{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T23:36:43Z","timestamp":1761953803053,"version":"build-2065373602"},"reference-count":26,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1982,12,1]],"date-time":"1982-12-01T00:00:00Z","timestamp":407548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1982,12,1]],"date-time":"1982-12-01T00:00:00Z","timestamp":407548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[1982,12]]},"DOI":"10.1136\/ard.41.6.563","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T23:49:46Z","timestamp":1217288986000},"page":"563-568","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of sera from patients with rheumatoid arthritis on normal lymphocytes: a possible immunoregulatory role for immune complexes."],"prefix":"10.1016","volume":"41","author":[{"given":"J","family":"Highton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.S","family":"Panayi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Shepherd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Wooley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"ref_1","first-page":"3","article-title":"Lymphocyte function in rheumatoid arthritis","volume-title":"Immunopathogenesis of Rheumatoid Arthritis","author":"S, Panayi G.; V, Corrigall","year":"1978","unstructured":"Panayi G S, Corrigall V. Lymphocyte function in rheumatoid arthritis. In: Panayi G S, Johnson P M, eds. Immunopathogenesis of Rheumatoid Arthritis. Chertsey, Surrey: Reed Books, 1978: 3-6."},{"key":"ref_2","first-page":"129","article-title":"Early joint lesions of rheumatoid arthritis","volume":"59","author":"P, Kulka J.; D, Bocking; W, Ropes M.; W, Bauer","year":"1955","unstructured":"Kulka J P, Bocking D, Ropes M W, Bauer W. Early joint lesions of rheumatoid arthritis. Arch Pathol 1955; 59: 129-50.","journal-title":"Arch Pathol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/art.1780150502","article-title":"Synovitis of recent onset. A clinicopathologic study during","volume":"15","author":"R, Schumacher H.; C, Kitridou R.","year":"1972","unstructured":"Schumacher H R, Kitridou R C. Synovitis of recent onset. A clinicopathologic study during the first month of disease. Arthritis Rheum 1972; 15: 465-85.","journal-title":"Arthritis Rheum"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1749-6632.1975.tb36034.x","article-title":"Synovial membrane and fluid morphologic alterations in early rheumatoid arthritis: microscopic vascular injury and virus-like particles","volume":"256","author":"R, Schumacher H.","year":"1975","unstructured":"Schumacher H R. Synovial membrane and fluid morphologic alterations in early rheumatoid arthritis: microscopic vascular injury and virus-like particles. Ann N Y Acad Sci 1975; 256: 39-64.","journal-title":"Ann N Y Acad Sci"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/1529-0131(197607\/08)19:4<743::AID-ART1780190414>3.0.CO;2-L","article-title":"Mononuclear cells in human synovial fluid: identification of lymphoblasts in rheumatoid arthritis","volume":"19","author":"B, Traycoff R.; E, Pascual; R, Schumacher H.","year":"1976","unstructured":"Traycoff R B, Pascual E, Schumacher H R. Mononuclear cells in human synovial fluid: identification of lymphoblasts in rheumatoid arthritis. Arthritis Rheum 1976; 19: 743-8.","journal-title":"Arthritis Rheum"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1749-6632.1975.tb36044.x","article-title":"The role of the lymphocyte and its products in the propagation of joint disease","volume":"256","author":"M, Pearson C.; E, Paulus H.; I, Machleder H.","year":"1975","unstructured":"Pearson C M, Paulus H E, Machleder H I. The role of the lymphocyte and its products in the propagation of joint disease. Ann N Y Acad Sci 1975; 256: 150-68.","journal-title":"Ann N Y Acad Sci"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3109\/03009747609099900","article-title":"Extracorporeal irradiation of thoracic duct lymph as immunosuppressive treatment in rheumatoid arthritis","volume":"6","author":"Edgren, J.; Klockars, M.; Weber, T.","year":"1976","unstructured":"Edgren J, Klockars M, Weber T, et al. Extracorporeal irradiation of thoracic duct lymph as immunosuppressive treatment in rheumatoid arthritis. Scand J Rheumatol 1976; 6: 108-12.","journal-title":"Scand J Rheumatol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1136\/ard.40.3.254","article-title":"Changes in immune function in patients with rheumatoid arthritis following treatment with sodium aurothiomalate","volume":"40","author":"Highton, J.; S, Panayi G.; Shepherd, P.; Griffin, J.; Gibson, T.","year":"1981","unstructured":"Highton J, Panayi G S, Shepherd P, Griffin J, Gibson T. Changes in immune function in patients with rheumatoid arthritis following treatment with sodium aurothiomalate.Ann Rheum Dis 1981; 40: 254-62.","journal-title":"Ann Rheum Dis"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0019-2791(65)90004-2","article-title":"Immunochemical quantitation of antigens by single radial immunodiffusion","volume":"2","year":"1965","unstructured":"Mancini G, Carbonara A 0, Heremans J F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry 1965; 2: 235-54.","journal-title":"Immunochemistry"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1042\/bj1300749","article-title":"Isolation and characterisation of Clq, a subcomponent of the first component of complement, from human and rabbit sera","volume":"130","author":"M, Reid K.B.; M, Lowe D.; R, Porter R.","year":"1972","unstructured":"Reid K B M, Lowe D M, Porter R R. Isolation and characterisation of Clq, a subcomponent of the first component of complement, from human and rabbit sera. Biochem J 1972; 130: 749-63.","journal-title":"Biochem J"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000229699","article-title":"A method of trace iodination of proteins for immunologic studies","volume":"29","author":"J, McConahey P.; J, Dixon F.","year":"1966","unstructured":"McConahey P J, Dixon F J. A method of trace iodination of proteins for immunologic studies. Int Arch Allergy Appl Immunol 1966; 29: 185-9.","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"232","DOI":"10.4049\/jimmunol.116.1.232","article-title":"Detection of immune complexes in unheated sera by a modified \"25I-labelled Clq binding test","volume":"116","author":"H, Zubler R.; G, Lange; H, Lambert P.; A, Miescher P.","year":"1976","unstructured":"Zubler R H, Lange G, Lambert P H, Miescher P A. Detection of immune complexes in unheated sera by a modified \"25I-labelled Clq binding test. J Immunol 1976; 116: 232-5.","journal-title":"J Immunol"},{"key":"ref_13","first-page":"77","article-title":"Isolation of mononuclear cells and granulocytes from human blood. ScandJ Clin Lab Invest","volume":"97","author":"Boyum, A.","year":"1968","unstructured":"Boyum A. Isolation of mononuclear cells and granulocytes from human blood. ScandJ Clin Lab Invest 1968; 21 (suppl 97): 77-89."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/204998b0","article-title":"Microdroplet assay of human serum cytotoxins","volume":"204","author":"I, Terasaki P.; D, McClelland J.","year":"1964","unstructured":"Terasaki P I, McClelland J D. Microdroplet assay of human serum cytotoxins. Nature 1964; 204: 998-1000.","journal-title":"Nature"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1097\/00007890-196811000-00006","article-title":"Serotyping for homotransplantation. XVIII. Refinement of microdroplet lymphocyte cytotoxicity test","volume":"6","author":"K, Mittal K.; R, Mickey M.; P, Singal D.; I, Terasaki P.","year":"1968","unstructured":"Mittal K K, Mickey M R, Singal D P, Terasaki P I. Serotyping for homotransplantation. XVIII. Refinement of microdroplet lymphocyte cytotoxicity test. Transplantation 1968; 6: 913-27.","journal-title":"Transplantation"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1136\/ard.40.2.154","article-title":"Lymphocytotoxins in rheumatoid arthritis: prevalence, lymphocyte specificity and HLA DR antigens","volume":"40","author":"H, Wooley P.; S, Panayi G.; R, Batchelor J.","year":"1981","unstructured":"Wooley P H, Panayi G S, Batchelor J R. Lymphocytotoxins in rheumatoid arthritis: prevalence, lymphocyte specificity and HLA DR antigens. Ann Rheum Dis 1981; 40: 154-6.","journal-title":"Ann Rheum Dis"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.4049\/jimmunol.123.3.1382","article-title":"Demonstration of circulating immune complexes in Sjogren'ssyndrome","volume":"123","author":"J, Lawley T.; M, Moutsopoulos H.; I, Katz S.; N, Theofilopoulos A.; M, Chused T.; M, Frank M.","year":"1979","unstructured":"Lawley T J, Moutsopoulos H M, Katz S I, Theofilopoulos A N, Chused T M, Frank M M. Demonstration of circulating immune complexes in Sjogren'ssyndrome.J Immunol 1979; 123: 1382-7.","journal-title":"J Immunol"},{"key":"ref_18","first-page":"822","article-title":"Pseudoimmune reaction with human y-globulin","volume":"97","author":"Forsgren, A.; from S. aureus. I, Sjoquist J.Protein A.","year":"1966","unstructured":"Forsgren A, Sjoquist J. Protein A from S. aureus. I. Pseudoimmune reaction with human y-globulin. J Immunol 1966; 97: 822-7.","journal-title":"J Immunol"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1172\/JCI109345","article-title":"Binding of immunoglobulin G aggregates and immune complexes in human serum to staphylococci containing protein A","volume":"63","author":"S, McDougal J.; B, Redecha P.; D, Inman R.; L, Christian C.","year":"1979","unstructured":"McDougal J S, Redecha P B, Inman R D, Christian C L. Binding of immunoglobulin G aggregates and immune complexes in human serum to staphylococci containing protein A. J Clin Invest 1979; 63: 627-36.","journal-title":"J Clin Invest"},{"key":"ref_20","first-page":"351","article-title":"Generation of suppressor cells by aggregated human globulin. Clin Exp Immunol","volume":"43","author":"P, Antel J.; E, Medof M.; J-F, Oger J.; H-H, Kuo; W, Arnason B.G.","year":"1981","unstructured":"Antel J P, Medof M E, Oger J J-F, Kuo H-H, Arnason B G W. Generation of suppressor cells by aggregated human globulin. Clin Exp Immunol 1981; 43: 351-6."},{"key":"ref_21","first-page":"252","article-title":"Antigenantibody complexes in disease. VIII. Fractionation of rheumatoid samples containing immune complex-like material","volume":"5","author":"Yue, R.; Tackaberry, E.; McAvoy, D.; Shustik, C.; Broder, I.","year":"1978","unstructured":"Yue R, Tackaberry E, McAvoy D, Shustik C, Broder I. Antigenantibody complexes in disease. VIII. Fractionation of rheumatoid samples containing immune complex-like material. J Rheumatol 1978; 5: 252-62.","journal-title":"J Rheumatol"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1056\/NEJM197010012831403","article-title":"Cytotoxins in disease. Autocytotoxins in lupus","volume":"283","author":"I, Terasaki P.; D, Mottironi V.; V, Barnett E.","year":"1970","unstructured":"Terasaki P I, Mottironi V D, Barnett E V. Cytotoxins in disease. Autocytotoxins in lupus. N Engl J Med 1970; 283: 724-8.","journal-title":"N Engl J Med"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0022-1759(80)90067-8","article-title":"The use of concanavalin A to measure acute phase proteins by laser nephelometry","volume":"32","author":"Warren, C.; Whicher, J.; Kohn, J.","year":"1980","unstructured":"Warren C, Whicher J, Kohn J. The use of concanavalin A to measure acute phase proteins by laser nephelometry. J Immunol Methods 1980; 32: 141-50.","journal-title":"J Immunol Methods"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1136\/ard.35.3.240","article-title":"Detection of IgG rheumatoid factor by concanavalin A treatment and complement fixation with IgG rheumatoid factor","volume":"35","author":"Tanimoto, K.; Moritoh, T.; Azuma, T.; Horiuchi, Y.","year":"1976","unstructured":"Tanimoto K, Moritoh T, Azuma T, Horiuchi Y. Detection of IgG rheumatoid factor by concanavalin A treatment and complement fixation with IgG rheumatoid factor. Ann Rheum Dis 1976; 35: 240-5.","journal-title":"Ann Rheum Dis"},{"key":"ref_25","first-page":"265","article-title":"Pathogenesis of rheumatoid arthritis","volume":"2","author":"S, Panayi G.","year":"1979","unstructured":"Panayi G S. Pathogenesis of rheumatoid arthritis. Eur J Rheumatol Inflamm 1979; 2: 265-71.","journal-title":"Eur J Rheumatol Inflamm"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1136\/ard.40.6.575","article-title":"Fall in immune complex levels during gold treatment of rheumatoid arthritis","volume":"40","author":"Highton, J.; S, Panayi G.; Shepherd, P.; Faith, A.; Griffin, J.; Gibson, T.","year":"1981","unstructured":"Highton J, Panayi G S, Shepherd P, Faith A, Griffin J, Gibson T. Fall in immune complex levels during gold treatment of rheumatoid arthritis. Ann Rheum Dis 1981; 40: 575-9.","journal-title":"Ann Rheum Dis"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724136369?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724136369?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.41.6.563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T06:21:55Z","timestamp":1737526915000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724136369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,12]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1982,12]]}},"alternative-id":["S0003496724136369"],"URL":"https:\/\/doi.org\/10.1136\/ard.41.6.563","relation":{},"ISSN":["0003-4967"],"issn-type":[{"type":"print","value":"0003-4967"}],"subject":[],"published":{"date-parts":[[1982,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of sera from patients with rheumatoid arthritis on normal lymphocytes: a possible immunoregulatory role for immune complexes.","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.41.6.563","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1982 \u00a9 THE AUTHORS. Published by Elsevier B.V. on behalf of European Alliance of Associations for Rheumatology, EULAR. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}