{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:35:13Z","timestamp":1787240113415,"version":"build-2736575974"},"reference-count":12,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Lymphoproliferative disorders are often associated with autoimmune processes preceding or following the occurrence of a lymphoma. Here, we describe a patient with a history of recurrent diffuse large B-cell non-Hodgkin's lymphoma who suffered from an acute inflammatory neuropathy with specific monoclonal anti-GM2 IgM antibodies and associated IgM-\u03ba paraprotein. It was possible in this case to prove that both, anti-GM2 IgM antibodies and IgM-\u03ba paraprotein, share the same binding characteristic. In addition, the patient possibly suffered from an immune thrombocytopenia and an early-stage bullous pemphigoid with anti-BP-230 IgG antibodies. Intravenous immunoglobulin and plasmapheresis alleviated the acute neuropathy and thrombocytopenia, while the bullous pemphigoid has been aggravated. In summary, the simultaneous occurrence of multiple autoimmune processes was a sign of a dysfunctional immune system preceding the relapse of a B-cell non-Hodgkin's lymphoma.<\/jats:p>","DOI":"10.1136\/bcr-11-2011-5087","type":"journal-article","created":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T23:13:28Z","timestamp":1358810008000},"page":"bcr1120115087","source":"Crossref","is-referenced-by-count":7,"title":["Acute inflammatory neuropathy with monoclonal anti-GM2 IgM antibodies, IgM-\u03ba paraprotein and additional autoimmune processes in association with a diffuse large B-cell non-Hodgkin's lymphoma"],"prefix":"10.1136","volume":"2013","author":[{"given":"Annette","family":"Milnik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Roggenbuck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Conrad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudius","family":"Bartels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,1,21]]},"reference":[{"key":"2025042701402689000_2013.jan21_1.bcr1120115087.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.06.033"},{"key":"2025042701402689000_2013.jan21_1.bcr1120115087.2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1398.031"},{"key":"2025042701402689000_2013.jan21_1.bcr1120115087.3","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24141"},{"key":"2025042701402689000_2013.jan21_1.bcr1120115087.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5431-9"},{"key":"2025042701402689000_2013.jan21_1.bcr1120115087.5","doi-asserted-by":"publisher","DOI":"10.1016\/0009-3084(86)90046-0"},{"key":"2025042701402689000_2013.jan21_1.bcr1120115087.6","first-page":"401","article-title":"Ganglioside antigens expressed by human cancer cells","volume":"2","author":"Ritter","year":"1991","journal-title":"Semin Cancer Biol"},{"key":"2025042701402689000_2013.jan21_1.bcr1120115087.7","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(86)90068-4"},{"key":"2025042701402689000_2013.jan21_1.bcr1120115087.8","first-page":"636","article-title":"Ganglioside vaccines with emphasis on GM2","volume":"25","author":"Livingston","year":"1998","journal-title":"Semin Oncol"},{"key":"2025042701402689000_2013.jan21_1.bcr1120115087.9","first-page":"305","article-title":"Evaluation of ricin A chain-containing immunotoxins directed against glycolipid and glycoprotein on mouse lymphoma cells","volume":"48","author":"Usui","year":"1994","journal-title":"Acta medica Okayama"},{"key":"2025042701402689000_2013.jan21_1.bcr1120115087.10","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1136\/jnnp.66.3.376","article-title":"Antiganglioside antibodies in Guillain-Barr\u00e9 syndrome after a recent cytomegalovirus infection","volume":"66","author":"Khalili-Shirazi","year":"1999","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2025042701402689000_2013.jan21_1.bcr1120115087.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2004.07.020"},{"key":"2025042701402689000_2013.jan21_1.bcr1120115087.12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03380.x"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-11-2011-5087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T04:40:32Z","timestamp":1745728832000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-11-2011-5087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,21]]},"references-count":12,"alternative-id":["10.1136\/bcr-11-2011-5087"],"URL":"https:\/\/doi.org\/10.1136\/bcr-11-2011-5087","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,21]]}}}