{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T02:12:11Z","timestamp":1763259131711,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:title\/>\n               <jats:p>Thyrotoxic periodic paralysis (TPP) is a rare metabolic disorder characterised by muscular weakness and paralysis in predisposed thyrotoxic patients. Although patients with TPP are almost uniformly men of Asian descent, cases have been reported in Caucasian and other ethnic populations. The rapid increase in ethnic diversity in Western and European nations has led to increase in TPP reports, where it was once considered exceedingly rare. Correcting the hypokalaemic and hyperthyroid state tends to reverse the paralysis. However, failure to recognise the condition may lead to delay in diagnosis and serious consequences including respiratory failure and death. We describe a young man who was diagnosed with hyperthyroidism who presented with acute paralysis. The clinical characteristics, pathophysiology and management of TTP are reviewed.<\/jats:p>","DOI":"10.1136\/bcr-02-2012-5931","type":"journal-article","created":{"date-parts":[[2012,8,27]],"date-time":"2012-08-27T14:55:22Z","timestamp":1346079322000},"page":"bcr0220125931","source":"Crossref","is-referenced-by-count":1,"title":["A young man presenting with paralysis after vigorous exercise"],"prefix":"10.1136","volume":"2012","author":[{"given":"Christopher","family":"Gubran","sequence":"first","affiliation":[{"name":"1Department of Gastroenterology, Walsall Manor Hospital, West Midlands, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajay","family":"Narain","sequence":"additional","affiliation":[{"name":"2Department of Cardiology, Birmingham Heartlands Hospital, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luqmaan","family":"Malik","sequence":"additional","affiliation":[{"name":"3Department of GP, Burton Hospital NHS trust, Staffordshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saad Aldeen","family":"Saeed","sequence":"additional","affiliation":[{"name":"4Department of Acute Medicine, Walsall Manor Hospital, Walsall, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,8,27]]},"reference":[{"key":"2025082803140946000_2012.aug27_1.bcr0220125931.1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-17-12-1454"},{"key":"2025082803140946000_2012.aug27_1.bcr0220125931.2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/00005792-199205000-00001","article-title":"Thyrotoxic periodic paralysis in the United States: report of 7 cases, a review of the literature","volume":"71","author":"Ober","year":"1992","journal-title":"Medicine"},{"key":"2025082803140946000_2012.aug27_1.bcr0220125931.3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0356"},{"key":"2025082803140946000_2012.aug27_1.bcr0220125931.4","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200405000-00025"},{"key":"2025082803140946000_2012.aug27_1.bcr0220125931.5","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.6.601"},{"key":"2025082803140946000_2012.aug27_1.bcr0220125931.6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020698"},{"key":"2025082803140946000_2012.aug27_1.bcr0220125931.7","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1515\/JPEM.2004.17.12.1679","article-title":"Thyrotoxic periodic paralysis associated with a mutation in the sodium channel gene SCN4A","volume":"17","author":"Lane","year":"2004","journal-title":"J Pediatr Endocrinol Metab"},{"key":"2025082803140946000_2012.aug27_1.bcr0220125931.8","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200309000-00004"},{"key":"2025082803140946000_2012.aug27_1.bcr0220125931.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2005.11.023"},{"key":"2025082803140946000_2012.aug27_1.bcr0220125931.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2005.09.002"},{"key":"2025082803140946000_2012.aug27_1.bcr0220125931.11","doi-asserted-by":"crossref","first-page":"427","DOI":"10.4158\/EP.12.4.427","article-title":"Thyrotoxic periodic paralysis in a Hispanic man after administration of prednisolone","volume":"12","author":"Liu","year":"2009","journal-title":"Endocr Pract"},{"key":"2025082803140946000_2012.aug27_1.bcr0220125931.12","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.46.0044"},{"key":"2025082803140946000_2012.aug27_1.bcr0220125931.13","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.45.1495"},{"key":"2025082803140946000_2012.aug27_1.bcr0220125931.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2004.09.016"},{"key":"2025082803140946000_2012.aug27_1.bcr0220125931.15","first-page":"584","article-title":"Thyrotoxic periodic paralysis: Effect of Propranolol","volume":"57","author":"Yeung","year":"1974","journal-title":"Ann Emerg Med"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-02-2012-5931","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:14:18Z","timestamp":1756376058000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-02-2012-5931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,27]]},"references-count":15,"alternative-id":["10.1136\/bcr-02-2012-5931"],"URL":"https:\/\/doi.org\/10.1136\/bcr-02-2012-5931","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2012,8,27]]}}}