{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T16:53:38Z","timestamp":1778086418419,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2002,2]]},"DOI":"10.1136\/ard.61.2.110","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:29:07Z","timestamp":1027765747000},"page":"110-114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["High titres of serum antinuclear antibodies, mostly directed against nucleolar antigens, are associated with the presence of coronary atherosclerosis"],"prefix":"10.1016","volume":"61","author":[{"given":"D J","family":"Grainger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H W L","family":"Bethell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1136\/ard.61.2.110_bib1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S1097-2765(00)80139-2","article-title":"Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice","volume":"2","author":"Gu","year":"1998","journal-title":"Mol Cell"},{"key":"10.1136\/ard.61.2.110_bib2","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/29788","article-title":"Decreased lesion formation in CCR2-\/- mice reveals a role for chemokines in the initiation of atherosclerosis","volume":"394","author":"Boring","year":"1998","journal-title":"Nature"},{"key":"10.1136\/ard.61.2.110_bib3","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1161\/01.CIR.97.20.2007","article-title":"C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction","volume":"97","author":"Ridker","year":"1998","journal-title":"Circulation"},{"key":"10.1136\/ard.61.2.110_bib4","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1161\/01.CIR.97.5.425","article-title":"Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease","volume":"97","author":"Ridker","year":"1998","journal-title":"Circulation"},{"key":"10.1136\/ard.61.2.110_bib5","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/00041433-199610000-00012","article-title":"Macrophages and atherosclerotic plaque stability","volume":"7","author":"Libby","year":"1996","journal-title":"Curr Opin Lipidol"},{"key":"10.1136\/ard.61.2.110_bib6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0002-9440(10)65540-X","article-title":"Macrophages in human atheroma contain PPARgamma: differentiation-dependent PPARgamma expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitro","volume":"153","author":"Marx","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1136\/ard.61.2.110_bib7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0009-8981(98)00013-8","article-title":"Autoantibodies to gangliosides in sera of atherosclerotic patients","volume":"272","author":"Golovanova","year":"1998","journal-title":"Clin Chim Acta"},{"key":"10.1136\/ard.61.2.110_bib8","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1053\/euhj.1997.0618","article-title":"Association between antibodies to heat shock protein 65 and coronary atherosclerosis. Possible mechanism of action of Helicobacter pylori and other bacterial infections in increasing cardiovascular risk","volume":"19","author":"Birnie","year":"1998","journal-title":"Eur Heart J"},{"key":"10.1136\/ard.61.2.110_bib9","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1177\/096120339700600704","article-title":"Accelerated atherosclerosis and coronary disease in SLE","volume":"6","author":"Farhey","year":"1997","journal-title":"Lupus"},{"key":"10.1136\/ard.61.2.110_bib10","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/BF02935315","article-title":"Emerging cross-regulatory roles of immunity and autoimmunity in atherosclerosis","volume":"15","author":"George","year":"1996","journal-title":"Immunol Res"},{"key":"10.1136\/ard.61.2.110_bib11","first-page":"596","article-title":"Atherosclerosis as an autoimmune condition","volume":"31","author":"Kleindienst","year":"1995","journal-title":"Isr J Med Sci"},{"key":"10.1136\/ard.61.2.110_bib12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0167-5699(95)80067-0","article-title":"Is atherosclerosis an immunologically mediated disease?","volume":"16","author":"Wick","year":"1995","journal-title":"Immunol Today"},{"key":"10.1136\/ard.61.2.110_bib13","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/clin.1994.1184","article-title":"Atherosclerosis and autoimmunity","volume":"73","author":"Lopes-Virella","year":"1994","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1136\/ard.61.2.110_bib14","first-page":"526","article-title":"Isolation and identification of autoimmune lipoprotein-antibody complex from blood serum of rabbits with experimental atherosclerosis","volume":"21","author":"Klimov","year":"1975","journal-title":"Vopr Med Khim"},{"key":"10.1136\/ard.61.2.110_bib15","doi-asserted-by":"crossref","unstructured":"Anonymous. Immunological start to atherosclerosis? [editorial]. Lancet 1975;i:208.","DOI":"10.1016\/S0140-6736(75)91372-0"},{"key":"10.1136\/ard.61.2.110_bib16","first-page":"110","article-title":"Effects of nutrition on disease and life span. I. Immune responses, cardiovascular pathology, and life span in MRL mice","volume":"117","author":"Mark","year":"1984","journal-title":"Am J Pathol"},{"key":"10.1136\/ard.61.2.110_bib17","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1073\/pnas.80.3.874","article-title":"Influence of diet on vascular lesions in autoimmune-prone B\/W mice","volume":"80","author":"Fernandes","year":"1983","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1136\/ard.61.2.110_bib18","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/28204","article-title":"Reduction of atherosclerosis in mice by inhibition of CD40 signalling","volume":"394","author":"Mach","year":"1998","journal-title":"Nature"},{"key":"10.1136\/ard.61.2.110_bib19","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1172\/JCI119892","article-title":"Immunoglobulin treatment reduces atherosclerosis in apo E knockout mice","volume":"102","author":"Nicoletti","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1136\/ard.61.2.110_bib20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0021-9150(93)90218-J","article-title":"Antibodies to cytoskeletal proteins in sera of patients with angiographically assessed coronary artery disease","volume":"98","author":"Nikkari","year":"1993","journal-title":"Atherosclerosis"},{"key":"10.1136\/ard.61.2.110_bib21","first-page":"32","article-title":"Cardiolipin antibodies in patients with myocardial infarction and unstable angina pectoris","volume":"32","author":"Nasonov","year":"1992","journal-title":"Kardiologiia"},{"key":"10.1136\/ard.61.2.110_bib22","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1177\/096120339600500522","article-title":"Antiphospholipid antibodies and atherosclerosis","volume":"5","author":"Vaarala","year":"1996","journal-title":"Lupus"},{"key":"10.1136\/ard.61.2.110_bib23","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1365-2249.1995.tb06652.x","article-title":"Autoantibodies against oxidized low density lipoproteins (oxLDL): characterization of antibody isotype, subclass, affinity and effect on the macrophage uptake of oxLDL","volume":"102","author":"Wu","year":"1995","journal-title":"Clin Exp Immunol"},{"key":"10.1136\/ard.61.2.110_bib24","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1161\/01.ATV.14.1.32","article-title":"Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL","volume":"14","author":"Yla-Herttuala","year":"1994","journal-title":"Arterioscler Thromb"},{"key":"10.1136\/ard.61.2.110_bib25","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0021-9150(90)90044-J","article-title":"Circulating IgA-Lp complexes in Watanabe heritable hyperlipidemic and cholesterol fed NZW rabbits","volume":"82","author":"Beaumont","year":"1990","journal-title":"Atherosclerosis"},{"key":"10.1136\/ard.61.2.110_bib26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0163-7258(96)00202-1","article-title":"Low-density lipoprotein and oxidised low-density lipoprotein: their role in the development of atherosclerosis","volume":"74","author":"Hamilton","year":"1997","journal-title":"Pharmacol Ther"},{"key":"10.1136\/ard.61.2.110_bib27","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/art.1780230602","article-title":"Diversity of antinuclear antibodies in progressive systemic sclerosis. Anti-centromere antibody and its relationship to CREST syndrome","volume":"23","author":"Tan","year":"1980","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.61.2.110_bib28","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0889-857X(21)00316-1","article-title":"Antinuclear antibodies in Sj\u00f6gren's syndrome","volume":"18","author":"Chan","year":"1992","journal-title":"Rheum Dis Clin North Am"},{"key":"10.1136\/ard.61.2.110_bib29","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0022-1759(98)00140-9","article-title":"Variability between methods to determine ANA, anti-dsDNA and anti-ENA autoantibodies: a collaborative study with the biomedical industry","volume":"219","author":"Bizzaro","year":"1998","journal-title":"J Immunol Methods"},{"key":"10.1136\/ard.61.2.110_bib30","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/clin.1998.4560","article-title":"New methods for detection of anti-nuclear antibodies","volume":"88","author":"Cook","year":"1998","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1136\/ard.61.2.110_bib31","series-title":"Autoantibodies to nuclear antigens (ANA): immunocytochemical specificities and significance in systemic rheumatic disease","author":"Nakamura","year":"1978"},{"key":"10.1136\/ard.61.2.110_bib32","first-page":"83","article-title":"Anti-nuclear, anti-mitochondrial, anti-smooth muscle and anti-parietal cell antibodies in the healthy Malaysian population","volume":"17","author":"Azizah","year":"1995","journal-title":"Malays J Pathol"},{"key":"10.1136\/ard.61.2.110_bib33","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/S0002-8703(98)70148-6","article-title":"Biochemical markers and cardiac troponin I release after radiofrequency catheter ablation: approach to size of necrosis","volume":"136","author":"Madrid","year":"1998","journal-title":"Am Heart J"},{"key":"10.1136\/ard.61.2.110_bib34","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1093\/clinchem\/44.11.2270","article-title":"Cardiac troponin I and minor cardiac damage: biochemical markers in a clinical model of myocardial lesions","volume":"44","author":"del Rey","year":"1998","journal-title":"Clin Chem"},{"key":"10.1136\/ard.61.2.110_bib35","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1053\/euhj.1998.1233","article-title":"Troponin T in patients with low grade or atypical angina. Identification of a high risk group for short- and long-term cardiovascular events","volume":"19","author":"Mockel","year":"1998","journal-title":"Eur Heart J"},{"key":"10.1136\/ard.61.2.110_bib36","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3109\/01485017808988344","article-title":"Immunological consequences of vasectomy: I. Prospective study through one-year postvasectomy","volume":"1","author":"Lucas","year":"1978","journal-title":"Arch Androl"},{"key":"10.1136\/ard.61.2.110_bib37","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF02909030","article-title":"Vasectomy (an experimental autoimmune disease state)","volume":"11","author":"Teuscher","year":"1981","journal-title":"Ric Clin Lab"},{"key":"10.1136\/ard.61.2.110_bib38","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1126\/science.96532","article-title":"Vasectomy increases the severity of diet-induced atherosclerosis in Macaca fascicularis","volume":"201","author":"Alexander NJ&Clarkson","year":"1978","journal-title":"Science"},{"key":"10.1136\/ard.61.2.110_bib39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1172\/JCI109645","article-title":"Long-term vasectomy: effects on the occurrence and extent of atherosclerosis in rhesus monkeys","volume":"65","author":"Clarkson","year":"1980","journal-title":"J Clin Invest"},{"key":"10.1136\/ard.61.2.110_bib40","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1161\/01.ATV.8.5.488","article-title":"Atherosclerosis of cynomolgus monkeys hyper- and hyporesponsive to dietary cholesterol. Lack of effect of vasectomy","volume":"8","author":"Clarkson","year":"1988","journal-title":"Arteriosclerosis"},{"key":"10.1136\/ard.61.2.110_bib41","first-page":"32","article-title":"Changing views on plasma risk factors for atherosclerosis","volume":"28","author":"Grainger","year":"1999","journal-title":"J Irish Coll Phys Surg"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724094603?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724094603?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.61.2.110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T23:41:51Z","timestamp":1737243711000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724094603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,2]]}},"alternative-id":["S0003496724094603"],"URL":"https:\/\/doi.org\/10.1136\/ard.61.2.110","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2002,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High titres of serum antinuclear antibodies, mostly directed against nucleolar antigens, are associated with the presence of coronary atherosclerosis","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.61.2.110","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2002 Copyright 2002 by Annals of the Rheumatic Diseases, Published by Elsevier Inc. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}