{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:28:52Z","timestamp":1789993732679,"version":"4.0.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1136\/ard.2010.135509","type":"journal-article","created":{"date-parts":[[2010,11,11]],"date-time":"2010-11-11T01:59:59Z","timestamp":1289440799000},"page":"373-379","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["Anti-citrullinated protein antibodies have a low avidity compared with antibodies against recall antigens"],"prefix":"10.1016","volume":"70","author":[{"given":"P","family":"Suwannalai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H U","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"van der Woude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ioan-Facsinay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C M","family":"Jol-van der Zijde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J D","family":"van Tol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J W","family":"Drijfhout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T W J","family":"Huizinga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R E M","family":"Toes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L A","family":"Trouw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1136\/ard.2010.135509_bib1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/08916930400022582","article-title":"Autoantibodies to citrullinated proteins: ACPA","volume":"38","author":"Vincent","year":"2005","journal-title":"Autoimmunity"},{"key":"10.1136\/ard.2010.135509_bib2","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1146\/annurev.immunol.26.021607.090244","article-title":"Immunity to citrullinated proteins in rheumatoid arthritis","volume":"26","author":"Klareskog","year":"2008","journal-title":"Annu Rev Immunol"},{"key":"10.1136\/ard.2010.135509_bib3","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1002\/1529-0131(200008)43:8<1831::AID-ANR19>3.0.CO;2-6","article-title":"The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritis","volume":"43","author":"Kroot","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.135509_bib4","doi-asserted-by":"crossref","first-page":"R949","DOI":"10.1186\/ar1767","article-title":"Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis","volume":"7","author":"van der Helm-van Mil","year":"2005","journal-title":"Arthritis Res Ther"},{"key":"10.1136\/ard.2010.135509_bib5","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/art.20018","article-title":"Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors","volume":"50","author":"Nielen","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.135509_bib6","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1172\/JCI25422","article-title":"Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis","volume":"116","author":"Kuhn","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1136\/ard.2010.135509_bib7","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1084\/jem.20081862","article-title":"Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis","volume":"206","author":"Uysal","year":"2009","journal-title":"J Exp Med"},{"key":"10.1136\/ard.2010.135509_bib8","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/art.23284","article-title":"Induction of macrophage secretion of tumor necrosis factor alpha through Fcgamma receptor IIa engagement by rheumatoid arthritis-specific autoantibodies to citrullinated proteins complexed with fibrinogen","volume":"58","author":"Clavel","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.135509_bib9","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1002\/art.24622","article-title":"Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways","volume":"60","author":"Trouw","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.135509_bib10","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/02724936.2000.11748153","article-title":"Levels and avidity of antibodies to tetanus toxoid in children aged 1\u201315 years in Dar es Salaam and Bagamoyo, Tanzania","volume":"20","author":"Aboud","year":"2000","journal-title":"Ann Trop Paediatr"},{"key":"10.1136\/ard.2010.135509_bib11","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1128\/IAI.67.5.2366-2370.1999","article-title":"Avidity as a determinant of the protective efficacy of human antibodies to pneumococcal capsular polysaccharides","volume":"67","author":"Usinger","year":"1999","journal-title":"Infect Immun"},{"key":"10.1136\/ard.2010.135509_bib12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1086\/338259","article-title":"Concentration and avidity of anti-Haemophilus influenzae type b (Hib) antibodies in serum samples obtained from patients for whom Hib vaccination failed","volume":"34","author":"Breukels","year":"2002","journal-title":"Clin Infect Dis"},{"key":"10.1136\/ard.2010.135509_bib13","doi-asserted-by":"crossref","first-page":"4658","DOI":"10.1073\/pnas.1001074107","article-title":"Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis","volume":"107","author":"Huang","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1136\/ard.2010.135509_bib14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1136\/ard.2005.038471","article-title":"Comparison of long term outcome of patients with rheumatoid arthritis presenting with undifferentiated arthritis or with rheumatoid arthritis: an observational cohort study","volume":"65","author":"van Aken","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2010.135509_bib15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0022-1759(86)90268-1","article-title":"Antibody avidity determination by ELISA using thiocyanate elution","volume":"86","author":"Pullen","year":"1986","journal-title":"J Immunol Methods"},{"key":"10.1136\/ard.2010.135509_bib16","series-title":"Immunochemistry II: A Practical Approach","first-page":"31","article-title":"Simple solid phase assays of avidity","author":"Goldblatt","year":"1997"},{"key":"10.1136\/ard.2010.135509_bib17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/jcla.20172","article-title":"Improved method to calculate the antibody avidity index","volume":"21","author":"Perciani","year":"2007","journal-title":"J Clin Lab Anal"},{"key":"10.1136\/ard.2010.135509_bib18","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/j.1365-2249.2004.02708.x","article-title":"IgG subclass distribution of the rheumatoid arthritis-specific autoantibodies to citrullinated fibrin","volume":"139","author":"Chapuy-Regaud","year":"2005","journal-title":"Clin Exp Immunol"},{"key":"10.1136\/ard.2010.135509_bib19","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1128\/CDLI.6.3.352-355.1999","article-title":"Immunoglobulin G (IgG) subclass distribution and IgG1 avidity of antibodies in human immunodeficiency virus-infected individuals after revaccination with tetanus toxoid","volume":"6","author":"Kroon","year":"1999","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1136\/ard.2010.135509_bib20","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/BF01719348","article-title":"Long-term persistence of anti-diphtheria toxin antibodies among adults in Israel. Implications for vaccine policy","volume":"10","author":"Cohen","year":"1994","journal-title":"Eur J Epidemiol"},{"key":"10.1136\/ard.2010.135509_bib21","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1002\/art.22279","article-title":"Isotype distribution of anti-cyclic citrullinated peptide antibodies in undifferentiated arthritis and rheumatoid arthritis reflects an ongoing immune response","volume":"54","author":"Verpoort","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.135509_bib22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/ar2903","article-title":"The use of citrullinated peptides and proteins for the diagnosis of rheumatoid arthritis","volume":"12","author":"Pruijn","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"10.1136\/ard.2010.135509_bib23","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1002\/art.22817","article-title":"Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis","volume":"56","author":"Bang","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.135509_bib24","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.4049\/jimmunol.166.6.4177","article-title":"The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrin","volume":"166","author":"Masson-Bessi\u00e8re","year":"2001","journal-title":"J Immunol"},{"key":"10.1136\/ard.2010.135509_bib25","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1136\/ard.2008.091355","article-title":"Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: association with HLA-DRB1 alleles","volume":"68","author":"Snir","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2010.135509_bib26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1084\/jem.132.1.77","article-title":"Studies on the regulation of avidity at the level of the single antibody-forming cell. The effect of antigen dose and time after immunization","volume":"132","author":"Andersson","year":"1970","journal-title":"J Exp Med"},{"key":"10.1136\/ard.2010.135509_bib27","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1073\/pnas.0913054107","article-title":"Evidence for a functional role of IgE anticitrullinated protein antibodies in rheumatoid arthritis","volume":"107","author":"Schuerwegh","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1136\/ard.2010.135509_bib28","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/361541a0","article-title":"CD40 ligand mutations in x-linked immunodeficiency with hyper-IgM","volume":"361","author":"DiSanto","year":"1993","journal-title":"Nature"},{"key":"10.1136\/ard.2010.135509_bib29","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/361539a0","article-title":"Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM","volume":"361","author":"Korth\u00e4uer","year":"1993","journal-title":"Nature"},{"key":"10.1136\/ard.2010.135509_bib30","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/art.21739","article-title":"The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis","volume":"54","author":"van der Helm-van Mil","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.135509_bib31","doi-asserted-by":"crossref","first-page":"547","DOI":"10.4049\/jimmunol.171.2.547","article-title":"Cutting edge: germinal centers formed in the absence of B cell-activating factor belonging to the TNF family exhibit impaired maturation and function","volume":"171","author":"Vora","year":"2003","journal-title":"J Immunol"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724146882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724146882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.2010.135509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T23:58:36Z","timestamp":1737244716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724146882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0003496724146882"],"URL":"https:\/\/doi.org\/10.1136\/ard.2010.135509","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-citrullinated protein antibodies have a low avidity compared with antibodies against recall antigens","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.2010.135509","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Published by Elsevier Inc. For permission to use (where not already granted under a licence) please go to http:\/\/group.bmj.com\/group\/rights-licensing\/permissions. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}