{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:33:46Z","timestamp":1788305626126,"version":"build-2803163510"},"reference-count":5,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:title\/>\n               <jats:p>Cushing syndrome (CS) in children is a rare disorder that is most frequently caused by an adrenal tumour or a pituitary corticotrophin-secreting adenoma. The management is challenging and requires an individualised approach and multidisciplinary care. We present the case of a 23-month-old female child with a history of excessive weight gain, growth failure, hirsutism, acne and behavioural difficulties. Investigations revealed elevated serum midnight cortisol and 24\u2005h urinary free cortisol. Overnight dexamethasone suppression testing showed no suppression of cortisol levels. Abdominal imaging revealed a right-sided suprarenal mass. She underwent right adrenalectomy and the histology showed an adrenal cortical carcinoma. There was clinical improvement with catch-up growth and weight normalisation. Despite being rare in clinical practice, in a child with weight gain, hirsuitism and growth failure the diagnosis must be considered. The overall prognosis of CS in childhood is good, but challenges remain to ensure normal growth and body composition.<\/jats:p>","DOI":"10.1136\/bcr-2012-006685","type":"journal-article","created":{"date-parts":[[2012,8,27]],"date-time":"2012-08-27T14:55:22Z","timestamp":1346079322000},"page":"bcr2012006685","source":"Crossref","is-referenced-by-count":4,"title":["Cushing syndrome associated with an adrenal tumour"],"prefix":"10.1136","volume":"2012","author":[{"given":"Helena","family":"Vieira","sequence":"first","affiliation":[{"name":"1Paediatric Department, Hospital de S\u00e3o Francisco Xavier, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Brain","sequence":"additional","affiliation":[{"name":"2Endocrinology Department, Great Ormond Street Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2012,8,27]]},"reference":[{"key":"2025082802172774000_2012.aug27_1.bcr2012006685.1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000329173","article-title":"Childhood Cushing disease: a challenge in diagnosis and management","volume":"76","author":"Shah","year":"2011","journal-title":"Horm Res Paediatr"},{"key":"2025082802172774000_2012.aug27_1.bcr2012006685.2","unstructured":"Stewart P . The adrenal cortex. In: Kronenberg H Melmed S Larsen P . eds. Williams Textbook of Endocrinology. 11st edn. Philadelphia: Saunders Elsevier, 2008: 460\u20137."},{"key":"2025082802172774000_2012.aug27_1.bcr2012006685.3","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e328305082f"},{"key":"2025082802172774000_2012.aug27_1.bcr2012006685.4","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1542\/peds.2006-2402","article-title":"Diagnostic tests for children who Are referred for the investigation of Cushing syndrome","volume":"120","author":"Batista","year":"2007","journal-title":"Pediatrics"},{"key":"2025082802172774000_2012.aug27_1.bcr2012006685.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.12.022"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2012-006685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:17:34Z","timestamp":1756372654000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2012-006685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,27]]},"references-count":5,"alternative-id":["10.1136\/bcr-2012-006685"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2012-006685","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,27]]}}}