{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T02:41:50Z","timestamp":1772851310708,"version":"3.50.1"},"reference-count":4,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[1994,8,1]],"date-time":"1994-08-01T00:00:00Z","timestamp":775699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1994,8,1]],"date-time":"1994-08-01T00:00:00Z","timestamp":775699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[1994,8]]},"DOI":"10.1136\/ard.53.8.529","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T23:49:46Z","timestamp":1217288986000},"page":"529-534","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":130,"title":["Intra-articular injections of 750 kD hyaluronan in the treatment of osteoarthritis: a randomised single centre double-blind placebo-controlled trial of 91 patients demonstrating lack of efficacy."],"prefix":"10.1016","volume":"53","author":[{"given":"E.B.","family":"Henderson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.C.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Pegley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.R.","family":"Blake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"29","key":"ref_1","article-title":"I 1. 'Ihe properties and turnover of hyaluronan","volume-title":"Functions of the proteoglvcans. ('iba Fsuidatino Swipospaioum 124","volume":"9","author":"Laurent 1 C, Fraser","year":"1986","unstructured":"Laurent 1 C, Fraser I 1. 'Ihe properties and turnover of hyaluronan. In: Evered D, Whelan J, eds. Functions of the proteoglvcans. ('iba Fsuidatino Swipospaioum 124. Chichester: Wiley 1986: 9 29."},{"issue":"143 4","key":"ref_2","article-title":"linical studies of the intraarticular injection of Healon' (sodium hyaluronate) in the treatment of osteoarthritis of human knecs","volume-title":"I.it aisthitii a7ils \/lulalr(ti.sss, sol 11, Nes York: Grune and Stratton","volume":"1981","author":"Wciss C 13alazs E A. St. Onge R, Denliiger J LC","unstructured":"Wciss C 13alazs E A. St. Onge R, Denliiger J LC. linical studies of the intraarticular injection of Healon' (sodium hyaluronate) in the treatment of osteoarthritis of human knecs. In: Talbot J H, ed. ScInina rs I.it aisthitii a7ils \/lulalr(ti.sss, sol 11, Nes York: Grune and Stratton, 1981: 143 4."},{"issue":"98","key":"ref_3","article-title":"In: Helfet A J, cd","volume":"183","author":"Sololismon 1, Helfet A J. Osteoarthritis","year":"1982","unstructured":"Sololismon 1, Helfet A J. Osteoarthritis. In: Helfet A J, cd. l)i.st),ci\/ ft\/.h ks., 2nd e(d. IPhiladelphia: I.ippincott. 1982: 183 98."},{"issue":"87 91","key":"ref_4","article-title":"Comparison of an anti-inflammatory dose of ibuprofeni, and analgesic dose of ibuprofen, and acetaimiinoiphen in osteoarthritis of the knce..\\ ug! 7A1Ild","volume":"325","year":"1991","unstructured":"Bradley J L), Brandt K D, Katz B 13, Kalasinski L A, Ryan S I. Comparison of an anti-inflammatory dose of ibuprofeni, and analgesic dose of ibuprofen, and acetaimiinoiphen in osteoarthritis of the knce..\\ ug! 7A1Ild 1991;325:87 91."}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724404925?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724404925?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.53.8.529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T11:38:27Z","timestamp":1737545907000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724404925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,8]]},"references-count":4,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1994,8]]}},"alternative-id":["S0003496724404925"],"URL":"https:\/\/doi.org\/10.1136\/ard.53.8.529","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[1994,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intra-articular injections of 750 kD hyaluronan in the treatment of osteoarthritis: a randomised single centre double-blind placebo-controlled trial of 91 patients demonstrating lack of efficacy.","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.53.8.529","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1994 \u00a9 THE AUTHORS. Published by Elsevier B.V. on behalf of European Alliance of Associations for Rheumatology, EULAR. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}