{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:40:40Z","timestamp":1791492040172,"version":"4.3.4"},"reference-count":29,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2001,6,1]],"date-time":"2001-06-01T00:00:00Z","timestamp":991353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2001,6,1]],"date-time":"2001-06-01T00:00:00Z","timestamp":991353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2001,6]]},"DOI":"10.1136\/ard.60.6.627","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:45:32Z","timestamp":1027766732000},"page":"627-631","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":122,"title":["Raised levels of F2-isoprostanes and prostaglandin F2\u03b1 in different rheumatic diseases"],"prefix":"10.1016","volume":"60","author":[{"given":"S","family":"Basu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Whiteman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D L","family":"Mattey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Halliwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1136\/ard.60.6.627_bib1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1136\/ard.54.6.505","article-title":"Oxygen radicals, nitric oxide and human inflammatory joint disease.","volume":"54","author":"Halliwell","year":"1995","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.60.6.627_bib2","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1136\/ard.55.12.915","article-title":"Hydroxyl radical generation by rheumatoid blood and knee joint fluid.","volume":"55","author":"Kaur","year":"1996","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.60.6.627_bib3","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1042\/bj2860345","article-title":"Activation of neutrophil reactive-oxidant production by synovial fluid from patients with inflammatory joint disease.","volume":"286","author":"Robinson","year":"1992","journal-title":"Biochem J"},{"key":"10.1136\/ard.60.6.627_bib4","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1136\/ard.50.11.760","article-title":"Localisation of xanthine oxidase to synovial endothelium.","volume":"50","author":"Stevens","year":"1991","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.60.6.627_bib5","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0140-6736(89)91305-6","article-title":"Hypoxic-reperfusion injury in inflamed human joint.","volume":"334","author":"Blake","year":"1989","journal-title":"Lancet"},{"key":"10.1136\/ard.60.6.627_bib6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3109\/10715768809066917","article-title":"Breath pentane excretion as marker of disease activity in rheumatoid arthritis.","volume":"5","author":"Humad","year":"1988","journal-title":"Free Radic Res Commun"},{"key":"10.1136\/ard.60.6.627_bib7","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1042\/cs0660691","article-title":"Lipid peroxidation in rheumatoid arthritis: thiobarbituric-reactive material and catalytic iron salts in synovial fluid from rheumatoid arthritis.","volume":"66","author":"Rowley","year":"1984","journal-title":"Clin Sci"},{"key":"10.1136\/ard.60.6.627_bib8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0968-0004(90)90206-Q","article-title":"The measurement of free radical reactions in humans.","volume":"15","author":"Gutteridge","year":"1990","journal-title":"Trends Biochem Sci"},{"key":"10.1136\/ard.60.6.627_bib9","doi-asserted-by":"crossref","first-page":"9383","DOI":"10.1073\/pnas.87.23.9383","article-title":"A series of prostaglandine F2-like compounds are produced in vivo in humans by a noncyclooxygenase, free radical catalyzed mechanism.","volume":"87","author":"Morrow","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1136\/ard.60.6.627_bib10","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1172\/JCI116143","article-title":"Non-cyclooxygenase-derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids.","volume":"90","author":"Morrow","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1136\/ard.60.6.627_bib11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/01.CIR.94.1.19","article-title":"Modulation of oxidant stress in vivo in chronic cigarette smokers.","volume":"94","author":"Reilly","year":"1996","journal-title":"Circulation"},{"key":"10.1136\/ard.60.6.627_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-2952(95)02072-1","article-title":"The isoprostanes. Current knowledge and directions for future research.","volume":"51","author":"Morrow","year":"1996","journal-title":"Biochem Pharmacol"},{"key":"10.1136\/ard.60.6.627_bib13","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0014-5793(98)01290-3","article-title":"Oxidative injury and survival during endotoxemia.","volume":"438","author":"Basu","year":"1998","journal-title":"FEBS Lett"},{"key":"10.1136\/ard.60.6.627_bib14","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1006\/bbrc.1998.9956","article-title":"Oxidative injury induced cyclooxygenase activation in experimental hepatotoxicity.","volume":"254","author":"Basu","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1136\/ard.60.6.627_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-5793(00)01279-5","article-title":"Development of a novel biomarker of free radical damage in reperfusion injury after cardiac arrest.","volume":"470","author":"Basu","year":"2000","journal-title":"FEBS Lett"},{"key":"10.1136\/ard.60.6.627_bib16","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1172\/JCI5584","article-title":"Alcohol-induced generation of lipid peroxidation products in humans.","volume":"104","author":"Meagher","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1136\/ard.60.6.627_bib17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1034\/j.1399-6576.2000.440104.x","article-title":"Lipid peroxidation induced by an early inflammatory response in endotoxaemia.","volume":"44","author":"Basu","year":"2000","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1136\/ard.60.6.627_bib18","doi-asserted-by":"crossref","first-page":"16737","DOI":"10.1016\/S0021-9258(17)44821-6","article-title":"The indication and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.","volume":"265","author":"Fu","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1136\/ard.60.6.627_bib19","first-page":"41","article-title":"A better understanding of anti-inflammatory drugs based on isoforms of cyclooxygenase (COX-1 and COX-2).","volume":"23","author":"Vane","year":"1995","journal-title":"Adv Prostaglandin Thromboxane Leukot Res"},{"key":"10.1136\/ard.60.6.627_bib20","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1073\/pnas.88.7.2692","article-title":"Expression of mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.","volume":"88","author":"Xie","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1136\/ard.60.6.627_bib21","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0952-3278(98)90070-9","article-title":"Radioimmunoassay of 15-keto-dihydro-prostaglandin F2\u03b1: an index for inflammation via cyclooxygenase catalysed lipid peroxidation.","volume":"58","author":"Basu","year":"1998","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1136\/ard.60.6.627_bib22","series-title":"Natural antioxidants and anticarcinogens in nutrition, health and disease.","first-page":"260","article-title":"Radioimmunoassays of isoprostanes and prostaglandins as biomarkers of oxidative stress and inflammation.","author":"Basu","year":"1999"},{"key":"10.1136\/ard.60.6.627_bib23","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0952-3278(98)90042-4","article-title":"Radioimmunoassay of 8-iso-prostaglandin F2\u03b1: an index for oxidative injury via free radical catalysed lipid peroxidation.","volume":"58","author":"Basu","year":"1998","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1136\/ard.60.6.627_bib24","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/rheumatology\/38.6.529","article-title":"Oxidative stress in systemic lupus erythematosus and allied conditions with vascular involvement.","volume":"38","author":"Ames","year":"1999","journal-title":"Rheumatology"},{"key":"10.1136\/ard.60.6.627_bib25","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.60.6.627_bib26","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/art.1780390711","article-title":"Evidence of free radical-mediated injury (isoprostane overproduction) in scleroderma.","volume":"39","author":"Stein","year":"1996","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.60.6.627_bib27","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1136\/ard.51.11.1261","article-title":"Drug-derived radicals: mediators of the side effects of anti-inflammatory drugs?","volume":"51","author":"Halliwell","year":"1992","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.60.6.627_bib28","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/0006-2952(92)90131-2","article-title":"Oxidative damage to lipids and \u03b1-1-antiproteinase by phenylbutazone in the presence of haem proteins. Protection by ascorbic acid.","volume":"44","author":"Evans","year":"1992","journal-title":"Biochem Pharmacol"},{"key":"10.1136\/ard.60.6.627_bib29","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1042\/bj2450415","article-title":"Bleomycin-detectable iron in knee-joint synovial fluid from arthritic patients and its relationship to extracellular antioxidant activities of caeruplasmin.","volume":"245","author":"Gutteridge","year":"1987","journal-title":"Biochem J"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724442428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724442428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.60.6.627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T12:43:39Z","timestamp":1737549819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724442428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["S0003496724442428"],"URL":"https:\/\/doi.org\/10.1136\/ard.60.6.627","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2001,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Raised levels of F2-isoprostanes and prostaglandin F2\u03b1 in different rheumatic diseases","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.60.6.627","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2001 Annals of the Rheumatic Diseases. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}