{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T23:52:08Z","timestamp":1769557928740,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1973,11,1]],"date-time":"1973-11-01T00:00:00Z","timestamp":120960000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1973,11,1]],"date-time":"1973-11-01T00:00:00Z","timestamp":120960000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[1973,11]]},"DOI":"10.1136\/ard.32.6.536","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T23:49:46Z","timestamp":1217288986000},"page":"536-546","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"title":["Methotrexate therapy in polymyositis."],"prefix":"10.1016","volume":"32","author":[{"given":"F.C","family":"Arnett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.C","family":"Whelton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.M","family":"Zizic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.B","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"ref_1","first-page":"931","article-title":"(Folic acid antagonists: effects on the cell and the patient)","volume":"59","author":"BERLIN, N.I.; RALL, D.; MEAD, J.A.R.; FREIRECH, E.J.; ScoTT, V.A.N.; E., H.E.R.T.Z.; R.; LIPsETr, M.B.","year":"1963","unstructured":"BERLIN, N. I., RALL, D., MEAD, J. A. R., FREIRECH, E. J., VAN ScoTT, E., HERTZ, R., AND LIPsETr, M. B. (1963) Ann. intern. Med., 59, 931 (Folic acid antagonists: effects on the cell and the patient)","journal-title":"Ann. intern. Med"},{"key":"ref_2","first-page":"227","article-title":"Arch","volume":"30","author":"BROCK, W.G.","year":"1934","unstructured":"BROCK, W. G. (1934) Arch. Derm. Syph. (Chicago), 30, 227 (Dermatomyositis and diffuse scleroderma, differential diagnosis and reports of cases)","journal-title":"Derm. Syph. (Chicago); Dermatomyositis and diffuse scleroderma, differential diagnosis and reports of cases"},{"issue":"1","key":"ref_3","article-title":"Ann. rheum","volume":"20","author":"BuNIM, J.J.","year":"1961","unstructured":"BuNIM, J. J. (1961) Ann. rheum. Dis., 20, 1 (A broader spectrum of Sjogren's syndrome and its pathogenetic implications)","journal-title":"Dis; A broader spectrum of Sjogren's syndrome and its pathogenetic implications"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1001\/jama.1969.03160250017003","article-title":"(Pulmonary disease complicating intermittent therapy","volume":"209","author":"CLARYSSE, A.M.; CATHEY, W.J.; CARTWRIGHT, G.E.; WINTROBE, M.M.","year":"1969","unstructured":"CLARYSSE, A. M., CATHEY, W. J., CARTWRIGHT, G. E., AND WINTROBE, M. M. (1969) J. Amer. med. Ass., 209, 1861 (Pulmonary disease complicating intermittent therapy with methotrexate)","journal-title":"J. Amer. med. Ass"},{"key":"ref_5","first-page":"923","article-title":"COOPERATIVE STUDY: AcuTE LEUKEMIA","volume":"207","year":"1969","unstructured":"COOPERATIVE STUDY: AcuTE LEUKEMIA GROUP B (1969) Ibid., 207, 923 (Acute lymphocytic leukemia in children. Maintenance therapy with Methotrexate administered intermittently)","journal-title":"Acute lymphocytic leukemia in children. Maintenance therapy with Methotrexate administered intermittently; Ibid"},{"key":"ref_6","first-page":"11","article-title":"Acta neuropathol","volume":"15","author":"CURRIE, S.","year":"1970","unstructured":"CURRIE, S. (1970) Acta neuropathol. (Ber.), 15, 11 (Destruction of muscle cultures by lymphocytes from cases of polymyositis)","journal-title":"(Ber.); Destruction of muscle cultures by lymphocytes from cases of polymyositis"},{"key":"ref_7","article-title":"63 (Immunological aspects of polymyositis: the in vitro activity of lymphocytes on incubation with muscle antigen and with muscle cultures)","volume":"40","author":"SAUNDERS, M.; KNOwLES, M.; BROWN, A.E.","year":"1971","unstructured":", SAUNDERS, M., KNOwLES, M., AND BROWN, A. E. (1971) Quart. J. Med., 40, 63 (Immunological aspects of polymyositis: the in vitro activity of lymphocytes on incubation with muscle antigen and with muscle cultures)","journal-title":"Quart. J. Med"},{"key":"ref_8","first-page":"159","article-title":"The clinical picture of systemic lupus erythematosus', in \"Lupus Erythematosus","author":"DUBoIs, E.L.","year":"1966","unstructured":"DUBoIs, E. L. (1966) 'The clinical picture of systemic lupus erythematosus', in \"Lupus Erythematosus\", ed. E. L. Dubois, pp. 159-162. McGraw-Hill, New York"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1001\/jama.1971.03180310117023","article-title":"(Pulmonary and hepatic complications of Methotrexate therapy of psoriasis)","volume":"216","author":"FILIP, D.J.; LOoGuE, G.L.; HARLE, T.S.; FARRAR, W.H.","year":"1971","unstructured":"FILIP, D. J., LOoGuE, G. L., HARLE, T. S., AND FARRAR, W. H. (1971) J. Amer. med. Ass., 216, 881 (Pulmonary and hepatic complications of Methotrexate therapy of psoriasis)","journal-title":"J. Amer. med. Ass"},{"key":"ref_10","article-title":"Arch","volume":"103","author":"GOLDMAN, G.C.; MOSCHELLA, S.L.","year":"1971","unstructured":"GOLDMAN, G. C., AND MOSCHELLA, S. L. (1971) Arch. Derm., 103, 194 (Severe pneumonitis occurring during Methotrexate therapy)","journal-title":"Derm; Severe pneumonitis occurring during Methotrexate therapy"},{"key":"ref_11","article-title":"Blood, 27, 38 (Inhibition of the local inflammatory response in man by antimetabolites)","author":"HERSH, E.M.; WONG, V.G.; FREIREIC, E.J.","year":"1966","unstructured":"HERSH, E. M., WONG, V. G., AND FREIREIC, E. J. (1966) Blood, 27, 38 (Inhibition of the local inflammatory response in man by antimetabolites)"},{"key":"ref_12","article-title":"Lancet, 2,485 (Treatment","author":"MALAV1YA, A.N.; MANY, A.; SCHWARTZ, R.S.","year":"1968","unstructured":"MALAV1YA, A. N., MANY, A., AND SCHWARTZ, R. S. (1968) Lancet, 2,485 (Treatment of dermatomyositis with methotrexate)"},{"issue":"4","key":"ref_13","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/art.1780110405","article-title":"(Skeletal muscle involvement in progressive systemic sclerosis","volume":"11","author":"MEDSGER, T.A.; RODNAN, G.P.; MOOSSY, J.; VESTER, J.W.","year":"1968","unstructured":"MEDSGER, T. A., RODNAN, G. P., MOOSSY, J., AND VESTER, J. W. (1968) Arthr. and Rheum., 11, No. 4 (August), p. 554 (Skeletal muscle involvement in progressive systemic sclerosis (scleroderma))","journal-title":"Arthr. and Rheum"},{"key":"ref_14","first-page":"535","article-title":"Ann","volume":"70","author":"MITCHELL, M.S.; WADE, M.E.; DECONTI, R.C.; BERTINO, J.R.; CALABRESI, P.","year":"1969","unstructured":"MITCHELL, M. S., WADE, M. E., DECONTI, R. C., BERTINO, J. R., AND CALABRESI, P. (1969) Ann. intern. Med., 70, 535 (Immunosuppressive effects of cytosine arabinoside and Methotrexate in man)","journal-title":"intern. Med; Immunosuppressive effects of cytosine arabinoside and Methotrexate in man"},{"issue":"2017","key":"ref_15","article-title":"(Daunorubicin treatment of Methotrexate pneumonia)","volume":"216","author":"PAsQusuccI, G.; FERRARA, P.; CASTELLARI, R.","year":"1971","unstructured":"PAsQusuccI, G., FERRARA, P., AND CASTELLARI, R. (1971) J. Amer. med. Ass., 216,2017 (Daunorubicin treatment of Methotrexate pneumonia)","journal-title":"J. Amer. med. Ass"},{"key":"ref_16","first-page":"269","article-title":"(Polymyositis and dermatomyositis) -","volume":"12","author":"PEARSON, C.M.","year":"1962","unstructured":"PEARSON, C. M. (1962) Bull. rheum. Dis., 12, 269 (Polymyositis and dermatomyositis) - (1966) Ann. Rev. Med., 17, 63 (Polymyositis)","journal-title":"Bull. rheum. Dis"},{"key":"ref_17","first-page":"511","article-title":"Polymyositis and related disorders', in \"Disorders of Voluntary Muscle","author":"PEARSON, C.M.","year":"1969","unstructured":"PEARSON, C. M. (1969) 'Polymyositis and related disorders', in \"Disorders of Voluntary Muscle\", ed. J. N. Walton, 2nd ed., pp. 511-512.","edition":"2nd ed"},{"key":"ref_18","article-title":"Transplantation, 5, 1223 (Methotrexate and the immune response)","author":"Churchill, London R.I.V.A.R.O.L.A.; A., F.R.I.E.D.M.A.N.; M.; LAWRENCE, JR, W.","year":"1967","unstructured":"Churchill, London RIVAROLA, A., FRIEDMAN, M., AND LAWRENCE, W., JR. (1967) Transplantation, 5, 1223 (Methotrexate and the immune response)"},{"key":"ref_19","first-page":"156","article-title":"Brit","volume":"2","author":"ROBFRTSON, J.H.","year":"1970","unstructured":"ROBFRTSON, J. H. (1970) Brit. med. J., 2, 156 (Pneumonia and methotrexate)","journal-title":"med. J"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1136\/jnnp.32.6.569","article-title":"(Lymphocyte stimulation with muscle homogenate in polymyositis and other muscle-wasting disorders)","volume":"32","author":"SAUNDERS, M.; KNOWLES, M.; CURRIE, S.","year":"1969","unstructured":"SAUNDERS, M., KNOWLES, M., AND CURRIE, S. (1969) J. Neurol. Neurosurg. Psychiat., 32, 569 (Lymphocyte stimulation with muscle homogenate in polymyositis and other muscle-wasting disorders)","journal-title":"J. Neurol. Neurosurg. Psychiat"},{"key":"ref_21","first-page":"713","article-title":"Dermatomyositis (polymyositis)' in \"Textbook of Immunopathology","volume-title":"Treatment of corticosteroid-resistant polymyositis","volume":"2","author":"SHULMAN, L.E.","year":"1969","unstructured":"SHULMAN, L. E. (1969) 'Dermatomyositis (polymyositis)' in \"Textbook of Immunopathology\", vol. 2, ed. P. A. Miescher and H. J. Muller-Eberhard, pp. 713-716. Grune and Stratton, New York SOKOLOFF, M. C., GOLDBERG, L. S., AND PEARSON, C. M. (1971) Lancet, 1, 14 (Treatment of corticosteroid-resistant polymyositis with methotrexate)"},{"key":"ref_22","first-page":"281","article-title":"1924 (Methotrexate therapy and pulmonary disease)","volume":"210","author":"SCHWARTZ, I.R.; KAJANI, M.K.","year":"1969","unstructured":"SCHWARTZ, I. R., AND KAJANI, M. K. (1969) J. Amer. med. Ass., 210, 1924 (Methotrexate therapy and pulmonary disease) THOMPSON, J. M., BLUE5TONE, R., BYWATERS, E. G. L., DORLING, J., AND JOHNSON, M. (1969) Ann. rheum. Dis., 28, 281 (Skeletal muscle involvement in systemic sclerosis)","journal-title":"J. Amer. med. Ass"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1001\/archinte.1964.03860080113012","volume":"114","author":"VIGNOS, JR., P.J.; BOWLING, G.F.; WATKINS, M.P.","year":"1964","unstructured":"VIGNOS, P. J., JR., BOWLING, G. F., AND WATKINS, M. P. (1964) Arch. intern. Med., 114, 263 (Polymyositis, effect of corticosteroids on final result)","journal-title":"Arch. intern. Med"},{"key":"ref_24","first-page":"333","article-title":"New Engl","volume":"286","author":"WHITAKER, J.N.; ENGEL, W.K.","year":"1972","unstructured":"WHITAKER, J. N., AND ENGEL, W. K. (1972) New Engl. J. Med., 286, 333 (Vascular deposits of immunoglobulin and complement in idiopathic inflammatory myopathy) WmTE, W. (1959) Proc. roy. Soc. Med., 52, 1035 (Lupus erythematosus. Polymyositis)","journal-title":"J. Med; Vascular deposits of immunoglobulin and complement in idiopathic inflammatory myopathy) WmTE, W"},{"key":"ref_25","first-page":"1174","article-title":"Ann","volume":"50","author":"WILLIAMS, JR, R.C.","year":"1959","unstructured":"WILLIAMS, R. C., JR. (1959) Ann. intern. Med., 50, 1174 (Dermatomyositis and malignancy: a review of the literature)","journal-title":"intern. Med; Dermatomyositis and malignancy: a review of the literature"},{"key":"ref_26","first-page":"545","article-title":"Mayo Clin","volume":"43","author":"WINKELMANN, R.K.; MULDER, D.W.; LAMBERT, E.H.; HOWARD, JR., F.M.; DIESSNER, G.R.","year":"1968","unstructured":"WINKELMANN, R. K., MULDER, D. W., LAMBERT, E. H., HOWARD, F. M., JR., AND DIESSNER, G. R. (1968) Mayo Clin. Proc., 43, 545 (Course of dermatomyositis-polymyositis: comparison of untreated and cortisone-treated patients)","journal-title":"Proc"},{"key":"ref_27","first-page":"331","article-title":"Surg","volume":"126","author":"ZUREK, W.Z.; OJIMA, Y.; ANDERSON, L.L.; COLLINS, G.J.; OBERFIELD, R.A.; SULLIVAN, R.D.","year":"1968","unstructured":"ZUREK, W. Z., OJIMA, Y., ANDERSON, L. L., COLLINS, G. J., OBERFIELD, R. A., AND SULLIVAN, R. D. (1968) Surg. Gynec. Obstet., 126, 331 (Pharmacologic studies of methotrexate in man)","journal-title":"Gynec. Obstet; Pharmacologic studies of methotrexate in man"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000349672441279X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000349672441279X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.32.6.536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T12:06:18Z","timestamp":1737547578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000349672441279X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,11]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1973,11]]}},"alternative-id":["S000349672441279X"],"URL":"https:\/\/doi.org\/10.1136\/ard.32.6.536","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[1973,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methotrexate therapy in polymyositis.","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.32.6.536","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1973 \u00a9 THE AUTHORS. Published by Elsevier B.V. on behalf of European Alliance of Associations for Rheumatology, EULAR. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}