{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:06:53Z","timestamp":1759342013911,"version":"3.33.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[1989,9,1]],"date-time":"1989-09-01T00:00:00Z","timestamp":620611200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1989,9,1]],"date-time":"1989-09-01T00:00:00Z","timestamp":620611200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[1989,9]]},"DOI":"10.1136\/ard.48.9.771","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T23:49:46Z","timestamp":1217288986000},"page":"771-775","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Anticentromere antibody in patients without CREST and scleroderma: association with active digital vasculitis, rheumatic and connective tissue disease."],"prefix":"10.1016","volume":"48","author":[{"given":"J.A","family":"Goldman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"ref_1","unstructured":"Positive serum samples were tested for antibodies to double stranded DNA by the Farr technique, Sm, RNP, SSA, and SSB.12 C3 and C4 were measured by nephelometry (Smith Kline Bio-Science Laboratories, Atlanta, Georgia). Circulating immune complexes were measured by '25I Clq binding and staphylococci binding assays carried out at the Center for Disease Control.'y'5 The normal range for Clq binding assay is less than 8% and for the staphylococci binding assay less than 25. The patients admitted to the study had clinical or background information indicating the possibility of a connective tissue disease. Of patients who entered the practice in 1982 and whose details were placed on computer in 1985, 4500 were available for analysis. Each patient had a comprehensive history and physical examination and appropriate laboratory","article-title":"Positive serum samples were tested for antibodies to double stranded DNA by the Farr technique, Sm, RNP, SSA, and SSB.12 C3 and C4 were measured by nephelometry (Smith Kline Bio-Science Laboratories, Atlanta, Georgia). Circulating immune complexes were measured by '25I Clq binding and staphylococci binding assays carried out at the Center for Disease Control.'y'5 The normal range for Clq binding assay is less than 8% and for the staphylococci binding assay less than 25. The patients admitted to the study had clinical or background information indicating the possibility of a connective tissue disease. Of patients who entered the practice in 1982 and whose details were placed on computer in 1985, 4500 were available for analysis. Each patient had a comprehensive history and physical examination and appropriate laboratory"},{"key":"ref_2","first-page":"700","article-title":"The anticentromere antibody: disease specificity and clinical significance","volume-title":"Mayo Clin Proc in each of these categories; With the recent development of the solid phase enzyme linked immunosorbent assay (ELISA) to detect antibodies to the centromere protein, using a","volume":"59","author":"C, Powell F.; K, Winkelmann R.; F, Venencie-Lemarchand; L, Spurbeck J.; L, Schroeter A.","year":"1984","unstructured":"Powell F C, Winkelmann R K, Venencie-Lemarchand F, Spurbeck J L, Schroeter A L. The anticentromere antibody: disease specificity and clinical significance. Mayo Clin Proc in each of these categories. 1984; 59: 700-6. With the recent development of the solid phase enzyme linked immunosorbent assay (ELISA) to detect antibodies to the centromere protein, using a"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1365-2133.1985.tb02351.x","article-title":"Anticentromere antibody: an immunological marker of a subset of systemic sclerosis","volume":"113","author":"P, Chorzelski T.; S, Jablonska; H, Beutner E.","year":"1985","unstructured":"Chorzelski T P, Jablonska S, Beutner E H, et al. Anticentromere antibody: an immunological marker of a subset of systemic sclerosis. Br J Dermatol 1985; 113: 381-9.","journal-title":"Br J Dermatol"},{"key":"ref_4","first-page":"911","article-title":"cloned fusion protein CtermCENP-B[B-gal] as anti-Different antibody patterns and different prognoses in patients gen, one can now detect anticentromere antibody without using indirect immunofluorescence.t9 The presence of other antinuclear antibodies may interwith scleroderma with various extent of skin sclerosis","volume":"13","author":"Giordano, M.; Valentini, G.; Migliaresi, S.; Picillo, U.; Vatti, M.","year":"1986","unstructured":"Giordano M, Valentini G, Migliaresi S, Picillo U, Vatti M. cloned fusion protein CtermCENP-B[B-gal] as anti-Different antibody patterns and different prognoses in patients gen, one can now detect anticentromere antibody without using indirect immunofluorescence.t9 The presence of other antinuclear antibodies may interwith scleroderma with various extent of skin sclerosis. J Rheumatol 1986; 13: 911-6.","journal-title":"J Rheumatol"},{"key":"ref_5","unstructured":"Miller M H, Littlejohn G 0, Davidson A, Jones B, Topliss D J The clinical significance of the anticentromere antibody. Br J fere with the identification of anticentromere anti-Rheumatol 1987; 26: 17-21. body by immunofluorescence. In this paper we were able to identify anticentromere antibody in patients despite the presence of other antinuclear antibodies","article-title":"The clinical significance of the anticentromere antibody. Br J fere with the identification of anticentromere anti-Rheumatol 1987; 26: 17-21. body by immunofluorescence. In this paper we were able to identify anticentromere antibody in patients despite the presence of other antinuclear antibodies"},{"key":"ref_6","first-page":"129","article-title":"Primary biliary cirrhosis and rheumatic diseases: a clinical, immunological and immunogenetical study. Clin Exp Rheumatol","volume":"4","author":"Modena, V.; Marengo, C.; Amoroso, A.","year":"1986","unstructured":"Modena V, Marengo C, Amoroso A, et al. Primary biliary cirrhosis and rheumatic diseases: a clinical, immunological and immunogenetical study. Clin Exp Rheumatol 1986; 4: 129-34."},{"key":"ref_7","first-page":"801","article-title":"Immunobecause of the different sensitivities of the techniques morphological characterization of antinuclear antibodies in used. Using cloned CENP-B, we may be able to identify many more patients. We will see if the observations in this paper continue to be confirmed chronic liver disease","volume":"38","author":"Cassani, F.; Lenzi, Bianchi F.B.; M, Volta; U, Pisi; E.","year":"1985","unstructured":"Cassani F, Bianchi F B. Lenzi M, Volta U, Pisi E. Immunobecause of the different sensitivities of the techniques morphological characterization of antinuclear antibodies in used. Using cloned CENP-B, we may be able to identify many more patients. We will see if the observations in this paper continue to be confirmed chronic liver disease. J Clin Pathol 1985; 38: 801-5.","journal-title":"J Clin Pathol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0190-9622(86)70217-X","article-title":"Anticentromere antibody in localized scleroderma","volume":"15","author":"Ruffatti, A.; Peserico, A.; Glorioso, S.","year":"1986","unstructured":"Ruffatti A, Peserico A, Glorioso S, et al. Anticentromere antibody in localized scleroderma. J Am Acad Dermatol 1986; 15: 637-42.","journal-title":"J Am Acad Dermatol"},{"key":"ref_9","first-page":"89","article-title":"Digital vasculitis associated with centromere antibodies","volume":"29","author":"Leon-Perez, L.; A, Tiliakos N.","year":"1986","unstructured":"Leon-Perez L, Tiliakos N A. Digital vasculitis associated with centromere antibodies [Abstract]. Arthritis Rheum 1986; 29: S89.","journal-title":"Arthritis Rheum"},{"key":"ref_10","first-page":"1076","article-title":"Anticentromere antibody is not specific for connective tissue disease with a promising data indicating scleroderma or CREST should alert the physician to the presence of a potentially serious underlying rheumatic disease process, whereas finding a positive antinuclear antibody may or may prognosis","volume":"28","author":"R, Mitchell S.; A, McCarty G.; P, Katz","year":"1985","unstructured":"Mitchell S R, McCarty G A, Katz P. Anticentromere antibody is not specific for connective tissue disease with a promising data indicating scleroderma or CREST should alert the physician to the presence of a potentially serious underlying rheumatic disease process, whereas finding a positive antinuclear antibody may or may prognosis. Arthritis Rheum 1985; 28: 1076-7.","journal-title":"Arthritis Rheum"},{"key":"ref_11","first-page":"627","article-title":"Detection of immune complexes in unheated sera by a modified '21I-C1q binding test","volume":"116","author":"H, Zubler R.; G, Lange; H, Lambert P.; A, Miescher P.","year":"1979","unstructured":"Zubler R H, Lange G, Lambert P H, Miescher P A. Detection of immune complexes in unheated sera by a modified '21I-C1q binding test. J Immunol 1979; 116: 627-36.","journal-title":"J Immunol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1172\/JCI109345","article-title":"Binding of immunoglobulin G aggregates and immune complexes in human sera to staphylococci containing protein A","volume":"63","author":"B, McDougal J.S.Redecha P.; D, Inman R.; L, Christian C.","year":"1979","unstructured":"McDougal J S. Redecha P B, Inman R D, Christian C L. Binding of immunoglobulin G aggregates and immune complexes in human sera to staphylococci containing protein A. J Clin Invest 1979; 63: 627-36.","journal-title":"J Clin Invest"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1002\/art.1780251003","article-title":"Comparison of five assays for immune complexes in the rheumatic diseases: an assessment of their validity for rheumatoid arthritis","volume":"25","author":"S, McDougal J.; M, Hubbard; C, McDuffie F.","year":"1982","unstructured":"McDougal J S, Hubbard M, McDuffie F C, et al. Comparison of five assays for immune complexes in the rheumatic diseases: an assessment of their validity for rheumatoid arthritis. 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Published by Elsevier B.V. on behalf of European Alliance of Associations for Rheumatology, EULAR. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}