{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:27:57Z","timestamp":1792063677703,"version":"4.4.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2003,9]]},"DOI":"10.1136\/ard.62.9.870","type":"journal-article","created":{"date-parts":[[2003,8,15]],"date-time":"2003-08-15T17:59:16Z","timestamp":1060970356000},"page":"870-874","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":217,"title":["Clinical utility of the anti-CCP assay in patients with rheumatic diseases"],"prefix":"10.1016","volume":"62","author":[{"given":"D M","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P H","family":"Schur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1136\/ard.62.9.870_bib1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.62.9.870_bib2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/art.10092","article-title":"Treating rheumatoid arthritis early: a window of opportunity?","volume":"46","author":"O\u2019Dell","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.62.9.870_bib3","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/art.10135","article-title":"Delay to institution of therapy and induction of remission using single- drug or combination-disease-modifying antirheumatic drug therapy in early rheumatoid arthritis","volume":"46","author":"Mottonen","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.62.9.870_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3181\/00379727-68-16375","article-title":"Differential agglutination of normal and sensitized sheep erythrocytes by sera of patients with rheumatoid arthritis","volume":"68","author":"Rose","year":"1949","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1136\/ard.62.9.870_bib5","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/art.1780230611","article-title":"Rheumatoid factor detection by nephelometry","volume":"23","author":"Weinblatt","year":"1980","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.62.9.870_bib6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/art.10241","article-title":"Value of laboratory tests in early prediction of rheumatoid arthritis","volume":"47","author":"Saraux","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.62.9.870_bib7","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1136\/ard.61.6.505","article-title":"Comparative study of different enzyme immunoassays for measurement of IgM and IgA rheumatoid factors","volume":"61","author":"Bas","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.62.9.870_bib8","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1093\/clinchem\/47.6.1089","article-title":"Diagnostic accuracy of the anti-citrulline antibody assay for rheumatoid arthritis","volume":"47","author":"Bizzaro","year":"2001","journal-title":"Clin Chem"},{"key":"10.1136\/ard.62.9.870_bib9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/1529-0131(200001)43:1<155::AID-ANR20>3.0.CO;2-3","article-title":"The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide","volume":"43","author":"Schellekens","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.62.9.870_bib10","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0021-9681(67)90009-4","article-title":"Estimates of the prevalence of rheumatic diseases in the population of Tecumseh, Michigan, 1959\u20131960","volume":"20","author":"Mikkelsen","year":"1967","journal-title":"J Chronic Dis"},{"key":"10.1136\/ard.62.9.870_bib11","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.7326\/0003-4819-52-5-1059","article-title":"Incidence and significance of seropositive tests for rheumatoid factor in non-rheumatoid disease","volume":"52","author":"Bartfeld","year":"1960","journal-title":"Ann Intern Med"},{"key":"10.1136\/ard.62.9.870_bib12","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/0002-9343(66)90200-2","article-title":"Cryoglobulinemia\u2014a clinical and laboratory study","volume":"40","author":"Meltzer","year":"1966","journal-title":"Am J Med"},{"key":"10.1136\/ard.62.9.870_bib13","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/0002-9343(91)90190-9","article-title":"The rheumatoid factor: an analysis of clinical utility","volume":"91","author":"Shmerling","year":"1991","journal-title":"Am J Med"},{"key":"10.1136\/ard.62.9.870_bib14","series-title":"Textbook of rheumatology","first-page":"155","article-title":"Rheumatoid factor","author":"Carson","year":"1997"},{"key":"10.1136\/ard.62.9.870_bib15","series-title":"Arthritis and allied conditions","first-page":"1223","article-title":"Rheumatoid factor","author":"Bridges","year":"2001"},{"key":"10.1136\/ard.62.9.870_bib16","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1093\/rheumatology\/39.10.1082","article-title":"Association of rheumatoid factors and anti-filaggrin antibodies with severity of erosions in rheumatoid arthritis","volume":"39","author":"Bas","year":"2000","journal-title":"Rheumatology (Oxford)"},{"issue":"suppl 1","key":"10.1136\/ard.62.9.870_bib17","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/oxfordjournals.rheumatology.a031490","article-title":"Prognostic factors in early rheumatoid arthritis","volume":"39","author":"Scott","year":"2000","journal-title":"Rheumatology (Oxford)"},{"key":"10.1136\/ard.62.9.870_bib18","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/art.10117","article-title":"How to diagnose rheumatoid arthritis early: a prediction model for persistent (erosive) arthritis","volume":"46","author":"Visser","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.62.9.870_bib19","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1136\/bmj.313.7055.471","article-title":"A simple algorithm to predict the development of radiological erosions in patients with early rheumatoid arthritis: prospective cohort study","volume":"313","author":"Brennan","year":"1996","journal-title":"BMJ"},{"key":"10.1136\/ard.62.9.870_bib20","first-page":"1288","article-title":"Factors predicting outcome of rheumatoid arthritis: results of a followup study","volume":"20","author":"van Zeben","year":"1993","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.62.9.870_bib21","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1002\/1529-0131(200008)43:8<1831::AID-ANR19>3.0.CO;2-6","article-title":"The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritis","volume":"43","author":"Kroot","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.62.9.870_bib22","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/rheumatology\/41.7.809","article-title":"Diagnostic tests for rheumatoid arthritis: comparison of anti-cyclic citrullinated peptide antibodies, anti-keratin antibodies and IgM rheumatoid factors","volume":"41","author":"Bas","year":"2002","journal-title":"Rheumatology (Oxford)"},{"key":"10.1136\/ard.62.9.870_bib23","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1136\/bmj.2.6182.97","article-title":"Anti-keratin antibodies in rheumatoid arthritis","volume":"ii","author":"Young","year":"1979","journal-title":"BMJ"},{"key":"10.1136\/ard.62.9.870_bib24","first-page":"1027","article-title":"The Sa system: a novel antigen-antibody system specific for rheumatoid arthritis","volume":"21","author":"Despres","year":"1994","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.62.9.870_bib25","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1136\/ard.54.5.355","article-title":"Novel 68 kDa autoantigen detected by rheumatoid arthritis specific antibodies","volume":"54","author":"Blass","year":"1995","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.62.9.870_bib26","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.4049\/jimmunol.166.3.1492","article-title":"The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritis","volume":"166","author":"Corrigall","year":"2001","journal-title":"J Immunol"},{"key":"10.1136\/ard.62.9.870_bib27","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1002\/anr.1780321204","article-title":"Demonstration of a new antinuclear antibody (anti-RA33) that is highly specific for rheumatoid arthritis","volume":"32","author":"Hassfeld","year":"1989","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.62.9.870_bib28","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/90696","article-title":"Autoantibodies to GPI in rheumatoid arthritis: linkage between an animal model and human disease","volume":"2","author":"Schaller","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1136\/ard.62.9.870_bib29","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/ni0502-411b","article-title":"Few human autoimmune sera detect GPI","volume":"3","author":"Kassahn","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1136\/ard.62.9.870_bib30","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/ni0502-411a","article-title":"Autoantibodies to GPI and creatine kinase in RA","volume":"3","author":"Schubert","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1136\/ard.62.9.870_bib31","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1136\/ard.23.4.302","article-title":"A new serum factor in patients with rheumatoid arthritis. The antiperinuclear factor","volume":"23","author":"Nienhuis","year":"1964","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.62.9.870_bib32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/ar395","article-title":"Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value","volume":"4","author":"van Boekel","year":"2002","journal-title":"Arthritis Res"},{"key":"10.1136\/ard.62.9.870_bib33","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1172\/JCI1316","article-title":"Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies","volume":"101","author":"Schellekens","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1136\/ard.62.9.870_bib34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0001-2998(78)80014-2","article-title":"Basic principles of ROC analysis","volume":"8","author":"Metz","year":"1978","journal-title":"Semin Nucl Med"},{"key":"10.1136\/ard.62.9.870_bib35","series-title":"Nelson textbook of pediatrics","first-page":"2179","article-title":"Laboratory testing in infants and children","author":"Nicholson","year":"2000"},{"key":"10.1136\/ard.62.9.870_bib36","series-title":"Rheumatoid arthritis","first-page":"299","article-title":"The antiperinuclear factor and antikeratin antibodies in rheumatoid arthritis","author":"Hoet","year":"1992"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724088885?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724088885?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.62.9.870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T05:25:23Z","timestamp":1737437123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724088885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["S0003496724088885"],"URL":"https:\/\/doi.org\/10.1136\/ard.62.9.870","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2003,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical utility of the anti-CCP assay in patients with rheumatic diseases","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.62.9.870","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Copyright 2003 by Annals of the Rheumatic Diseases, Published by Elsevier Inc. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}