{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:50:07Z","timestamp":1774533007986,"version":"3.50.1"},"reference-count":4,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Premature ovarian failure in a well adolescent is a rare event. Its occurrence raises important questions about causation, which may signal other systemic concerns. This patient presented with amenorrhoea after identifying a change from her regular cycle to irregular and scant periods following vaccinations against human papillomavirus. She declined the oral contraceptives initially prescribed for amenorrhoea. The diagnostic tasks were to determine the reason for her secondary amenorrhoea and then to investigate for possible causes of the premature ovarian failure identified. Although the cause is unknown in 90% of cases, the remaining chief identifiable causes of this condition were excluded. Premature ovarian failure was then notified as a possible adverse event following this vaccination. The young woman was counselled regarding preservation of bone density, reproductive implications and relevant follow-up. This event could hold potential implications for population health and prompts further inquiry.<\/jats:p>","DOI":"10.1136\/bcr-2012-006879","type":"journal-article","created":{"date-parts":[[2012,10,3]],"date-time":"2012-10-03T07:48:55Z","timestamp":1349250535000},"page":"bcr2012006879","source":"Crossref","is-referenced-by-count":38,"title":["Premature ovarian failure 3\u2005years after menarche in a 16-year-old girl following human papillomavirus vaccination"],"prefix":"10.1136","volume":"2012","author":[{"given":"Deirdre Therese","family":"Little","sequence":"first","affiliation":[{"name":"1Department of General Practice, North Bellingen Medical Services, Bellingen, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harvey Rodrick Grenville","family":"Ward","sequence":"additional","affiliation":[{"name":"2Department of Obstetrics and Gynaecology, The University of New South Wales Rural Medical School in Coffs Harbour, Coffs Harbour, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,10,3]]},"reference":[{"key":"2025082804545958000_2012.sep26_1.bcr2012006879.1","first-page":"604","article-title":"Incidence of premature ovarian failure","volume":"67","author":"Coulam","year":"1986","journal-title":"Obstet Gynecol"},{"key":"2025082804545958000_2012.sep26_1.bcr2012006879.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0808697"},{"key":"2025082804545958000_2012.sep26_1.bcr2012006879.3","unstructured":"Islam R Cartwright R . Socioeconomic Class and Smoking Linked to Premature Menopause. Presented to European Society of Human Reproduction and Embryology Conference Stockholm 6 July 2011."},{"key":"2025082804545958000_2012.sep26_1.bcr2012006879.4","doi-asserted-by":"publisher","DOI":"10.1002\/bdrb.20174"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2012-006879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:55:09Z","timestamp":1756382109000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2012-006879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,3]]},"references-count":4,"alternative-id":["10.1136\/bcr-2012-006879"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2012-006879","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,3]]}}}