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Since then aspirin has been used initially (up to 4800 mg\/day) for two to three weeks. Indomethacin (up to 150 mg\/day) is added if there is no response and is continued for four to six weeks. During this time patients also receive paracetamol. If there is no response at the end of six to eight weeks, then corticosteroids are used. The complications are treated as required. Eight patients (44%) required corticosteroids for control of their systemic disease and complications.","article-title":"Treatment varied before the prospective study started in 1983. Since then aspirin has been used initially (up to 4800 mg\/day) for two to three weeks. Indomethacin (up to 150 mg\/day) is added if there is no response and is continued for four to six weeks. During this time patients also receive paracetamol. If there is no response at the end of six to eight weeks, then corticosteroids are used. The complications are treated as required. 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