{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:38:10Z","timestamp":1780472290666,"version":"3.54.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1136\/ard.2010.146191","type":"journal-article","created":{"date-parts":[[2011,4,23]],"date-time":"2011-04-23T00:44:52Z","timestamp":1303519492000},"page":"1395-1400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["Association of the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase gene with response to methotrexate in juvenile idiopathic arthritis"],"prefix":"10.1016","volume":"70","author":[{"given":"Anne","family":"Hinks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halima","family":"Moncrieffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Ursu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sham","family":"Lal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Kassoumeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey","family":"Weiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N","family":"Glass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan D","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy R","family":"Wedderburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1136\/ard.2010.146191_bib1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0140-6736(07)60363-8","article-title":"Juvenile idiopathic arthritis.","volume":"369","author":"Ravelli","year":"2007","journal-title":"Lancet"},{"key":"10.1136\/ard.2010.146191_bib2","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1002\/1529-0131(200008)43:8<1849::AID-ANR22>3.0.CO;2-F","article-title":"Randomized, placebo-controlled, crossover trial of low-dose oral methotrexate in children with extended oligoarticular or systemic arthritis.","volume":"43","author":"Woo","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.146191_bib3","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1002\/art.20288","article-title":"A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate.","volume":"50","author":"Ruperto","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.146191_bib4","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2217\/pgs.09.171","article-title":"Classical twin design in modern pharmacogenomics studies.","volume":"11","author":"Rahmioglu","year":"2010","journal-title":"Pharmacogenomics"},{"key":"10.1136\/ard.2010.146191_bib5","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nrg2751","article-title":"Genome-wide association studies in pharmacogenomics.","volume":"11","author":"Daly","year":"2010","journal-title":"Nat Rev Genet"},{"key":"10.1136\/ard.2010.146191_bib6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1136\/adc.88.3.197","article-title":"Use of methotrexate in juvenile idiopathic arthritis.","volume":"88","author":"Ramanan","year":"2003","journal-title":"Arch Dis Child"},{"key":"10.1136\/ard.2010.146191_bib7","first-page":"1832","article-title":"Influence of methylenetetrahydrofolate reductase polymorphisms on efficacy and toxicity of methotrexate in patients with juvenile idiopathic arthritis.","volume":"32","author":"Schmeling","year":"2005","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2010.146191_bib8","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/art.24087","article-title":"Time to treatment as an important factor for the response to methotrexate in juvenile idiopathic arthritis.","volume":"61","author":"Albers","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.146191_bib9","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001.","volume":"31","author":"Petty","year":"2004","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2010.146191_bib10","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1002\/1529-0131(199707)40:7<1202::AID-ART3>3.0.CO;2-R","article-title":"Preliminary definition of improvement in juvenile arthritis.","volume":"40","author":"Giannini","year":"1997","journal-title":"Arthritis Rheum"},{"issue":"4 Suppl 23","key":"10.1136\/ard.2010.146191_bib11","first-page":"S163","article-title":"The British version of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ).","volume":"19","author":"Nugent","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"10.1136\/ard.2010.146191_bib12","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps.","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1136\/ard.2010.146191_bib13","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses.","volume":"81","author":"Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"10.1136\/ard.2010.146191_bib14","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1136\/ard.2007.073445","article-title":"The magnitude of early response to methotrexate therapy predicts long-term outcome of patients with juvenile idiopathic arthritis.","volume":"67","author":"Bartoli","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2010.146191_bib15","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nature02214","article-title":"Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.","volume":"427","author":"Rost","year":"2004","journal-title":"Nature"},{"key":"10.1136\/ard.2010.146191_bib16","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(98)04474-2","article-title":"Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications.","volume":"353","author":"Aithal","year":"1999","journal-title":"Lancet"},{"key":"10.1136\/ard.2010.146191_bib17","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1001\/jama.287.13.1690","article-title":"Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy.","volume":"287","author":"Higashi","year":"2002","journal-title":"JAMA"},{"key":"10.1136\/ard.2010.146191_bib18","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1067\/mcp.2002.129321","article-title":"Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance.","volume":"72","author":"Scordo","year":"2002","journal-title":"Clin Pharmacol Ther"},{"key":"10.1136\/ard.2010.146191_bib19","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1182\/blood-2008-01-134247","article-title":"A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose.","volume":"112","author":"Cooper","year":"2008","journal-title":"Blood"},{"key":"10.1136\/ard.2010.146191_bib20","doi-asserted-by":"crossref","first-page":"e1000433","DOI":"10.1371\/journal.pgen.1000433","article-title":"A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.","volume":"5","author":"Takeuchi","year":"2009","journal-title":"PLoS Genet"},{"key":"10.1136\/ard.2010.146191_bib21","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.2217\/14622416.9.9.1195","article-title":"Pharmacogenetic relevance of MTHFR polymorphisms.","volume":"9","author":"Toffoli","year":"2008","journal-title":"Pharmacogenomics"},{"key":"10.1136\/ard.2010.146191_bib22","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1002\/art.20460","article-title":"Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis.","volume":"50","author":"Dervieux","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.146191_bib23","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/rheumatology\/ken513","article-title":"Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate.","volume":"48","author":"Lee","year":"2009","journal-title":"Rheumatology (Oxford)"},{"key":"10.1136\/ard.2010.146191_bib24","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1002\/art.22032","article-title":"Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis.","volume":"54","author":"Wessels","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"Suppl3","key":"10.1136\/ard.2010.146191_bib25","first-page":"53","article-title":"Polymorphism in the 5-aminoimidazole-4-carboxamide ribonucleoptide transformylase (ATIC) gene is associated with poor methotrexate efficacy in patients with rheumatoid arthritis.","volume":"39","author":"Milic","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2010.146191_bib26","first-page":"S579","article-title":"Genetic polymorphisms in key methotrexate (MTX) pathway genes associated with response to MTX treatment in rheumatoid arthritis.","volume":"62","author":"Owen","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2010.146191_bib27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrrheum.2010.5","article-title":"Methotrexate\u2013how does it really work?","volume":"6","author":"Chan","year":"2010","journal-title":"Nat Rev Rheumatol"},{"key":"10.1136\/ard.2010.146191_bib28","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/sj.tpj.6500035","article-title":"Integrating genotype and phenotype information: an overview of the PharmGKB project. Pharmacogenetics Research Network and Knowledge Base.","volume":"1","author":"Klein","year":"2001","journal-title":"Pharmacogenomics J"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724191911?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724191911?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.2010.146191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T13:58:40Z","timestamp":1736085520000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724191911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0003496724191911"],"URL":"https:\/\/doi.org\/10.1136\/ard.2010.146191","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase gene with response to methotrexate in juvenile idiopathic arthritis","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.2010.146191","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Published by Elsevier Inc. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}