{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:56:48Z","timestamp":1770980208112,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1991,6,1]],"date-time":"1991-06-01T00:00:00Z","timestamp":675734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1991,6,1]],"date-time":"1991-06-01T00:00:00Z","timestamp":675734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[1991,6]]},"DOI":"10.1136\/ard.50.6.376","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T23:49:46Z","timestamp":1217288986000},"page":"376-378","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Serum selenium concentrations in rheumatoid arthritis."],"prefix":"10.1016","volume":"50","author":[{"given":"J.R","family":"O'Dell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Lemley-Gillespie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.R","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.L","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.F","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.W","family":"Klassen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1021\/ja01569a087","article-title":"Selenium as an integral part of factor 3 against dietary necrotic liver degeneration","volume":"79","author":"Schwarz, K.; M, Foltz C.","year":"1957","unstructured":"Schwarz K, Foltz C M. Selenium as an integral part of factor 3 against dietary necrotic liver degeneration. Jowunal of the American Chemical Society 1957; 79: 3292-3.","journal-title":"Jowunal of the American Chemical Society"},{"key":"ref_2","first-page":"617","volume-title":"Effect of selenium in preventing exudative diathesis in chicks. Proc Soc Exp Biol Med","volume":"95","author":"L, Patterson E.","year":"1957","unstructured":"Patterson E L, Milstrey R, Stoksfad E L R. Effect of selenium in preventing exudative diathesis in chicks. Proc Soc Exp Biol Med 1957; 95: 617-20."},{"key":"ref_3","first-page":"621","article-title":"Prevention of exudative diathesis in chicks by factor 3","volume-title":"and selenium. Proc Soc Exp Biol Med","volume":"95","author":"Schwarz, K.; G, Bieri J.; M, Briggs G.; L, Scott M.","year":"1957","unstructured":"Schwarz K, Bieri J G, Briggs G M, Scott M L. Prevention of exudative diathesis in chicks by factor 3 and selenium. Proc Soc Exp Biol Med 1957; 95: 621-5."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","article-title":"Selenium: biochemical role as a component of glutathione peroxidase","volume":"179","author":"T, Rotruck J.; L, Pope A.; F, Ganther H.; B, Swanson A.; G, Hafeman D.; G, Hoekstra W.","year":"1973","unstructured":"Rotruck J T, Pope A L, Ganther H F, Swanson A B, Hafeman D G, Hoekstra W G. Selenium: biochemical role as a component of glutathione peroxidase. Science 1973; 179: 588-90.","journal-title":"Science"},{"key":"ref_5","first-page":"240","article-title":"Selenium in nutritional cancer prophylaxis: an update","volume-title":"nutrition and cancer","author":"N, Schrauzer G.","year":"1984","unstructured":"Schrauzer G N. Selenium in nutritional cancer prophylaxis: an update. In: Prasad K N, ed. Vitamins, nutrition and cancer. Basel: Karger, 1984: 240-50."},{"key":"ref_6","first-page":"305","article-title":"Selenium and cancer prevention","volume":"10","author":"J, Helzlsouer K.","year":"1983","unstructured":"Helzlsouer K J. Selenium and cancer prevention. Semin Oncol 1983; 10: 305-10.","journal-title":"Semin Oncol"},{"key":"ref_7","first-page":"130","article-title":"Prediagnostic serum selenium and risk of cancer","volume":"ii:","author":"C, Willett W.; S, Morris J.; S, Pressel","year":"1983","unstructured":"Willett W C, Morris J S, Pressel S, et al. Prediagnostic serum selenium and risk of cancer. Lancet 1983; ii: 130-4.","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1136\/bmj.290.6466.417","article-title":"Risk of cancer in relation to serum concentrations of selenium and vitamins A and E: matched case-control analysis of prospective data","volume":"290","author":"T, Salonen J.; R, Salonen; R, Lappetelainen; H, Maenpaa P.; G, Alfthan; P, Puska","year":"1985","unstructured":"Salonen J T, Salonen R, Lappetelainen R, Maenpaa P H, Alfthan G, Puska P. Risk of cancer in relation to serum concentrations of selenium and vitamins A and E: matched case-control analysis of prospective data. BMJ 1985; 290: 417-20.","journal-title":"BMJ"},{"key":"ref_9","first-page":"127","article-title":"The mechanism of inhibition ofin vitro mitogenesis by selenium. Clin Res 1987; 35: 855A. 10 Petrie","volume":"11","author":"R, O.'Dell J.; S, Lemley-Gillespie; D, Kay H.; W, Klassen L.","year":"1986","unstructured":"O'Dell J R, Lemley-Gillespie S, Kay H D, Klassen L W. The mechanism of inhibition ofin vitro mitogenesis by selenium. Clin Res 1987; 35: 855A. 10 Petrie H T, Tempero M A, Klassen L W, Kay H D. In vitro regulation of human lymphocyte proliferation by selenium. Biological and Trace Elements Research 1986; 11: 127.","journal-title":"Biological and Trace Elements Research; vitro regulation of human lymphocyte proliferation by selenium"},{"key":"ref_10","first-page":"5496","article-title":"Effects of selenium on cell proliferation in rat liver and mammalian cells as indicated by cytokinetic and biochemistry analysis","volume":"45","author":"A, Leboeuf R.; A, Laishes B.; G, Hoekstra W.","year":"1985","unstructured":"Leboeuf R A, Laishes B A, Hoekstra W G. Effects of selenium on cell proliferation in rat liver and mammalian cells as indicated by cytokinetic and biochemistry analysis. Cancer Res 1985; 45: 5496-504.","journal-title":"Cancer Res"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BF02917600","article-title":"Selenium retention and inhibition of cell growth in mouse mammary epithelial cell lines in vitro","volume":"8","author":"Medina, D.; Morrison, D.; J, Oborn C.","year":"1985","unstructured":"Medina D, Morrison D, Oborn C J. Selenium retention and inhibition of cell growth in mouse mammary epithelial cell lines in vitro. Biological and Trace Elements Research 1985; 8: 19-35.","journal-title":"Biological and Trace Elements Research"},{"key":"ref_12","first-page":"500","article-title":"Antiinflammation studies. II. Antiinflammatory properties of selenium","volume":"5","author":"F, Roberts M.","year":"1963","unstructured":"Roberts M F. Antiinflammation studies. II. Antiinflammatory properties of selenium. Toxicol Appl Pharmacol 1963; 5: 500-6.","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1007\/BF01989914","article-title":"Sodium selenite inhibition of the reproduction of some oncogenic RNA-viruses","volume":"37","author":"M, Balansky R.; M, Argirova R.","year":"1981","unstructured":"Balansky R M, Argirova R M. Sodium selenite inhibition of the reproduction of some oncogenic RNA-viruses. Experientia 1981; 37: 1194-5.","journal-title":"Experientia"},{"key":"ref_14","first-page":"229","article-title":"Effect of dietary selenium on the primary and secondary immune response in calves challenged with infectious bovine rhinotracheitis virus","author":"K, Reffett J.; Jr","year":"1987","unstructured":"Reffett J K, Spears J W, Brown T T Jr. Effect of dietary selenium on the primary and secondary immune response in calves challenged with infectious bovine rhinotracheitis virus. American Institute of Nutrition 1987: 229-35."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3109\/03009747809095662","article-title":"Trace elements in serum and urine of patients with rheumatoid arthritis","volume":"7","year":"1978","unstructured":"Aaseth J, Munthe E T, Forre 0, Steinnes E. Trace elements in serum and urine of patients with rheumatoid arthritis. Scand J Rheumatol 1978; 7: 237-40.","journal-title":"Scand J Rheumatol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3109\/03009748509165490","article-title":"Low selenium level in severe rheumatoid arthritis","volume":"14","author":"Tarp, U.; Overvad, K.; C, Hansen J.; B, Thorling E.","year":"1985","unstructured":"Tarp U, Overvad K, Hansen J C, Thorling E B. Low selenium level in severe rheumatoid arthritis. Scand J Rheumatol 1985; 14: 97-101.","journal-title":"Scand J Rheumatol"},{"key":"ref_17","first-page":"315","article-title":"revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"C, Arnett F.; M, Edworthy S.; A, Bloch D.","year":"1987","unstructured":"Arnett F C, Edworthy S M, Bloch D A, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-24.","journal-title":"The American Rheumatism Association"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1021\/ac60329a040","article-title":"Optimum procedure for the determination of selenium in biological specimens using 77m Se neutron activation","volume":"45","author":"J, Blotcky A.; J, Arsenault L.; P, Rack E.","year":"1973","unstructured":"Blotcky A J, Arsenault L J, Rack E P. Optimum procedure for the determination of selenium in biological specimens using 77m Se neutron activation. Anal Chem 1973; 45: 1056-60.","journal-title":"Anal Chem"},{"key":"ref_19","first-page":"1104","article-title":"Selenium status in relation to clinical variables and corticosteroid treatment in rheumatoid arthritis","volume":"14","author":"Peretz, A.; Neve, J.; Vertongen, F.; P, Famaey J.; Molle, L.","year":"1987","unstructured":"Peretz A, Neve J, Vertongen F, Famaey J P, Molle L. Selenium status in relation to clinical variables and corticosteroid treatment in rheumatoid arthritis. J Rheumatol 1987; 14: 1104-7.","journal-title":"J Rheumatol"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3109\/03009748509100414","article-title":"Selenium status in patients with rheumatoid arthritis","volume":"14","author":"Sonne, M.; T, Jense P.; Helieberg, L.","year":"1985","unstructured":"Sonne M, Jense P T, Helieberg L. Selenium status in patients with rheumatoid arthritis. Scand J Rheumatol 1985; 14: 318-9.","journal-title":"Scand J Rheumatol"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/oxfordjournals.epirev.a036238","article-title":"Adult and juvenile rheumatoid arthritis: current epidemiologic concepts","volume":"3","author":"C, Hochberg M.","year":"1981","unstructured":"Hochberg M C. Adult and juvenile rheumatoid arthritis: current epidemiologic concepts. Epidemiol Rev 1981; 3: 27-44.","journal-title":"Epidemiol Rev"},{"key":"ref_22","first-page":"605","article-title":"Clinical picture of rheumatoid arthritis","volume-title":"allied conditions","author":"C, Williams R.; J, McCarty D.","year":"1985","unstructured":"Williams R C, McCarty D J. Clinical picture of rheumatoid arthritis. In: McCarty D J ed. Arthritis and allied conditions. 10th ed. Philadelphia: Lea and Febiger, 1985: 605-19.","edition":"10th ed"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3109\/03009748509102039","article-title":"Selenium treatment in rheumatoid arthritis","volume":"14","author":"Tarp, U.; Overvad, K.; B, Thorling E.; Graudal, H.; C, Hansen J.","year":"1985","unstructured":"Tarp U, Overvad K, Thorling E B, Graudal H, Hansen J C. Selenium treatment in rheumatoid arthritis. Scand J Rheumatol 1985; 14: 364-8.","journal-title":"Scand J Rheumatol"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1002\/art.1780301012","article-title":"Glutathione peroxidase activity in patients with rheumatoid arthritis and in normal subjects: effects of longterm selenium supplementation","volume":"30","author":"Tarp, U.; C, Hansen J.; Overvad, K.; B, Thorling E.; D, Tarp B.; Graudal, H.","year":"1987","unstructured":"Tarp U, Hansen J C, Overvad K, Thorling E B, Tarp B D, Graudal H. Glutathione peroxidase activity in patients with rheumatoid arthritis and in normal subjects: effects of longterm selenium supplementation. Arthritis Rheum 1987; 30: 1162-6.","journal-title":"Arthritis Rheum"},{"key":"ref_25","first-page":"322","article-title":"Improved survival in murine lupus as the result of selenium supplementation. Clin Exp Immunol","volume":"73","author":"R, O.'Dell J.; P, McGivern J.; D, Kay H.; W, Klassen L.","year":"1988","unstructured":"O'Dell J R, McGivern J P, Kay H D, Klassen L W. Improved survival in murine lupus as the result of selenium supplementation. Clin Exp Immunol 1988; 73: 322-7."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/0192-0561(83)90022-X","article-title":"Macrophage, lymphocyteand chronic inflammatory responses in selenium deficient rodents. Association with decreased glutathione peroxidase activity","volume":"5","author":"J, Parnham M.; I, Winkelmann; S, Leyck","year":"1983","unstructured":"Parnham M J, Winkelmann I, Leyck S. Macrophage, lymphocyteand chronic inflammatory responses in selenium deficient rodents. Association with decreased glutathione peroxidase activity. IntJ Immunopharmacol 1983; 5: 455.","journal-title":"IntJ Immunopharmacol"},{"key":"ref_27","first-page":"91","article-title":"A study of Kashin-Beck disease associated with environmental selenium in Shanxi area","volume":"2","author":"Li, J.; Ren, S.; Chen, D.","year":"1982","unstructured":"Li J, Ren S, Chen D. A study of Kashin-Beck disease associated with environmental selenium in Shanxi area. Hunajing Kexue Xuebao 1982; 2: 91-101.","journal-title":"Hunajing Kexue Xuebao"},{"key":"ref_28","first-page":"1299","article-title":"Selenium inhibition of N-methyl- N-nitrosurea-induced mammary carcinogenesis in the rat","volume":"65","author":"J, Thompson H.; J, Becci P.","year":"1980","unstructured":"Thompson H J, Becci P J. Selenium inhibition of N-methyl- N-nitrosurea-induced mammary carcinogenesis in the rat. J Natil Cancer Inst 1980; 65: 1299-301.","journal-title":"J Natil Cancer Inst"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3109\/15563657308990545","article-title":"Relationship of dietary selenium concentrations, chemical cancer induction and tissue concentration of selenium in rats","volume":"6","author":"R, Harr J.; H, Exon J.; H, Weswig P.","year":"1973","unstructured":"Harr J R, Exon J H, Weswig P H, et al. Relationship of dietary selenium concentrations, chemical cancer induction and tissue concentration of selenium in rats. Clinical Toxicologh 1973; 6: 487-95.","journal-title":"Clinical Toxicologh"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/carcin\/2.5.451","article-title":"Selenium-mediated inhibition of 7,12-dimethylbenzalanthracene-induced mouse mammary tumorigenesis","volume":"2","author":"Medina, D.; Shepherd, F.","year":"1981","unstructured":"Medina D, Shepherd F. Selenium-mediated inhibition of 7,12-dimethylbenzalanthracene-induced mouse mammary tumorigenesis. Carcinogenesis 1981; 2: 451-5.","journal-title":"Carcinogenesis"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF02798589","article-title":"Studies on the relations of selenium and Keshan disease","volume":"2","author":"Chen, X.; Yang, G.; Chen, J.; Chen, X.; Wen, Z.; Ge, K.","year":"1980","unstructured":"Chen X, Yang G, Chen J, Chen X, Wen Z, Ge K. Studies on the relations of selenium and Keshan disease. Biological and Trace Elements Research 1980; 2: 91-107.","journal-title":"Biological and Trace Elements Research"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1056\/NEJM198105143042005","article-title":"An occidental case of cardiomyopathy and selenium deficiency","volume":"304","author":"A, Johnson R.; S, Baker S.; T, Falon J.","year":"1981","unstructured":"Johnson R A, Baker S S, Falon J T, et al. An occidental case of cardiomyopathy and selenium deficiency. N EnglJ_ Med 1981; 304: 1210-2.","journal-title":"N EnglJ_ Med"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724108552?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724108552?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.50.6.376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T07:53:51Z","timestamp":1737446031000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724108552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,6]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1991,6]]}},"alternative-id":["S0003496724108552"],"URL":"https:\/\/doi.org\/10.1136\/ard.50.6.376","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[1991,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum selenium concentrations in rheumatoid arthritis.","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.50.6.376","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1991 \u00a9 THE AUTHORS. Published by Elsevier B.V. on behalf of European Alliance of Associations for Rheumatology, EULAR. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}