{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:36:46Z","timestamp":1788961006155,"version":"build-2803163510"},"reference-count":40,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Tuberculosis is a universal mimicker and thus could be a differential diagnosis of any osteolytic lesion. Bone biopsy is crucial in these cases for culture and histological proof of tuberculous infection. This is a case report of two paediatric patients with unusual presentations of tuberculosis. One patient presented with knee pain and had imaged findings of an osteolytic lesion at the epiphysis. Interval scan showed spread of the lesion through the physis to the metaphyseal region. The second patient presented with hip pain and an osteolytic lesion of the acetabulum. He was subsequently found to have involvement of the brain and spine as well. Both patients were diagnosed with tuberculosis by bone biopsy for culture and pathological examination. They were treated successfully with antituberculous medications without chronic sequelae. These two patients showed that early recognition and prompt treatment are critical for management of tuberculosis to avoid chronic sequelae.<\/jats:p>","DOI":"10.1136\/bcr-2012-006714","type":"journal-article","created":{"date-parts":[[2012,10,19]],"date-time":"2012-10-19T18:57:43Z","timestamp":1350673063000},"page":"bcr2012006714","source":"Crossref","is-referenced-by-count":5,"title":["Unusual presentations of osteoarticular tuberculosis in two paediatric patients"],"prefix":"10.1136","volume":"2012","author":[{"given":"Jason Pui Yin","family":"Cheung","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Traumatology, Queen Mary Hospital, Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth Wai Yip","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, Queen Mary Hospital, Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying Lee","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, Queen Mary Hospital, Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony Wai Hung","family":"Shek","sequence":"additional","affiliation":[{"name":"Department of Pathology, Queen Mary Hospital, Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2012,10,19]]},"reference":[{"key":"2025082707410834000_2012.oct19_1.bcr2012006714.1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1136\/bmj.314.7085.919f","article-title":"Tuberculosis levelling off worldwide","volume":"314","author":"Westall","year":"1997","journal-title":"BMJ"},{"key":"2025082707410834000_2012.oct19_1.bcr2012006714.2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2003.00671.x"},{"key":"2025082707410834000_2012.oct19_1.bcr2012006714.3","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1111\/j.1469-0691.2009.03082.x","article-title":"Osteoarticular tuberculosis in Tehran, Iran: a 2-year study","volume":"16","author":"Hadadi","year":"2010","journal-title":"Clin Microbiol Infect"},{"key":"2025082707410834000_2012.oct19_1.bcr2012006714.4","doi-asserted-by":"publisher","DOI":"10.3944\/AOTT.2008.214"},{"key":"2025082707410834000_2012.oct19_1.bcr2012006714.5","first-page":"187","article-title":"Tuberculosis of peripheral joints: an often missed diagnosis","volume":"13","author":"Evanchick","year":"1986","journal-title":"J Rheumatol"},{"key":"2025082707410834000_2012.oct19_1.bcr2012006714.6","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-5-512"},{"key":"2025082707410834000_2012.oct19_1.bcr2012006714.7","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.D.02404"},{"key":"2025082707410834000_2012.oct19_1.bcr2012006714.8","doi-asserted-by":"publisher","DOI":"10.1097\/00004694-200303000-00017"},{"key":"2025082707410834000_2012.oct19_1.bcr2012006714.9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/01241398-200205000-00012","article-title":"Primary subacute epiphyseal osteomyelitis: role of conservative treatment","volume":"22","author":"Ezra","year":"2002","journal-title":"J Pediatr Orthop"},{"key":"2025082707410834000_2012.oct19_1.bcr2012006714.10","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/61028225"},{"key":"2025082707410834000_2012.oct19_1.bcr2012006714.11","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/01241398-199603000-00017","article-title":"Subacute hematogenous osteomyelitis: are biopsy and surgery always indicated?","volume":"16","author":"Hamdy","year":"1996","journal-title":"J Pediatr Orthop"},{"key":"2025082707410834000_2012.oct19_1.bcr2012006714.12","doi-asserted-by":"crossref","unstructured":"Kandel SN Mankin HJ . 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