{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T05:35:45Z","timestamp":1771997745299,"version":"3.50.1"},"reference-count":18,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1136\/ard.2009.114934","type":"journal-article","created":{"date-parts":[[2009,9,5]],"date-time":"2009-09-05T00:13:04Z","timestamp":1252109584000},"page":"1471-1474","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["A CLEC16A variant confers risk for juvenile idiopathic arthritis and anti-cyclic citrullinated peptide antibody negative rheumatoid arthritis"],"prefix":"10.1016","volume":"69","author":[{"given":"Beate","family":"Skinningsrud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedicte A","family":"Lie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eystein S","family":"Husebye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tore K","family":"Kvien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d8ystein","family":"F\u00f8rre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berit","family":"Flat\u00f8","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Stormyr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geir","family":"Joner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e5l R","family":"Nj\u00f8lstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thore","family":"Egeland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dag E","family":"Undlien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1136\/ard.2009.114934_bib1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nature06010","article-title":"A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene","volume":"448","author":"Hakonarson","year":"2007","journal-title":"Nature"},{"key":"10.1136\/ard.2009.114934_bib2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature05911","article-title":"Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls","volume":"447","author":"The Wellcome Trust Case Control Consortium","year":"2007","journal-title":"Nature"},{"key":"10.1136\/ard.2009.114934_bib3","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1056\/NEJMoa073493","article-title":"Risk alleles for multiple sclerosis identified by a genomewide study","volume":"357","author":"Hafler","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1136\/ard.2009.114934_bib4","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/ng2068","article-title":"Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes","volume":"39","author":"Todd","year":"2007","journal-title":"Nat Genet"},{"key":"10.1136\/ard.2009.114934_bib5","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1210\/jc.2008-0821","article-title":"Polymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency","volume":"93","author":"Skinningsrud","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1136\/ard.2009.114934_bib6","article-title":"Chromosomal region 16p13: further evidence of increased predisposition to immune diseases","author":"Mart\u00ednez","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2009.114934_bib7","unstructured":"R Development Core Team. http:\/\/www.R-project.org, (accessed 2 March 2009)."},{"key":"10.1136\/ard.2009.114934_bib8","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"10.1136\/ard.2009.114934_bib9","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000119108","article-title":"Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data","volume":"66","author":"Dudbridge","year":"2008","journal-title":"Hum Hered"},{"key":"10.1136\/ard.2009.114934_bib10","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1210\/jc.2008-0718","article-title":"Association of type 1 diabetes with two Loci on 12q13 and 16p13 and the influence coexisting thyroid autoimmunity in Japanese","volume":"94","author":"Awata","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1136\/ard.2009.114934_bib11","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/gene.2008.59","article-title":"Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians","volume":"9","author":"Rubio","year":"2008","journal-title":"Genes Immun"},{"key":"10.1136\/ard.2009.114934_bib12","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1365-2265.2008.03437.x","article-title":"Intron polymorphism in the KIAA0350 gene is reproducibly associated with susceptibility to type 1 diabetes (T1D) in the Han Chinese population","volume":"71","author":"Wu","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1136\/ard.2009.114934_bib13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/gene.2008.84","article-title":"Variation within the CLEC16A gene shows consistent disease association with both multiple sclerosis and type 1 diabetes in Sardinia","volume":"10","author":"Zoledziewska","year":"2009","journal-title":"Genes Immun"},{"key":"10.1136\/ard.2009.114934_bib14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/gene.2008.83","article-title":"The expanding genetic overlap between multiple sclerosis and type I diabetes","volume":"10","author":"International Multiple Sclerosis Genetics Consortium","year":"2009","journal-title":"Genes Immun"},{"key":"10.1136\/ard.2009.114934_bib15","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/ejhg.2009.50","article-title":"Specific association of a CLEC16A\/KIAA0350 polymorphism with NOD2\/CARD15(-) Crohn's disease patients","volume":"17","author":"M\u00e1rquez","year":"2009","journal-title":"Eur J Hum Genet"},{"key":"10.1136\/ard.2009.114934_bib16","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1002\/art.21419","article-title":"Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: contrasting effects of HLA-DR3 and the shared epitope alleles","volume":"52","author":"Irigoyen","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2009.114934_bib17","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1086\/498651","article-title":"Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4 and PADI4","volume":"77","author":"Plenge","year":"2005","journal-title":"Am J Hum Genet"},{"key":"10.1136\/ard.2009.114934_bib18","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1002\/art.22704","article-title":"Association of a haplotype in the promoter region of the interfseron regulatory factor 5 gene with rheumatoid arthritis","volume":"56","author":"Sigurdsson","year":"2007","journal-title":"Arthritis Rheum"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724193909?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724193909?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.2009.114934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T14:05:17Z","timestamp":1736085917000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724193909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0003496724193909"],"URL":"https:\/\/doi.org\/10.1136\/ard.2009.114934","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A CLEC16A variant confers risk for juvenile idiopathic arthritis and anti-cyclic citrullinated peptide antibody negative rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.2009.114934","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Published by Elsevier Inc. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}