{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:17:11Z","timestamp":1759990631974,"version":"3.40.4"},"reference-count":15,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Subacute sclerosing panencephalitis (SSPE) is a slowly progressing inflammatory and degenerative disorder of the brain caused by a mutant measles virus. The diagnosis of SSPE is based on characteristic clinical and EEG findings (periodic complexes) and demonstration of elevated antibody titres against measles in cerebrospinal fluid. SSPE can have atypical clinical features at the onset. The authors here report a case of a 3-year-old child who presented with vision loss followed 15\u2005months later by quadriparesis with bladder involvement. These clinical features resembled that of neuromyelitis optica. However, as the disease progressed, appearance of myoclonic jerks, periodic discharges on EEG and positive cerebrospinal fluid serology for measles led to the final diagnosis of SSPE.<\/jats:p>","DOI":"10.1136\/bcr-2012-006764","type":"journal-article","created":{"date-parts":[[2012,12,15]],"date-time":"2012-12-15T08:08:53Z","timestamp":1355558933000},"page":"bcr2012006764","source":"Crossref","is-referenced-by-count":3,"title":["Subacute sclerosing panencephalitis presenting as neuromyelitis optica"],"prefix":"10.1136","volume":"2012","author":[{"given":"Tushar Premraj","family":"Raut","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maneesh Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravindra Kumar","family":"Garg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pravin Umakant","family":"Naphade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,12,14]]},"reference":[{"key":"2025042707543199000_2012.dec14_1.bcr2012006764.1","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.78.916.63"},{"key":"2025042707543199000_2012.dec14_1.bcr2012006764.2","first-page":"73","article-title":"A study of SSPE: early clinical features","volume":"2","author":"Khadikar","year":"2004","journal-title":"J Pediatr Neurol"},{"key":"2025042707543199000_2012.dec14_1.bcr2012006764.3","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0733-8619(18)31062-4","article-title":"Subacute sclerosing panencephalitis: current status","volume":"3","author":"Dyken","year":"1985","journal-title":"Neurol Clin"},{"key":"2025042707543199000_2012.dec14_1.bcr2012006764.4","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.5.1107"},{"key":"2025042707543199000_2012.dec14_1.bcr2012006764.5","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410340211"},{"key":"2025042707543199000_2012.dec14_1.bcr2012006764.6","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.60.4.382"},{"key":"2025042707543199000_2012.dec14_1.bcr2012006764.7","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000216139.44259.74"},{"key":"2025042707543199000_2012.dec14_1.bcr2012006764.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03066.x"},{"key":"2025042707543199000_2012.dec14_1.bcr2012006764.9","first-page":"255","article-title":"Changes in the fundus in subacute sclerosing panencephalitis","volume":"15","author":"Cochereau-Massin","year":"1992","journal-title":"J Fr Ophthalmol"},{"key":"2025042707543199000_2012.dec14_1.bcr2012006764.10","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.57.10.780"},{"key":"2025042707543199000_2012.dec14_1.bcr2012006764.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(96)00261-4"},{"key":"2025042707543199000_2012.dec14_1.bcr2012006764.12","doi-asserted-by":"publisher","DOI":"10.1007\/BF02763061"},{"key":"2025042707543199000_2012.dec14_1.bcr2012006764.13","doi-asserted-by":"publisher","DOI":"10.1159\/000087721"},{"key":"2025042707543199000_2012.dec14_1.bcr2012006764.14","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/00005072-199604000-00010","article-title":"The significance of measles virus antigen and genome distribution in the CNS in SSPE for mechanisms of viral spread and demyelination","volume":"55","author":"Allen","year":"1996","journal-title":"J Neuropathol Exp Neurol"},{"key":"2025042707543199000_2012.dec14_1.bcr2012006764.15","first-page":"202","article-title":"Cervical spinal cord signal changes in a case of adult-onset subacute sclerosing panenchephalitis","volume":"20","author":"Sharma","year":"2010","journal-title":"Neuroradiology"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2012-006764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T14:54:38Z","timestamp":1745765678000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2012-006764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,14]]},"references-count":15,"alternative-id":["10.1136\/bcr-2012-006764"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2012-006764","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2012,12,14]]}}}