{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:09:33Z","timestamp":1790831373445,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1136\/ard.2010.143347","type":"journal-article","created":{"date-parts":[[2011,5,30]],"date-time":"2011-05-30T00:13:33Z","timestamp":1306714413000},"page":"1605-1612","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":204,"title":["Aggressive Combination Drug Therapy in Very Early Polyarticular Juvenile Idiopathic Arthritis (ACUTE\u2013JIA): a multicentre randomised open-label clinical trial"],"prefix":"10.1016","volume":"70","author":[{"given":"Pirjo","family":"Tynj\u00e4l\u00e4","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"V\u00e4h\u00e4salo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarit","family":"Tarkiainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liisa","family":"Kr\u00f6ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristiina","family":"Aalto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merja","family":"Malin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Putto-Laurila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Visa","family":"Honkanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pekka","family":"Lahdenne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1136\/ard.2010.143347_bib1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0140-6736(07)60363-8","article-title":"Juvenile idiopathic arthritis.","volume":"369","author":"Ravelli","year":"2007","journal-title":"Lancet"},{"key":"10.1136\/ard.2010.143347_bib2","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001.","volume":"31","author":"Petty","year":"2004","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2010.143347_bib3","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1002\/art.21389","article-title":"Patterns of clinical remission in select categories of juvenile idiopathic arthritis.","volume":"52","author":"Wallace","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.143347_bib4","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1002\/art.22181","article-title":"Long-term outcome and prognostic factors in enthesitis-related arthritis: a case\u2013control study.","volume":"54","author":"Flat\u00f8","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.143347_bib5","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/rheumatology\/39.2.198","article-title":"Juvenile chronic arthritis into adulthood: a long-term follow-up study.","volume":"39","author":"Zak","year":"2000","journal-title":"Rheumatology (Oxford)"},{"key":"10.1136\/ard.2010.143347_bib6","first-page":"394","article-title":"Health status of patients with juvenile rheumatoid arthritis at 1 and 5 years after diagnosis.","volume":"30","author":"Bowyer","year":"2003","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2010.143347_bib7","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1136\/ard.2007.073445","article-title":"The magnitude of early response to methotrexate therapy predicts long-term outcome of patients with juvenile idiopathic arthritis.","volume":"67","author":"Bartoli","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2010.143347_bib8","doi-asserted-by":"crossref","first-page":"628","DOI":"10.3899\/jrheum.080560","article-title":"Achievement of a state of inactive disease at least once in the first 5 years predicts better outcome of patients with polyarticular juvenile idiopathic arthritis.","volume":"36","author":"Magnani","year":"2009","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2010.143347_bib9","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1056\/NEJM199204163261602","article-title":"Methotrexate in resistant juvenile rheumatoid arthritis. Results of the U.S.A.\u2013U.S.S.R. double-blind, placebo-controlled trial. The Pediatric Rheumatology Collaborative Study Group and The Cooperative Children's Study Group.","volume":"326","author":"Giannini","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1136\/ard.2010.143347_bib10","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1002\/art.20288","article-title":"A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate.","volume":"50","author":"Ruperto","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.143347_bib11","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1056\/NEJMoa041810","article-title":"Leflunomide or methotrexate for juvenile rheumatoid arthritis.","volume":"352","author":"Silverman","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1136\/ard.2010.143347_bib12","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1002\/1529-0131(199805)41:5<808::AID-ART6>3.0.CO;2-T","article-title":"Sulfasalazine in the treatment of juvenile chronic arthritis: a randomized, double-blind, placebo-controlled, multicenter study. Dutch Juvenile Chronic Arthritis Study Group.","volume":"41","author":"van Rossum","year":"1998","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.143347_bib13","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1016\/S0140-6736(98)08513-4","article-title":"Comparison of combination therapy with single-drug therapy in early rheumatoid arthritis: a randomised trial. FIN\u2013RACo trial group.","volume":"353","author":"M\u00f6tt\u00f6nen","year":"1999","journal-title":"Lancet"},{"key":"10.1136\/ard.2010.143347_bib14","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1002\/art.21405","article-title":"Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial.","volume":"52","author":"Goekoop-Ruiterman","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.143347_bib15","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1056\/NEJM200003163421103","article-title":"Etanercept in children with polyarticular juvenile rheumatoid arthritis. Pediatric Rheumatology Collaborative Study Group.","volume":"342","author":"Lovell","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1136\/ard.2010.143347_bib16","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1002\/art.22838","article-title":"A randomized, placebo-controlled trial of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis.","volume":"56","author":"Ruperto","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.143347_bib17","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1056\/NEJMoa0706290","article-title":"Adalimumab with or without methotrexate in juvenile rheumatoid arthritis.","volume":"359","author":"Lovell","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1136\/ard.2010.143347_bib18","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1002\/art.23427","article-title":"Safety and efficacy of up to eight years of continuous etanercept therapy in patients with juvenile rheumatoid arthritis.","volume":"58","author":"Lovell","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.143347_bib19","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/ar2619","article-title":"Recent developments in anti-rheumatic drugs in pediatrics: treatment of juvenile idiopathic arthritis.","volume":"11","author":"Hayward","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"10.1136\/ard.2010.143347_bib20","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1097\/BOR.0b013e32832f142e","article-title":"Theoretical and practical basis for early aggressive therapy in paediatric autoimmune disorders.","volume":"21","author":"Woo","year":"2009","journal-title":"Curr Opin Rheumatol"},{"key":"10.1136\/ard.2010.143347_bib21","unstructured":"Uses and Administration of Corticosteroids. Triamcinolone. In: Martindale: The Complete Drug Reference from the Royal Pharmaceutical Society of Great Britain. Micromedex Database. https:\/\/www.thomsonhc.com\/home\/dispatch\/PFDefaultActionId\/pf.LoginAction (accessed 23 March 2011)."},{"key":"10.1136\/ard.2010.143347_bib22","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1002\/1529-0131(199707)40:7<1202::AID-ART3>3.0.CO;2-R","article-title":"Preliminary definition of improvement in juvenile arthritis.","volume":"40","author":"Giannini","year":"1997","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.143347_bib23","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1136\/ard.2009.100354","article-title":"Long-term efficacy and safety of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis: findings from an open-label treatment extension.","volume":"69","author":"Ruperto","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2010.143347_bib24","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1136\/ard.62.3.245","article-title":"Infliximab or etanercept in the treatment of children with refractory juvenile idiopathic arthritis: an open label study.","volume":"62","author":"Lahdenne","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2010.143347_bib25","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/art.23916","article-title":"Development and validation of a preliminary definition of minimal disease activity in patients with juvenile idiopathic arthritis.","volume":"59","author":"Magni-Manzoni","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.143347_bib26","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/art.24477","article-title":"Disease control and health-related quality of life in juvenile idiopathic arthritis.","volume":"61","author":"Seid","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.143347_bib27","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/art.10135","article-title":"Delay to institution of therapy and induction of remission using single-drug or combination-disease-modifying antirheumatic drug therapy in early rheumatoid arthritis.","volume":"46","author":"M\u00f6tt\u00f6nen","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.143347_bib28","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.berh.2006.05.005","article-title":"Treating very early rheumatoid arthritis.","volume":"20","author":"Raza","year":"2006","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1136\/ard.2010.143347_bib29","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s100670200098","article-title":"Attained adult height in juvenile rheumatoid arthritis with or without corticosteroid treatment.","volume":"21","author":"Wang","year":"2002","journal-title":"Clin Rheumatol"},{"key":"10.1136\/ard.2010.143347_bib30","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1002\/art.23683","article-title":"Bone density, structure, and strength in juvenile idiopathic arthritis: importance of disease severity and muscle deficits.","volume":"58","author":"Burnham","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.143347_bib31","first-page":"2275","article-title":"Incidence of juvenile idiopathic arthritis in the Nordic countries. A population based study with special reference to the validity of the ILAR and EULAR criteria.","volume":"30","author":"Berntson","year":"2003","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2010.143347_bib32","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1002\/art.27511","article-title":"Tumor necrosis factor alpha blockers and malignancy in children: forty-eight cases reported to the Food and Drug Administration.","volume":"62","author":"Diak","year":"2010","journal-title":"Arthritis Rheum"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724191637?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724191637?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.2010.143347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T13:57:42Z","timestamp":1736085462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724191637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0003496724191637"],"URL":"https:\/\/doi.org\/10.1136\/ard.2010.143347","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aggressive Combination Drug Therapy in Very Early Polyarticular Juvenile Idiopathic Arthritis (ACUTE\u2013JIA): a multicentre randomised open-label clinical trial","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.2010.143347","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Published by Elsevier Inc. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}