{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T12:15:40Z","timestamp":1784722540897,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1136\/ard.2009.125534","type":"journal-article","created":{"date-parts":[[2010,5,6]],"date-time":"2010-05-06T00:31:51Z","timestamp":1273105911000},"page":"1789-1795","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":164,"title":["Radiographic progression and remission rates in early rheumatoid arthritis \u2013 MRI bone oedema and anti-CCP predicted radiographic progression in the 5-year extension of the double-blind randomised CIMESTRA trial"],"prefix":"10.1016","volume":"69","author":[{"given":"Merete L","family":"Hetland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Stengaard-Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Junker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel","family":"\u00d8stergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo J","family":"Ejbjerg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Jacobsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tine","family":"Lottenburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ib","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrik","family":"Tarp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lis S","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Svendsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens K","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrik B","family":"Lauridsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torkell","family":"Ellingsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Lindegaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"P\u00f8denphant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aage","family":"Vestergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Grethe","family":"Jurik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"H\u00f8rslev-Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1136\/ard.2009.125534_bib1","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1002\/art.21796","volume":"54","author":"Hetland","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2009.125534_bib2","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1136\/ard.2007.076307","article-title":"Aggressive combination therapy with intra-articular glucocorticoid injections and conventional disease-modifying anti-rheumatic drugs in early rheumatoid arthritis: second-year clinical and radiographic results from the CIMESTRA study","volume":"67","author":"Hetland","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2009.125534_bib3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/art.11436","article-title":"Impact of initial aggressive drug treatment with a combination of disease-modifying antirheumatic drugs on the development of work disability in early rheumatoid arthritis: a five-year randomized followup trial","volume":"50","author":"Puolakka","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2009.125534_bib4","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0140-6736(97)01300-7","article-title":"Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis","volume":"350","author":"Boers","year":"1997","journal-title":"Lancet"},{"key":"10.1136\/ard.2009.125534_bib5","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1002\/1529-0131(200008)43:8<1809::AID-ANR17>3.0.CO;2-D","article-title":"Treatment of poor-prognosis early rheumatoid arthritis. A randomized study of treatment with methotrexate, cyclosporin A, and intraarticular corticosteroids compared with sulfasalazine alone","volume":"43","author":"Proudman","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2009.125534_bib6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/art.10083","article-title":"COBRA combination therapy in patients with early rheumatoid arthritis: long-term structural benefits of a brief intervention","volume":"46","author":"Landew\u00e9","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2009.125534_bib7","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1002\/art.20351","article-title":"Retardation of joint damage in patients with early rheumatoid arthritis by initial aggressive treatment with disease-modifying antirheumatic drugs: five-year experience from the FIN-RACo study","volume":"50","author":"Korpela","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2009.125534_bib8","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1136\/ard.2008.093294","article-title":"Clinical and radiological efficacy of initial vs delayed treatment with infliximab plus methotrexate in patients with early rheumatoid arthritis","volume":"68","author":"van der Kooij","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2009.125534_bib9","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1136\/ard.62.8.764","article-title":"Long term structural effects of combination therapy in patients with early rheumatoid arthritis: five year follow up of a prospective double blind controlled study","volume":"62","author":"Maillefert","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2009.125534_bib10","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1136\/ard.58.4.220","article-title":"Combination therapy in early rheumatoid arthritis: a randomised, controlled, double blind 52 week clinical trial of sulphasalazine and methotrexate compared with the single components","volume":"58","author":"Dougados","year":"1999","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2009.125534_bib11","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/art.21620","article-title":"Treatment of early seropositive rheumatoid arthritis: doxycycline plus methotrexate versus methotrexate alone","volume":"54","author":"O'Dell","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2009.125534_bib12","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1136\/ard.2008.088245","article-title":"MRI bone oedema is the strongest predictor of subsequent radiographic progression in early rheumatoid arthritis. Results from a 2-year randomised controlled trial (CIMESTRA)","volume":"68","author":"Hetland","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2009.125534_bib13","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2009.125534_bib14","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/art.10181","article-title":"How to report radiographic data in randomized clinical trials in rheumatoid arthritis: guidelines from a roundtable discussion","volume":"47","author":"van der Heijde","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2009.125534_bib15","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1148\/85.2.325","article-title":"Earliest roentgenological changes in polyarthritis of the rheumatoid type: rheumatoid arthritis","volume":"85","author":"Norgaard","year":"1965","journal-title":"Radiology"},{"key":"10.1136\/ard.2009.125534_bib16","first-page":"743","article-title":"How to read radiographs according to the Sharp\/van der Heijde method","volume":"26","author":"van der Heijde","year":"1999","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2009.125534_bib17","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1056\/NEJM200011303432201","article-title":"A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis","volume":"343","author":"Bathon","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1136\/ard.2009.125534_bib18","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1002\/art.1780241012","article-title":"Preliminary criteria for clinical remission in rheumatoid arthritis","volume":"24","author":"Pinals","year":"1981","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2009.125534_bib19","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/art.1780380107","article-title":"Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis","volume":"38","author":"Prevoo","year":"1995","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2009.125534_bib20","doi-asserted-by":"crossref","first-page":"797","DOI":"10.7326\/0003-4819-146-11-200706050-00008","article-title":"Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis","volume":"146","author":"Nishimura","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.1136\/ard.2009.125534_bib21","first-page":"1385","article-title":"OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Studies. Core set of MRI acquisitions, joint pathology definitions, and the OMERACT RA-MRI scoring system","volume":"30","author":"\u00d8stergaard","year":"2003","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2009.125534_bib22","unstructured":"R Development Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing, 2006. ISBN 3-900051-07-0. http:\/\/www.R-project.org."},{"key":"10.1136\/ard.2009.125534_bib23","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0140-6736(09)61432-X","article-title":"Rheumatoid arthritis: strategy more important than agent","volume":"374","author":"Sokka","year":"2009","journal-title":"Lancet"},{"key":"10.1136\/ard.2009.125534_bib24","doi-asserted-by":"crossref","first-page":"406","DOI":"10.7326\/0003-4819-146-6-200703200-00005","article-title":"Comparison of treatment strategies in early rheumatoid arthritis: a randomized trial","volume":"146","author":"Goekoop-Ruiterman","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.1136\/ard.2009.125534_bib25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/art.10731","article-title":"Functional disability in rheumatoid arthritis patients compared with a community population in Finland","volume":"48","author":"Sokka","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2009.125534_bib26","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/art.21519","volume":"54","author":"Breedveld","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2009.125534_bib27","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1002\/art.10308","article-title":"Etanercept versus methotrexate in patients with early rheumatoid arthritis: two-year radiographic and clinical outcomes","volume":"46","author":"Genovese","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2009.125534_bib28","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0140-6736(08)61000-4","article-title":"Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): a randomised, double-blind, parallel treatment trial","volume":"372","author":"Emery","year":"2008","journal-title":"Lancet"},{"key":"10.1136\/ard.2009.125534_bib29","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1056\/NEJM199507203330301","article-title":"Combination therapy with cyclosporine and methotrexate in severe rheumatoid arthritis. The Methotrexate-Cyclosporine Combination Study Group","volume":"333","author":"Tugwell","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1136\/ard.2009.125534_bib30","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1093\/rheumatology\/keg394","article-title":"Radiographic progression in early rheumatoid arthritis: a 12-month randomized controlled study comparing the combination of cyclosporin and methotrexate with methotrexate alone","volume":"42","author":"Marchesoni","year":"2003","journal-title":"Rheumatology (Oxford)"},{"key":"10.1136\/ard.2009.125534_bib31","first-page":"2077","article-title":"Combination therapy with methotrexate and hydroxychloroquine for rheumatoid arthritis increases exposure to methotrexate","volume":"29","author":"Carmichael","year":"2002","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2009.125534_bib32","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1002\/art.11162","article-title":"Bone edema scored on magnetic resonance imaging scans of the dominant carpus at presentation predicts radiographic joint damage of the hands and feet six years later in patients with rheumatoid arthritis","volume":"48","author":"McQueen","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2009.125534_bib33","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00296-003-0404-2","article-title":"Synovial membrane enhancement and bone erosion by magnetic resonance imaging for prediction of radiologic progression in patients with early rheumatoid arthritis","volume":"25","author":"Tanaka","year":"2005","journal-title":"Rheumatol Int"},{"key":"10.1136\/ard.2009.125534_bib34","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1136\/ard.2009.113092","article-title":"Prediction of radiographic progression in rheumatoid arthritis and the role of antibodies against mutated citrullinated vimentin: results from a 10-year prospective study","volume":"69","author":"Syversen","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2009.125534_bib35","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0140-6736(04)16676-2","article-title":"Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial","volume":"364","author":"Grigor","year":"2004","journal-title":"Lancet"},{"key":"10.1136\/ard.2009.125534_bib36","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1136\/ard.2007.071092","article-title":"Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial)","volume":"66","author":"Verstappen","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2009.125534_bib37","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1002\/art.21405","article-title":"Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial","volume":"52","author":"Goekoop-Ruiterman","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2009.125534_bib38","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1136\/ard.2006.057133","article-title":"Combination therapy with sulfasalazine and methotrexate is more effective than either drug alone in patients with rheumatoid arthritis with a suboptimal response to sulfasalazine: results from the double-blind placebo-controlled MASCOT study","volume":"66","author":"Capell","year":"2007","journal-title":"Ann Rheum Dis"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724148194?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724148194?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.2009.125534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T05:30:56Z","timestamp":1737437456000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724148194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0003496724148194"],"URL":"https:\/\/doi.org\/10.1136\/ard.2009.125534","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Radiographic progression and remission rates in early rheumatoid arthritis \u2013 MRI bone oedema and anti-CCP predicted radiographic progression in the 5-year extension of the double-blind randomised CIMESTRA trial","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.2009.125534","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Published by Elsevier Inc. For permission to use (where not already granted under a licence) please go to http:\/\/group.bmj.com\/group\/rights-licensing\/permissions. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}