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The lesions were removed for histological and immunohistochemical examination. Histopathological study of the destructed vertebral bodies in the two patients revealed the disruption or atrophy of bone trabeculae with infiltration of a large amount of B-lymphocytes and macrophages into the marrow cavities. Studies of its pathogenesis reveal that it is likely to be a B-lymphocyte-mediated local immune inflammatory reaction in the lumbar spine.<\/jats:p>","DOI":"10.1136\/bcr-03-2012-6121","type":"journal-article","created":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T10:06:37Z","timestamp":1338977197000},"page":"bcr0320126121","source":"Crossref","is-referenced-by-count":1,"title":["A kind of specific osteolytic destruction of the vertebral bodies"],"prefix":"10.1136","volume":"2012","author":[{"given":"Baogan","family":"Peng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Hei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,6,6]]},"reference":[{"key":"2025082801222130000_2012.jun05_1.bcr0320126121.1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1148\/radiology.172.1.2740507","article-title":"Avascular necrosis of the vertebral body: MR imaging","volume":"172","author":"Naul","year":"1989","journal-title":"Radiology"},{"key":"2025082801222130000_2012.jun05_1.bcr0320126121.2","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.2214\/ajr.167.6.8956592","article-title":"Vertebral fluid collection associated with vertebral collapse","volume":"167","author":"Dupuy","year":"1996","journal-title":"AJR"},{"key":"2025082801222130000_2012.jun05_1.bcr0320126121.3","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1148\/radiol.2213991129","article-title":"The intravertebral vacuum cleft sign","volume":"221","author":"Theodorou","year":"2001","journal-title":"Radiology"},{"key":"2025082801222130000_2012.jun05_1.bcr0320126121.4","doi-asserted-by":"crossref","unstructured":"Ma R Chow R Shen FH . 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