{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:41:50Z","timestamp":1791103310142,"version":"4.1.0"},"reference-count":15,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1993,3,1]],"date-time":"1993-03-01T00:00:00Z","timestamp":730944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1993,3,1]],"date-time":"1993-03-01T00:00:00Z","timestamp":730944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[1993,3]]},"DOI":"10.1136\/ard.52.3.232","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T23:49:46Z","timestamp":1217288986000},"page":"232-234","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":289,"title":["Serum interleukin 6 levels in rheumatoid arthritis: correlations with clinical and laboratory indices of disease activity."],"prefix":"10.1016","volume":"52","author":[{"given":"R","family":"Madhok","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Crilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.A","family":"Capell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"ref_1","first-page":"3342","article-title":"Quantitative analysis of cytokine gene expression in rheumatoid arthritis._ Immunol","volume":"144","author":"S, Firestein G.; M, Alavro-Garcia J.; R, Maki","year":"1990","unstructured":"Firestein G S, Alavro-Garcia J M, Maki R. Quantitative analysis of cytokine gene expression in rheumatoid arthritis._ Immunol 1990; 144: 3342-53."},{"key":"ref_2","first-page":"169","article-title":"The cytokine handbook","author":"Hirano, T.","year":"1991","unstructured":"Hirano T. Interleukin-6. In: Thomson A, ed. The cytokine handbook. London: Academic Press, 1991: 169-91."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/art.1780310614","article-title":"Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritis","volume":"31","author":"A, Houssiau F.; de Vogelaer J P; van Damme J; de Deuxchaisnes C N; van Snick J","year":"1988","unstructured":"Houssiau F A, de Vogelaer J P, van Damme J, de Deuxchaisnes C N, van Snick J. Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritis. Arthritis Rheum 1988; 31: 784-7.","journal-title":"Arthritis Rheum"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.4049\/jimmunol.143.7.2153","article-title":"IL-6\/IFN B2 in synovial effusions of patients with rheumatoid arthritis and other inflammatory arthritidies","volume":"143","author":"Bhardwaj, N.; Santhanam, U.; L, Lau L.","year":"1989","unstructured":"Bhardwaj N, Santhanam U, Lau L L, et al. IL-6\/IFN B2 in synovial effusions of patients with rheumatoid arthritis and other inflammatory arthritidies. Jlmmunol 1989; 143: 2153-9.","journal-title":"Jlmmunol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1172\/JCI113921","article-title":"Synovium as a source of interleukin-6 in vitro","volume":"83","author":"A, Gurne P.; L, Zuraw B.; H, Vaughan J.; A, Carson D.; M, Lotz","year":"1989","unstructured":"Gurne P A, Zuraw B L, Vaughan J H, Carson D A, Lotz M. Synovium as a source of interleukin-6 in vitro. Jf Clin Invest 1989; 83: 585-92.","journal-title":"Jf Clin Invest"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1002\/eji.1830181010","article-title":"Functional discrimination between interleukin-6 and interleukin-1","volume":"18","author":"Helle, M.; Boeije, L.; A, Aarden L.","year":"1988","unstructured":"Helle M, Boeije L, Aarden L A. Functional discrimination between interleukin-6 and interleukin-1. Eur Jf Immunol 1988; 18: 1535-40.","journal-title":"Eur Jf Immunol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1365-2362.1991.tb01398.x","article-title":"Relationships between local inflammation, interleukin-6 concentration and the acute phase response in arthritis patients","volume":"21","author":"Holte, I.; G, Cooper R.; J, Hopkins S.","year":"1991","unstructured":"Holte I, Cooper R G, Hopkins S J. Relationships between local inflammation, interleukin-6 concentration and the acute phase response in arthritis patients. EurJ Clin Invest 1991; 21: 479-84.","journal-title":"EurJ Clin Invest"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3109\/03009748809098809","article-title":"IL-6 in synovial fluid and serum of patients with rheumatic diseases","volume":"17","author":"J, Swaak A.; A, Van Rooyen; E, Nieuwenhuis; A, Aarden L.","year":"1988","unstructured":"Swaak A J, Van Rooyen A, Nieuwenhuis E, Aarden L A. IL-6 in synovial fluid and serum of patients with rheumatic diseases. ScandJ Rheumatol 1988; 17: 469-74.","journal-title":"ScandJ Rheumatol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/art.1780300603","article-title":"Articular indices of joint inflammation in rheumatoid arthritis. Correlation with the acute phase response","volume":"30","author":"W, Thompson P.; R, Kirwan J.; F, Currey H.L.","year":"1987","unstructured":"Thompson P W, Kirwan J R, Currey H L F. Articular indices of joint inflammation in rheumatoid arthritis. Correlation with the acute phase response. Arthnitis Rheum 1987; 30: 618-23.","journal-title":"Arthnitis Rheum"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1136\/ard.47.3.183","article-title":"Value of joint scintigraphy in prediction of erosiveness in early rheumatoid arthritis","volume":"47","author":"T, Mottonen T.; P, Hannonen; J, Toivanen; A, Rekonen; M, Oka","year":"1988","unstructured":"Mottonen T T, Hannonen P, Toivanen J, Rekonen A, Oka M. Value of joint scintigraphy in prediction of erosiveness in early rheumatoid arthritis. Ann Rheum Dis 1988; 47: 183-9.","journal-title":"Ann Rheum Dis"},{"key":"ref_11","article-title":"Gold therapy lowers interleukin-6","author":"Madhok, R.; Crilly, A.; Murphy, E.; Smith, J.; Watson, J.; C, Capell H.","unstructured":"Madhok R, Crilly A, Murphy E, Smith J, Watson J, Capell H C. Gold therapy lowers interleukin-6 levels in rheumatoid arthritis. J. Rheumatol. In press."},{"key":"ref_12","first-page":"22","article-title":"Serial estimation of interleukin 6 as a measure of systemic disease in RA","volume":"19","author":"Dasgupta, B.; Corkill, M.; Kirkham, B.; Gibson, T.; Panayi, G.","year":"1992","unstructured":"Dasgupta B, Corkill M, Kirkham B, Gibson T, Panayi G. Serial estimation of interleukin 6 as a measure of systemic disease in RA. J Rheumatol 1992; 19: 22-6.","journal-title":"J Rheumatol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3773","DOI":"10.1002\/j.1460-2075.1989.tb08554.x","article-title":"Dual control of C-reactive protein gene expression by interleukin-1 and interleukin-6","volume":"8","author":"Gatner, U.; Arcone, R.; Toniatti, C.; Morrone, G.; Ciliberto, G.","year":"1989","unstructured":"Gatner U, Arcone R, Toniatti C, Morrone G, Ciliberto G. Dual control of C-reactive protein gene expression by interleukin-1 and interleukin-6. EMBO J 1989; 8: 3773-9.","journal-title":"EMBO J"},{"key":"ref_14","first-page":"1491","article-title":"Transforming growth factor beta-I regulates production of","volume-title":"acute phase proteins. Proc NadAcad Sci USA","volume":"87","author":"Mackiewicz, A.; K, Ganapathi M.; Schultz, D.","year":"1990","unstructured":"Mackiewicz A, Ganapathi M K, Schultz D, et al. Transforming growth factor beta-I regulates production of acute phase proteins. Proc NadAcad Sci USA 1990; 87: 1491-5."},{"key":"ref_15","first-page":"286","article-title":"Elevated serum interleukin-6 levels in patients with reactive thrombocytosis","volume":"79","author":"W, Hollen C.; J, Hentthron; A, Koziol J.; A, Burstein S.","year":"1991","unstructured":"Hollen C W, Hentthron J, Koziol J A, Burstein S A. Elevated serum interleukin-6 levels in patients with reactive thrombocytosis. Br3'Haematol 1991; 79: 286-90."}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724033715?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724033715?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.52.3.232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T06:22:12Z","timestamp":1738304532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724033715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,3]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,3]]}},"alternative-id":["S0003496724033715"],"URL":"https:\/\/doi.org\/10.1136\/ard.52.3.232","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[1993,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum interleukin 6 levels in rheumatoid arthritis: correlations with clinical and laboratory indices of disease activity.","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.52.3.232","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1993 \u00a9 THE AUTHORS. Published by Elsevier B.V. on behalf of European Alliance of Associations for Rheumatology, EULAR. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}