{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T04:41:20Z","timestamp":1761021680106,"version":"3.35.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1993,4,1]],"date-time":"1993-04-01T00:00:00Z","timestamp":733622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1993,4,1]],"date-time":"1993-04-01T00:00:00Z","timestamp":733622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[1993,4]]},"DOI":"10.1136\/ard.52.4.292","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T23:49:46Z","timestamp":1217288986000},"page":"292-299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effect of tenidap on cartilage integrity in vitro."],"prefix":"10.1016","volume":"52","author":[{"given":"J.T","family":"Dingle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.R","family":"Leeming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.J","family":"Martindale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"ref_1","first-page":"201","article-title":"Recent studies on the control of joint damage","volume":"38","author":"T, Dingle J.","year":"1979","unstructured":"Dingle J T. Recent studies on the control of joint damage. Ann Rheum Dis 1979; 38: 201-14.","journal-title":"Ann Rheum Dis"},{"key":"ref_2","first-page":"69","article-title":"Interleukin, immunity and inflammation","volume-title":"The control oftissue damage","author":"B, Mizel S.","year":"1988","unstructured":"Mizel S B. Interleukin, immunity and inflammation. In: Glauert A M, ed. The control oftissue damage. Amsterdam: Elsevier, 1988: 69-75."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/322547a0","article-title":"Tumour necrosis factor stimulates resorption and inhibits synthesis of proteoglycan in cartilage","volume":"322","author":"Saklatvala, J.","year":"1986","unstructured":"Saklatvala J. Tumour necrosis factor stimulates resorption and inhibits synthesis of proteoglycan in cartilage. Nature 1986; 322: 547-9.","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0174-173X(85)80033-9","article-title":"Mononuclear cell-conditioned medium containing mononuclear cell factor homologous with interleukin 1 stimulates collagen and fibronectin synthesis by adherent rheumatoid synovial cells: effects of prostaglandin E2 and indomethacin","volume":"5","author":"M, Krane S.; J-M, Dayer; S, Simon L.; S, Byrne","year":"1985","unstructured":"Krane S M, Dayer J-M, Simon L S, Byrne S. Mononuclear cell-conditioned medium containing mononuclear cell factor homologous with interleukin 1 stimulates collagen and fibronectin synthesis by adherent rheumatoid synovial cells: effects of prostaglandin E2 and indomethacin. Collagen Related Research 1985; 5: 99-117.","journal-title":"Collagen Related Research"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1042\/bj2150385","article-title":"Purification to homogeneity of pig leucocyte catabolin, a protein that causes cardlage resorption in vitro","volume":"215","author":"Saklatvala, J.; A, Curry V.; J, Sarsfield S.","year":"1983","unstructured":"Saklatvala J, Curry V A, Sarsfield S J. Purification to homogeneity of pig leucocyte catabolin, a protein that causes cardlage resorption in vitro. BiochemJ 1983; 215: 385-92.","journal-title":"BiochemJ"},{"key":"ref_6","first-page":"68","article-title":"Interleukin 1: amino acid sequences, multiple biological activities and comparison with tumour necrosis factor (cachectin)","volume-title":"The year in immunology","volume":"2","author":"A, Dinarello C.","year":"1986","unstructured":"Dinarello C A. Interleukin 1: amino acid sequences, multiple biological activities and comparison with tumour necrosis factor (cachectin). In: Cruse J M, Lewis R E, eds. The year in immunology. Vol. 2. Basle: Karger, 1986: 68-89."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/324263a0","article-title":"Identification of a common class of high-affinity receptors for both types of porcine interleukin 1 on connective tissue cells","volume":"324","author":"A, Bird T.; J, Saklatvala","year":"1986","unstructured":"Bird T A, Saklatvala J. Identification of a common class of high-affinity receptors for both types of porcine interleukin 1 on connective tissue cells. Nature 1986; 324: 263-6.","journal-title":"Nature"},{"key":"ref_8","article-title":"The influence of interleukin 1 and insulin-like growth factor 1 on the integrity of cartilage matrix","volume-title":"The control oftissue damage","author":"A, Tyler J.","year":"1988","unstructured":"Tyler J A. The influence of interleukin 1 and insulin-like growth factor 1 on the integrity of cartilage matrix. In: Glauert A M, ed. The control oftissue damage. Amsterdam: Elsevier, 1988: 197-219."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3109\/03008208409013690","article-title":"The effect of synovial catabolin on cartilage synthetic activity","volume":"12","author":"T, Dingle J.","year":"1984","unstructured":"Dingle J T. The effect of synovial catabolin on cartilage synthetic activity. Connect Tissue Res 1984; 12: 277-86.","journal-title":"Connect Tissue Res"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1042\/bj2270869","article-title":"Articular cartilage cultured with catabolin (pig interleukin 1) synthesizes a decreased number of normal proteoglycan molecules","volume":"277","author":"A, Tyler J.","year":"1985","unstructured":"Tyler J A. Articular cartilage cultured with catabolin (pig interleukin 1) synthesizes a decreased number of normal proteoglycan molecules. BiochemJ 1985; 277: 869-78.","journal-title":"BiochemJ"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1042\/bj2250493","article-title":"Chondrocyte-mediated depletion of articulated cartilage proteoglycans in vitro","volume":"225","author":"A, Tyler J.","year":"1985","unstructured":"Tyler J A. Chondrocyte-mediated depletion of articulated cartilage proteoglycans in vitro. Biochem J 1985; 225: 493-507.","journal-title":"Biochem J"},{"key":"ref_12","first-page":"763","article-title":"The injury and repair of human articular cartilage: a morphological study of 192 cases of osteoarthritis","volume":"60","author":"Nakata, K.; G, Bullough P.","year":"1986","unstructured":"Nakata K, Bullough P G. The injury and repair of human articular cartilage: a morphological study of 192 cases of osteoarthritis. Journal of the Japanese Orthopaedic Association 1986; 60: 763-75.","journal-title":"Journal of the Japanese Orthopaedic Association"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/ard.50.2.75","article-title":"In vivo studies of cartilage regeneration after damage induced by catabolinIL-1","volume":"50","author":"P, Page Thomas D.; B, King; T, Stephens; T, Dingle J.","year":"1991","unstructured":"Page Thomas D P, King B, Stephens T, Dingle J T. In vivo studies of cartilage regeneration after damage induced by catabolinIL-1. Ann Rheum Dis 1991; 50: 75-82.","journal-title":"Ann Rheum Dis"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0002-9343(87)90848-5","article-title":"Effects of non-steroidal anti-inflammatory drugs on the metabolism in vitro and in vivo","volume":"83","author":"D, Brandt K.","year":"1987","unstructured":"Brandt K D. Effects of non-steroidal anti-inflammatory drugs on the metabolism in vitro and in vivo. Am Jf Med 1987; 83: 29-34.","journal-title":"Am Jf Med"},{"key":"ref_15","first-page":"75","article-title":"In vitro effects of select non-steroidal anti-inflammatory drugs on the synthesis and activity of anabolic regulatory factors produced by osteoarthritic and rheumatoid synovial tissue","volume":"16","author":"H, Herman J.; M, Appel A.; C, Khosla R.; V, Hess E.","year":"1989","unstructured":"Herman J H, Appel A M, Khosla R C, Hess E V. In vitro effects of select non-steroidal anti-inflammatory drugs on the synthesis and activity of anabolic regulatory factors produced by osteoarthritic and rheumatoid synovial tissue.JRheumatol 1989; 16: 75-81.","journal-title":"JRheumatol"},{"issue":"5","key":"ref_16","first-page":"36","article-title":"Cartilage metabolism and antiinflammatory drugs in osteoarthritis","volume":"81","author":"V, Hess E.; H, Herman J.","year":"1986","unstructured":"Hess E V, Herman J H. Cartilage metabolism and antiinflammatory drugs in osteoarthritis. AmJMed 1986; 81 (suppl 5B): 36-43.","journal-title":"AmJMed"},{"key":"ref_17","first-page":"13","article-title":"The influence of NSAIDs on morphology of articular cartilage","volume":"77","author":"A, Kalben D.","year":"1989","unstructured":"Kalben D A. The influence of NSAIDs on morphology of articular cartilage. Scand Jf Rheumatol Suppl 1989; 77: 13-22.","journal-title":"Scand Jf Rheumatol Suppl"},{"key":"ref_18","first-page":"17","article-title":"The influence of a novel arachidonate inhibitor, CP-66,248 on the production and activity of human monocyte IL-1","volume":"4","author":"McDonald, B.; Loose, L.; J, Rosenwasser L.","year":"1988","unstructured":"McDonald B, Loose L, Rosenwasser L J. The influence of a novel arachidonate inhibitor, CP-66,248 on the production and activity of human monocyte IL-1. Arthritis Rheum 1988; 31 (suppl 4): S17.","journal-title":"Arthritis Rheum"},{"key":"ref_19","first-page":"90","article-title":"Effect of CP-66,248 on IL-1 synthesis by murine peritoneal macrophages","volume":"4","author":"G, Otterness I.; L, Bliven M.; T, Downs J.; C, Hanson D.","year":"1988","unstructured":"Otterness I G, Bliven M L, Downs J T, Hanson D C. Effect of CP-66,248 on IL-1 synthesis by murine peritoneal macrophages. Arthritis Rheum 1988; 31 (suppl 4): S90.","journal-title":"Arthritis Rheum"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1136\/ard.34.4.303","article-title":"Breakdown of proteoglycan and collagen induced in pig articular cartilage in organ culture","volume":"34","author":"T, Dingle J.; P, Horsfield; B, Fell H.; J, Barratt M.E.","year":"1975","unstructured":"Dingle J T, Horsfield P, Fell H B, Barratt M E J. Breakdown of proteoglycan and collagen induced in pig articular cartilage in organ culture. Ann Rheum Dis 1975; 34: 303-11.","journal-title":"Ann Rheum Dis"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1002\/art.1780200710","article-title":"The effect of synovial tissue on the breakdown of articular cartilage in organ culture","volume":"20","author":"B, Fell H.; W, Jubb R.","year":"1977","unstructured":"Fell H B, Jubb R W. The effect of synovial tissue on the breakdown of articular cartilage in organ culture. Arthritis Rheum 1977; 20: 1359-63.","journal-title":"Arthritis Rheum"},{"key":"ref_22","first-page":"339","article-title":"The role ofneutral and acidproteinases in connective tissue turnover in proteoglycan and physiological regulation","author":"T, Dingle J.","year":"1977","unstructured":"Dingle J T. The role ofneutral and acidproteinases in connective tissue turnover in proteoglycan and physiological regulation. New York: Academic Press, 1977: 339-55."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/03008208209160269","article-title":"A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage culture","volume":"9","author":"W, Farndale R.; A, Sayers C.; J, Barrett A.","year":"1982","unstructured":"Farndale R W, Sayers C A, Barrett A J. A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage culture. Connect Tissue Res 1982; 9: 247-8.","journal-title":"Connect Tissue Res"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/BF01037953","article-title":"Plasma and synovial fluid concentrations of diclofenac sodium and its major hydroxylated metabolites during long term treatment of rheumatoid arthritis","volume":"25","author":"D, Fowler P.; F, Shadforth M.; R, Crook P.; A, John V.","year":"1983","unstructured":"Fowler P D, Shadforth M F, Crook P R, John V A. Plasma and synovial fluid concentrations of diclofenac sodium and its major hydroxylated metabolites during long term treatment of rheumatoid arthritis. Eur Jf Clin Pharmacol 1983; 25: 389-94.","journal-title":"Eur Jf Clin Pharmacol"},{"key":"ref_25","first-page":"155","article-title":"Naproxen concentrations in serum, synovial fluid and synovium","volume":"6","author":"Jalava, S.; Saarimaa, H.; Anttila, M.; Sundquist, H.","year":"1977","unstructured":"Jalava S, Saarimaa H, Anttila M, Sundquist H. Naproxen concentrations in serum, synovial fluid and synovium. ScandJRheumatol 1977; 6: 155-7.","journal-title":"ScandJRheumatol"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/978-94-011-2982-4_31","article-title":"NSAIDs and human cartilage metabolism","volume-title":"Side-effects of antiinflammatory drugs","author":"T, Dingle J.","year":"1992","unstructured":"Dingle J T. NSAIDs and human cartilage metabolism. In: Rainsford K D and Velo G P, eds. Side-effects of antiinflammatory drugs. London: Kluwer, 1992: 261-8."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/art.1780340212","article-title":"Inhibition of 5-lipoxygenase product formation and polymorphonuclear cell degranulation by tenidap sodium in patients with rheumatoid arthritis","volume":"34","author":"D, Blackbum W.; W, Heck L.; D, Loose L.; J, Eskra; J, Carty T.","year":"1991","unstructured":"Blackbum W D, Heck L W, Loose L D, Eskra J, Carty T J. Inhibition of 5-lipoxygenase product formation and polymorphonuclear cell degranulation by tenidap sodium in patients with rheumatoid arthritis. Arthritis Rheum 1991; 34: 204-10.","journal-title":"Arthritis Rheum"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"480","DOI":"10.4049\/jimmunol.148.2.480","article-title":"Modification of proinflammatory cytokine production by the antirheumatic agents tenidap and naproxen. A possible correlate with clinical acute phase response","volume":"148","author":"D, Sipe J.; M, Bartle L.; D, Loose L.","year":"1992","unstructured":"Sipe J D, Bartle L M, Loose L D. Modification of proinflammatory cytokine production by the antirheumatic agents tenidap and naproxen. A possible correlate with clinical acute phase response. J Immunol 1992; 148: 480-4.","journal-title":"J Immunol"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724033429?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724033429?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.52.4.292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T06:22:12Z","timestamp":1738304532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724033429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,4]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,4]]}},"alternative-id":["S0003496724033429"],"URL":"https:\/\/doi.org\/10.1136\/ard.52.4.292","relation":{},"ISSN":["0003-4967"],"issn-type":[{"type":"print","value":"0003-4967"}],"subject":[],"published":{"date-parts":[[1993,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of tenidap on cartilage integrity in vitro.","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.52.4.292","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1993 \u00a9 THE AUTHORS. Published by Elsevier B.V. on behalf of European Alliance of Associations for Rheumatology, EULAR. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}