Cytokine traps: multi-component, high-affinity blockers of cytokine action","volume":"9","author":"Economides","year":"2003","journal-title":"Nat Med"},{"key":"10.1136\/ard.2009.109355_bib15","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.pain.2007.01.036","article-title":"Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses","volume":"130","author":"Torres","year":"2007","journal-title":"Pain"},{"key":"10.1136\/ard.2009.109355_bib16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/path.1711340205","article-title":"The formation of a structure with the features of synovial lining by subcutaneous injection of air: an in vivo tissue culture system","volume":"134","author":"Edwards","year":"1981","journal-title":"J Pathol"},{"key":"10.1136\/ard.2009.109355_bib17","first-page":"974","article-title":"The acute phase response in gout","volume":"14","author":"Roseff","year":"1987","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2009.109355_bib18","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1096\/fj.06-6339com","article-title":"Melanocortin 3 receptors control crystal-induced inflammation","volume":"20","author":"Getting","year":"2006","journal-title":"FASEB J"},{"key":"10.1136\/ard.2009.109355_bib19","first-page":"559","article-title":"Analysis of the cytokine network among tumor necrosis factor alpha, interleukin-1beta, interleukin-8, and interleukin-1 receptor antagonist in monosodium urate crystal-induced rabbit arthritis","volume":"78","author":"Matsukawa","year":"1998","journal-title":"Lab Invest"},{"key":"10.1136\/ard.2009.109355_bib20","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0304-3959(87)90072-8","article-title":"Ankle joint urate arthritis (AJUA) in rats: an alternative animal model of arthritis to that produced by Freund\u2019s adjuvant","volume":"28","author":"Coderre","year":"1987","journal-title":"Pain"},{"key":"10.1136\/ard.2009.109355_bib21","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0091-3057(88)90004-4","article-title":"Ankle joint urate arthritis in rats provides a useful tool for the evaluation of analgesic and anti-arthritic agents","volume":"29","author":"Coderre","year":"1988","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1136\/ard.2009.109355_bib22","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0165-1218(89)90093-1","article-title":"Micronucleus test with colchicine given by intraperitoneal injection and oral gavage","volume":"223","author":"Asano","year":"1989","journal-title":"Mutat Res"},{"key":"10.1136\/ard.2009.109355_bib23","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S0022-3565(25)29282-5","article-title":"Inhibition of sodium urate-induced rat hindpaw edema by colchicine derivatives: correlation with antimitotic activity","volume":"182","author":"Zweig","year":"1972","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1136\/ard.2009.109355_bib24","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/ki.1994.367","article-title":"Role of protein kinase pathways in IL-1-induced chemoattractant expression by human mesangial cells","volume":"46","author":"Rovin","year":"1994","journal-title":"Kidney Int"},{"issue":"(","key":"10.1136\/ard.2009.109355_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-5728(03)00251-0","article-title":"Cytokine regulation of MCP-1 expression in brain and retinal microvascular endothelial cells","volume":"142","author":"Harkness","year":"2003","journal-title":"J Neuroimmunol"},{"key":"10.1136\/ard.2009.109355_bib26","doi-asserted-by":"crossref","first-page":"5309","DOI":"10.4049\/jimmunol.170.10.5309","article-title":"Expression and production of the CXC chemokine growth-related oncogene-alpha by human eosinophils","volume":"170","author":"Persson-Dajotoy","year":"2003","journal-title":"J Immunol"},{"key":"10.1136\/ard.2009.109355_bib27","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.brainresrev.2008.12.020","article-title":"Role of Interleukin-1 beta during pain and inflammation","volume":"60","author":"Ren","year":"2009","journal-title":"Brain Res Rev"},{"key":"10.1136\/ard.2009.109355_bib28","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.neulet.2008.03.052","article-title":"Effect of cytokines on neuronal excitability","volume":"437","author":"Schafers","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1136\/ard.2009.109355_bib29","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1002\/art.23620","article-title":"A pilot study to evaluate the safety and efficacy of the long-acting interleukin-1 inhibitor rilonacept (interleukin-1 Trap) in patients with familial cold autoinflammatory syndrome","volume":"58","author":"Goldbach-Mansky","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2009.109355_bib30","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1002\/art.23687","article-title":"Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies","volume":"58","author":"Hoffman","year":"2008","journal-title":"Arthritis Rheum"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724216289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724216289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.2009.109355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T04:42:12Z","timestamp":1739162532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724216289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S0003496724216289"],"URL":"https:\/\/doi.org\/10.1136\/ard.2009.109355","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.2009.109355","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 United States & Canadian Academy of Pathology. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}