{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T09:36:18Z","timestamp":1771493778516,"version":"3.50.1"},"reference-count":15,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1973,11,1]],"date-time":"1973-11-01T00:00:00Z","timestamp":120960000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1973,11,1]],"date-time":"1973-11-01T00:00:00Z","timestamp":120960000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[1973,11]]},"DOI":"10.1136\/ard.32.6.589","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T23:49:46Z","timestamp":1217288986000},"page":"589-591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Proceedings: Controlled trial of azathioprine in rheumatoid vasculitis."],"prefix":"10.1016","volume":"32","author":[{"given":"A","family":"Nicholls","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.L","family":"Snaith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.N","family":"Maini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.T","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"ref_1","first-page":"1154","volume":"2","author":"Exton-Smith, A.N.; Milland, P.H.; Payne, P.R.; Wheeler, E.F.","year":"1969","unstructured":"Exton-Smith, A. N., Milland, P. H., Payne, P. R., and Wheeler, E. F. (1969) Lancet, 2, 1154"},{"key":"ref_2","first-page":"259","article-title":"Ann","volume":"31","author":"Foss, M.V.L.; Byers, P.D.","year":"1972","unstructured":"Foss, M. V. L., and Byers, P. D. (1972) Ann. rheum. Dis., 31, 259","journal-title":"rheum. Dis"},{"issue":"0","key":"ref_3","first-page":"2","volume":"3","author":"mg\/kg","year":"1972","unstructured":"2 5 mg.\/kg. 1972 3 0 mg.\/kg. 1971 2-3 5 mg.\/kg."},{"key":"ref_4","article-title":"Up to 150 mg. (Control up to 15 mg.)","unstructured":"Up to 150 mg. (Control up to 15 mg.)"},{"key":"ref_5","article-title":"Up to 150 mg","author":"mg\/kg","year":"1972","unstructured":"0 7-1 mg.\/kg. 1972 Up to 150 mg."},{"key":"ref_6","first-page":"mg.","article-title":"Control up to 75 mg.)","volume":"117","year":"1972","unstructured":"(Control up to 75 mg.) 1972 117 mg."},{"key":"ref_7","article-title":"JASANI (Horsham) Perhaps I can throw some light on the problem outlined by Dr. Holt and the counter argument put by Dr. Maini. It is true to say that cytotoxic agents do in fact have an immunological effect quite separate from any anti-inflammatory effect; and it may therefore be quite possible to observe a substantial anti-inflammatory effect, e.g. improvement in joint pain, without having to alter the underlying immunological disorder (Swanson and Schwartz, 1967). But in relation to the present study, the important point is to know of some objective measurement that could enable us to judge whether the amount of drug employed was sufficient to induce the desired therapeutic effect, i.e. the arrest of recurrent vasculitis. In my view serially-obtained platelet counts might be one such criterion","author":"K, M.","unstructured":"DR. M. K. JASANI (Horsham) Perhaps I can throw some light on the problem outlined by Dr. Holt and the counter argument put by Dr. Maini. It is true to say that cytotoxic agents do in fact have an immunological effect quite separate from any anti-inflammatory effect; and it may therefore be quite possible to observe a substantial anti-inflammatory effect, e.g. improvement in joint pain, without having to alter the underlying immunological disorder (Swanson and Schwartz, 1967). But in relation to the present study, the important point is to know of some objective measurement that could enable us to judge whether the amount of drug employed was sufficient to induce the desired therapeutic effect, i.e. the arrest of recurrent vasculitis. In my view serially-obtained platelet counts might be one such criterion."},{"issue":"883","key":"ref_8","first-page":"434","article-title":"New Engl","volume":"283","author":"Arthr. and Rheum.,","year":"1970","unstructured":"Co-operating Clinics Committee of the American Rheumatism Association (1970) New Engl. J. Med., 283, 883 (1972) Arthr. and Rheum., 15, 434","journal-title":"J. Med"},{"key":"ref_9","first-page":"116","volume":"15","author":"Levy, J.; Paulus, H.E.; Barnett, E.V.; Sokoloff, M.; Bangert, R.; Pearson, C.M.","year":"1972","unstructured":"Levy, J., Paulus, H. E., Barnett, E. V., Sokoloff, M., Bangert, R., and Pearson, C. M. (1972) Ibid., 15, 116","journal-title":"Ibid"},{"key":"ref_10","first-page":"117","volume":"15","author":"Lidsky, M.D.; Sharp, J.T.; Billings, S.; Curtis, J.E.; Hersh, E.M.","year":"1972","unstructured":"Lidsky, M. D., Sharp, J. T., Billings, S., Curtis, J. E., and Hersh, E. M. (1972) Ibid., 15, 117","journal-title":"Ibid"},{"key":"ref_11","first-page":"421","volume":"1","author":"Mason, M.; Currey, H.L.F.; Barnes, C.G.; Dunne, J.F.; Hazleman, B.L.; Strickland, I.D.","year":"1969","unstructured":"Mason, M., Currey, H. L. F., Barnes, C. G., Dunne, J. F., Hazleman, B. L., and Strickland, I. D. (1969) Brit. med. J., 1, 421","journal-title":"Brit. med. J"},{"key":"ref_12","first-page":"163","article-title":"New Engl","volume":"277","author":"Swanson, M.A.; Schwartz, R.S.","year":"1967","unstructured":"Swanson, M. A., and Schwartz, R. S. (1967) New Engl. J. Med., 277, 163","journal-title":"J. Med"},{"key":"ref_13","article-title":"Arthr","author":"Townes, A.S.; Sowa, J.M.; Shulman, L.E.","year":"1972","unstructured":"Townes, A. S., Sowa, J. M., and Shulman, L. E. (1972) Arthr. and"},{"key":"ref_14","first-page":"419","volume":"14","author":"Urowitz, M.B.; Gordon, D.A.; Smythe, H.A.; Pruzanski, W.; Ogryzlo, M.A.","year":"1971","unstructured":"Urowitz, M. B., Gordon, D. A., Smythe, H. A., Pruzanski, W., and Ogryzlo, M. A. (1971) Ibid., 14, 419","journal-title":"Ibid"},{"key":"ref_15","article-title":"The pathogenesis of cutaneous vasculitis is unknown but recent investigations have suggested that immunological phenomena, such as the precipitation of immune complexes, may be important. As a result of the immunological reaction occurring within the blood vessel wall this may culminate in the formation of a thrombus. Investigation of blood coagulation factors are limited, but studies of fibrinolysis have been more detailed. We have demonstrated that 60 per cent. of patients with cutaneous vasculitis have an impaired fibrinolytic activity and Parish","volume-title":"has confirmed this observation","year":"1972","unstructured":"[This paper and the discussion thereon will be published in full in the Annals in January (1974).]"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724412910?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724412910?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.32.6.589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T12:06:44Z","timestamp":1737547604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724412910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,11]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1973,11]]}},"alternative-id":["S0003496724412910"],"URL":"https:\/\/doi.org\/10.1136\/ard.32.6.589","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[1973,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proceedings: Controlled trial of azathioprine in rheumatoid vasculitis.","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.32.6.589","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1973 \u00a9 THE AUTHORS. 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