{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:03:37Z","timestamp":1756339417832,"version":"3.44.0"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:title\/>\n               <jats:p>Malformations of cortical development (MCD) are important causes of chronic epilepsy. MCD encompass many varied disorders with diverse clinical manifestations. Schizencephaly, one of the MCD, is known to be complicated by various types of epilepsy, most of which are intractable. We treated a 28-year-old man with epilepsy, characterised by unprovoked generalised tonic\u2013clonic seizures accompanied by MCD. Brain MRI detected multiple malformations including septum pellucidum defect, partial corpus callosum defect, schizencephaly, right hippocampal atrophy, cerebellar atrophy and cerebellum atrophy. 99m Tc-ethylcysteinate dimer single photon emission CT showed decreased cerebral blood flow (CBF), and the morphology of CBF defects overlapped with the anomalous findings on MRI. The clinical outcome of the patient was good despite his severe brain malformations. Although the reason of this discrepancy is unclear, the outcomes of social function and epileptic seizures may be relatively good despite severe MCD in some patients.<\/jats:p>","DOI":"10.1136\/bcr-11-2011-5219","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T10:43:35Z","timestamp":1340880215000},"page":"bcr1120115219","source":"Crossref","is-referenced-by-count":0,"title":["Malformations of cortical development with good clinical outcome: a case report and review of literature"],"prefix":"10.1136","volume":"2012","author":[{"given":"Maya","family":"Yanase","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanobu","family":"Kaido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maki","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,6,28]]},"reference":[{"key":"2025082702502776000_2012.jun28_1.bcr1120115219.1","unstructured":"Ishikawa I Takahashi S . Study of \u2018Appropriate Education According to Ability\u2019 Theory by Harutaro Suzuki in the Prewar and Special Educational Considerations. Bulletin of Tokyo Gakugei University, Educational Sciences, Vol. 58 2007."},{"key":"2025082702502776000_2012.jun28_1.bcr1120115219.2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2208"},{"key":"2025082702502776000_2012.jun28_1.bcr1120115219.3","first-page":"398","article-title":"A study of major congenital defects in Japanese infants","volume":"10","author":"Neel","year":"1958","journal-title":"Am J Hum Genet"},{"key":"2025082702502776000_2012.jun28_1.bcr1120115219.4","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9069"},{"key":"2025082702502776000_2012.jun28_1.bcr1120115219.5","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-194607000-00001"},{"key":"2025082702502776000_2012.jun28_1.bcr1120115219.6","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-194604000-00003"},{"key":"2025082702502776000_2012.jun28_1.bcr1120115219.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.12.004"},{"key":"2025082702502776000_2012.jun28_1.bcr1120115219.8","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000115335.53381.2D"},{"key":"2025082702502776000_2012.jun28_1.bcr1120115219.9","doi-asserted-by":"publisher","DOI":"10.1038\/ng0196-94"},{"key":"2025082702502776000_2012.jun28_1.bcr1120115219.10","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1212\/WNL.48.5.1427","article-title":"Schizencephaly: correlations of clinical and radiologic features","volume":"48","author":"Packard","year":"1997","journal-title":"Neurology"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-11-2011-5219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:50:40Z","timestamp":1756288240000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-11-2011-5219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,28]]},"references-count":10,"alternative-id":["10.1136\/bcr-11-2011-5219"],"URL":"https:\/\/doi.org\/10.1136\/bcr-11-2011-5219","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2012,6,28]]}}}