{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T05:50:18Z","timestamp":1793512218108,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1136\/ard.2011.150243","type":"journal-article","created":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T20:26:04Z","timestamp":1311711964000},"page":"1804-1809","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":342,"title":["Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study"],"prefix":"10.1016","volume":"70","author":[{"given":"Frank W","family":"Roemer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Guermazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T","family":"Felson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C","family":"Nevitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel D","family":"Crema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cora E","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Torner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1136\/ard.2011.150243_bib1","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/art.24383","article-title":"Meniscal tear in knees without surgery and the development of radiographic osteoarthritis among middle-aged and elderly persons: The Multicenter Osteoarthritis Study.","volume":"60","author":"Englund","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2011.150243_bib2","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1136\/ard.2008.096834","article-title":"Change in MRI-detected subchondral bone marrow lesions is associated with cartilage loss: the MOST Study. A longitudinal multicentre study of knee osteoarthritis.","volume":"68","author":"Roemer","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2011.150243_bib3","doi-asserted-by":"crossref","first-page":"330","DOI":"10.7326\/0003-4819-139-5_Part_1-200309020-00008","article-title":"Bone marrow edema and its relation to progression of knee osteoarthritis.","volume":"139","author":"Felson","year":"2003","journal-title":"Ann Intern Med"},{"key":"10.1136\/ard.2011.150243_bib4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.joca.2003.11.003","article-title":"Whole-organ magnetic resonance imaging score (WORMS) of the knee in osteoarthritis.","volume":"12","author":"Peterfy","year":"2004","journal-title":"Osteoarthr Cartil"},{"key":"10.1136\/ard.2011.150243_bib5","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/rheumatology\/kei094","article-title":"The validation of simple scoring methods for evaluating compartment-specific synovitis detected by MRI in knee osteoarthritis.","volume":"44","author":"Rhodes","year":"2005","journal-title":"Rheumatology (Oxford)"},{"key":"10.1136\/ard.2011.150243_bib6","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.joca.2009.03.006","article-title":"Magnetic resonance imaging in osteoarthritis: which method best reflects synovial membrane inflammation? Correlations with clinical, macroscopic and microscopic features.","volume":"17","author":"Loeuille","year":"2009","journal-title":"Osteoarthr Cartil"},{"key":"10.1136\/ard.2011.150243_bib7","unstructured":"Aigner N, Van der Kraan P, Van den Berg W, Osteoarthritis and inflammation \u2013 inflammatory changes in osteoarthritis synoviopathy. In: Buckwalter J, Lotz M, Stoltz J-F, eds. Osteoarthritis, Inflammation and Degradation: A Continuum. Amsterdam, NL: IOS Press, 2007:219\u201335."},{"key":"10.1136\/ard.2011.150243_bib8","first-page":"1247","article-title":"Prevalence of cartilage shards in synovium and their association with synovitis in patients with early and endstage osteoarthritis.","volume":"19","author":"Myers","year":"1992","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2011.150243_bib9","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/art.1780310214","article-title":"Articular responses to purified cartilage proteoglycans.","volume":"31","author":"Boniface","year":"1988","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2011.150243_bib10","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00296-009-1032-2","article-title":"Investigation of calcium crystals in OA knees.","volume":"30","author":"Fuerst","year":"2010","journal-title":"Rheumatol Int"},{"key":"10.1136\/ard.2011.150243_bib11","first-page":"1330","article-title":"Knee effusions, popliteal cysts, and synovial thickening: association with knee pain in osteoarthritis.","volume":"28","author":"Hill","year":"2001","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2011.150243_bib12","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1136\/ard.2009.121426","article-title":"Relation of synovitis to knee pain using contrast-enhanced MRIs.","volume":"69","author":"Baker","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2011.150243_bib13","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1136\/ard.2006.067470","article-title":"Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis.","volume":"66","author":"Hill","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2011.150243_bib14","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1148\/radiol.2523082197","article-title":"Tibiofemoral joint osteoarthritis: risk factors for MR-depicted fast cartilage loss over a 30-month period in the multicenter osteoarthritis study.","volume":"252","author":"Roemer","year":"2009","journal-title":"Radiology"},{"key":"10.1136\/ard.2011.150243_bib15","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.joca.2005.01.005","article-title":"Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis \u2013 results of a 1 year longitudinal arthroscopic study in 422 patients.","volume":"13","author":"Ayral","year":"2005","journal-title":"Osteoarthr Cartil"},{"key":"10.1136\/ard.2011.150243_bib16","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1136\/ard.2004.025270","article-title":"Synovial tissue inflammation in early and late osteoarthritis.","volume":"64","author":"Benito","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2011.150243_bib17","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.joca.2008.09.013","article-title":"The association of meniscal damage with joint effusion in persons without radiographic osteoarthritis: the Framingham and MOST osteoarthritis studies.","volume":"17","author":"Roemer","year":"2009","journal-title":"Osteoarthr Cartil"},{"key":"10.1136\/ard.2011.150243_bib18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0730-725X(94)00119-N","article-title":"Synovial thickening detected by MR imaging in osteoarthritis of the knee confirmed by biopsy as synovitis.","volume":"13","author":"Fernandez-Madrid","year":"1995","journal-title":"Magn Reson Imaging"},{"key":"10.1136\/ard.2011.150243_bib19","first-page":"1662","article-title":"Synovial inflammation in patients with early osteoarthritis of the knee.","volume":"17","author":"Myers","year":"1990","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2011.150243_bib20","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1136\/ard.2006.066183","article-title":"The reliability of a new scoring system for knee osteoarthritis MRI and the validity of bone marrow lesion assessment: BLOKS (Boston Leeds Osteoarthritis Knee Score).","volume":"67","author":"Hunter","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2011.150243_bib21","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.joca.2010.07.008","article-title":"Anatomical distribution of synovitis in knee osteoarthritis and its association with joint effusion assessed on non-enhanced and contrast-enhanced MRI.","volume":"18","author":"Roemer","year":"2010","journal-title":"Osteoarthr Cartil"},{"key":"10.1136\/ard.2011.150243_bib22","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.2214\/AJR.08.2038","article-title":"Hoffa's fat pad: evaluation on unenhanced MR images as a measure of patellofemoral synovitis in osteoarthritis.","volume":"192","author":"Roemer","year":"2009","journal-title":"AJR Am J Roentgenol"},{"key":"10.1136\/ard.2011.150243_bib23","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/art.30148","article-title":"Reversible MRI features and knee pain fluctuation: the MOST study.","volume":"63","author":"Zhang","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2011.150243_bib24","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/1047-2797(94)00096-C","article-title":"A connective tissue disease screening questionnaire for population studies.","volume":"5","author":"Karlson","year":"1995","journal-title":"Ann Epidemiol"},{"key":"10.1136\/ard.2011.150243_bib25","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/ard.16.4.494","article-title":"Radiological assessment of osteo-arthrosis.","volume":"16","author":"Kellgren","year":"1957","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2011.150243_bib26","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s00256-002-0603-z","article-title":"Comparison of fixed-flexion positioning with fluoroscopic semi-flexed positioning for quantifying radiographic joint-space width in the knee: test\u2013retest reproducibility.","volume":"32","author":"Peterfy","year":"2003","journal-title":"Skeletal Radiol"},{"key":"10.1136\/ard.2011.150243_bib27","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/art.21724","article-title":"The association of meniscal pathologic changes with cartilage loss in symptomatic knee osteoarthritis.","volume":"54","author":"Hunter","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2011.150243_bib28","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1002\/art.22016","article-title":"Change in joint space width: hyaline articular cartilage loss or alteration in meniscus?","volume":"54","author":"Hunter","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2011.150243_bib29","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0950-3579(96)80047-1","article-title":"Synovial fluid cell analysis.","volume":"10","author":"Dougados","year":"1996","journal-title":"Baillieres Clin Rheumatol"},{"key":"10.1136\/ard.2011.150243_bib30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/00002281-199503000-00003","article-title":"Clinical assessment of osteoarthritis in clinical trials.","volume":"7","author":"Dougados","year":"1995","journal-title":"Curr Opin Rheumatol"},{"key":"10.1136\/ard.2011.150243_bib31","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1053\/joca.1998.0224","article-title":"T-cell mediated inflammatory pathway in osteoarthritis.","volume":"7","author":"Nakamura","year":"1999","journal-title":"Osteoarthr Cartil"},{"key":"10.1136\/ard.2011.150243_bib32","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1002\/art.21373","article-title":"Macroscopic and microscopic features of synovial membrane inflammation in the osteoarthritic knee: correlating magnetic resonance imaging findings with disease severity.","volume":"52","author":"Loeuille","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2011.150243_bib33","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1002\/art.1780381017","article-title":"The incidence and natural history of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study.","volume":"38","author":"Felson","year":"1995","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2011.150243_bib34","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/art.24337","article-title":"Is obesity a risk factor for progressive radiographic knee osteoarthritis?","volume":"61","author":"Niu","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2011.150243_bib35","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.joca.2009.08.017","article-title":"A comparison of dedicated 1.0 T extremity MRI vs large-bore 1.5 T MRI for semiquantitative whole organ assessment of osteoarthritis: the MOST study.","volume":"18","author":"Roemer","year":"2010","journal-title":"Osteoarthr Cartil"},{"key":"10.1136\/ard.2011.150243_bib36","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s00256-003-0635-z","article-title":"The value of water-excitation 3D FLASH and fat-saturated PDw TSE MR imaging for detecting and grading articular cartilage lesions of the knee.","volume":"32","author":"Mohr","year":"2003","journal-title":"Skeletal Radiol"},{"key":"10.1136\/ard.2011.150243_bib37","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00256-008-0491-y","article-title":"Prevalence of pathologic findings in asymptomatic knees of marathon runners before and after a competition in comparison with physically active subjects \u2013 a 3.0 T magnetic resonance imaging study.","volume":"37","author":"Stahl","year":"2008","journal-title":"Skeletal Radiol"},{"key":"10.1136\/ard.2011.150243_bib38","article-title":"Semiquantitative assessment of focal cartilage damage at 3T MRI: a comparative study of dual echo at steady state (DESS) and intermediate-weighted (IW) fat suppressed fast spin echo sequences.","author":"Roemer","year":"2010","journal-title":"Eur J Radiol"},{"key":"10.1136\/ard.2011.150243_bib39","first-page":"2306","article-title":"Detecting radiological changes in rheumatoid arthritis that are considered important by clinical experts: influence of reading with or without known sequence.","volume":"29","author":"Bruynesteyn","year":"2002","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2011.150243_bib40","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1002\/jbmr.5650111124","article-title":"Blinded reading of radiographs increases the frequency of errors in vertebral fracture detection.","volume":"11","author":"Ross","year":"1996","journal-title":"J Bone Miner Res"},{"key":"10.1136\/ard.2011.150243_bib41","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.joca.2008.09.008","article-title":"Blinding images to sequence in osteoarthritis: evidence from other diseases.","volume":"17","author":"Felson","year":"2009","journal-title":"Osteoarthr Cartil"},{"issue":"Suppl","key":"10.1136\/ard.2011.150243_bib42","first-page":"S128","article-title":"MRI prevalence of different features of knee osteoarthritis in persons with normal knee x-rays.","volume":"56","author":"Guermazi","year":"2007","journal-title":"Arhritis Rheum"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724191315?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724191315?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.2011.150243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T08:56:40Z","timestamp":1736067400000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724191315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0003496724191315"],"URL":"https:\/\/doi.org\/10.1136\/ard.2011.150243","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.2011.150243","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Published by Elsevier Inc. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}