{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T16:04:59Z","timestamp":1749917099972,"version":"3.40.4"},"reference-count":21,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:title\/><jats:p>Intracranial germ cell tumours (GCTs) are a rare and diverse group of tumours. Histology determines the type of treatment, natural history and prognosis. Germinoma GCTs account for the majority and are very radiosensitive. Conversely, non-germinoma GCTs (NGGCTs) are heterogeneous, relatively radioresistant and have a high risk of relapse despite multimodality therapy. Treatment of recurrence in these patients remains a therapeutic challenge. In this report we review the current literature for treatment of recurrent NGGCTs and present a case of recurrent NGGCT who relapsed despite autologous stem cell transplant (ASCT). The patient was successfully cured using multimodality therapy, consisting of repeat ASCT, intensity modulated radiation therapy and stereotactic radiosurgery.<\/jats:p>","DOI":"10.1136\/bcr-2012-006298","type":"journal-article","created":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T21:43:51Z","timestamp":1342734231000},"page":"bcr2012006298","source":"Crossref","is-referenced-by-count":4,"title":["Successful salvage using combined radiation and ABMT for patients with recurrent CNS NGGCT following failed initial transplant"],"prefix":"10.1136","volume":"2012","author":[{"given":"Kyle","family":"Malone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Croke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin","family":"Malone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shawn","family":"Malone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,7,19]]},"reference":[{"key":"2025042702422792000_2012.jul19_1.bcr2012006298.1","first-page":"233","article-title":"Primary intracranial germ cell tumors","volume":"2","author":"Bloom","year":"1983","journal-title":"Clin Oncol"},{"key":"2025042702422792000_2012.jul19_1.bcr2012006298.2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3171\/jns.1985.63.2.0155","article-title":"Intracranial germ-cell tumors: natural history and pathogenesis","volume":"63","author":"Jennings","year":"1985","journal-title":"J Neurosurg"},{"key":"2025042702422792000_2012.jul19_1.bcr2012006298.3","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2008-0037"},{"key":"2025042702422792000_2012.jul19_1.bcr2012006298.4","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1200\/JCO.1999.17.8.2585","article-title":"Radiation therapy for intracranial germinoma: results of the German cooperative prospective trials MAKEI 83\/86\/89","volume":"17","author":"Bamberg","year":"1999","journal-title":"J Clin Oncol"},{"key":"2025042702422792000_2012.jul19_1.bcr2012006298.5","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3171\/jns.1997.86.3.0446","article-title":"Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verified cases","volume":"86","author":"Matsutani","year":"1997","journal-title":"J Neurosurg"},{"key":"2025042702422792000_2012.jul19_1.bcr2012006298.6","unstructured":"Calaminus G Garre M . 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High dose etoposide and thiotepa for refractory and recurrent malignant intracranial germ cell tumors (CNS-GCT)","volume":"2","author":"Bouffet","year":"2000","journal-title":"Neurooncol"},{"key":"2025042702422792000_2012.jul19_1.bcr2012006298.21","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006395719917"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2012-006298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T09:42:34Z","timestamp":1745746954000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2012-006298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,19]]},"references-count":21,"alternative-id":["10.1136\/bcr-2012-006298"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2012-006298","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2012,7,19]]}}}