{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:46:01Z","timestamp":1790711161872,"version":"4.1.0"},"reference-count":12,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Holoprosencephaly is a rare spectrum of cerebral and facial malformations resulting from incomplete division of the embryonic forebrain (prosencephalon) into distinct lateral cerebral hemisphere. Holoprosencephaly spectrum in the fetus is often associated with other anomalies, particularly of the face and extremities. Here we present three different cases of patients with holoprosencephaly who failed to attain routine sonography during 11\u201320\u2005weeks owing to some unavoidable circumstances. Two of them were diagnosed during the third trimester and one in the late second trimester. Ultrasound findings of associated anomalies were confirmed after a clinical examination of the delivered fetuses.<\/jats:p>","DOI":"10.1136\/bcr-03-2012-6129","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T19:52:30Z","timestamp":1348602750000},"page":"bcr0320126129","source":"Crossref","is-referenced-by-count":9,"title":["Prenatal ultrasound diagnosis of holoprosencephaly and associated anomalies"],"prefix":"10.1136","volume":"2012","author":[{"given":"Hemang D","family":"Chaudhari","sequence":"first","affiliation":[{"name":"Department of Radiology, Smt. S.C.L. Municipal General Hospital, Smt. N.H.L. Municipal Medical College, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurudatt","family":"Thakkar","sequence":"additional","affiliation":[{"name":"Department of Radiology, Smt. S.C.L. Municipal General Hospital, Smt. N.H.L. Municipal Medical College, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parth","family":"Darji","sequence":"additional","affiliation":[{"name":"Department of Radiology, Smt. S.C.L. Municipal General Hospital, Smt. N.H.L. Municipal Medical College, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratik","family":"Khokhani","sequence":"additional","affiliation":[{"name":"Department of Radiology, Smt. S.C.L. Municipal General Hospital, Smt. N.H.L. Municipal Medical College, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2012,9,25]]},"reference":[{"key":"2025082803104976000_2012.sep25_2.bcr0320126129.1","unstructured":"Cohen HL Sivit CJ . Holoprosencephaly. In: Cohen HL Sivit CJ , eds. Fetal and pediatric ultrasound: a casebook approach. New York: McGraw-Hill, 2001:12\u201316."},{"key":"2025082803104976000_2012.sep25_2.bcr0320126129.2","unstructured":"Muenke M Beachy PA . Holoprosencephaly. In: Scriver CR Sly WS Childs B . eds. The metabolic and molecular bases of inherited disease. 8th edn. New York: McGraw-Hill Professional, 2001:6203\u201330."},{"key":"2025082803104976000_2012.sep25_2.bcr0320126129.3","unstructured":"Tegay DH Cohen HL Rosovsky M . Holoprosencephaly imaging, Medscape Reference. http:\/\/emedicine.medscape.com\/article\/409265-overview , 2008."},{"key":"2025082803104976000_2012.sep25_2.bcr0320126129.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(00)00084-8"},{"key":"2025082803104976000_2012.sep25_2.bcr0320126129.5","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1212\/01.WNL.0000037483.31989.B9","article-title":"Middle interhemispheric variant of holoprosencephaly: a distinct cliniconeuroradiologic subtype","volume":"59","author":"Lewis","year":"2002","journal-title":"Neurology"},{"key":"2025082803104976000_2012.sep25_2.bcr0320126129.6","unstructured":"Jones K . Smith's recognizable patterns of human malformations. 6th edn. Philadelphia, PA: Saunders, 2006:701\u20133."},{"key":"2025082803104976000_2012.sep25_2.bcr0320126129.7","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1542\/peds.34.2.256","article-title":"The face predicts the brain: diagnostic significance of median face anomalies for holoprosencephaly(arhinencephaly)","volume":"34","author":"DeMyer","year":"1964","journal-title":"Pediatrics"},{"key":"2025082803104976000_2012.sep25_2.bcr0320126129.8","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1212\/WNL.59.7.1058","article-title":"Neuroanatomy of holoprosencephaly as predictor of function: beyond the face predicting the brain","volume":"59","author":"Plawner","year":"2002","journal-title":"Neurology"},{"key":"2025082803104976000_2012.sep25_2.bcr0320126129.9","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20479"},{"key":"2025082803104976000_2012.sep25_2.bcr0320126129.10","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-8"},{"key":"2025082803104976000_2012.sep25_2.bcr0320126129.11","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.13.2479"},{"key":"2025082803104976000_2012.sep25_2.bcr0320126129.12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2235734100"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-03-2012-6129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:11:01Z","timestamp":1756375861000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-03-2012-6129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,25]]},"references-count":12,"alternative-id":["10.1136\/bcr-03-2012-6129"],"URL":"https:\/\/doi.org\/10.1136\/bcr-03-2012-6129","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,25]]}}}