{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:27:11Z","timestamp":1791412031879,"version":"4.3.3"},"reference-count":16,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>The treatment of complex fistulae-in-ano is challenging and often includes a number of operations due to high rates of recurrence. We report the successful treatment of three consecutive patients with long-standing cryptoglandular fistula-in-ano with a novel combination of mucosal advancement flap and adipose-tissue derived regenerative cells (ADRCs) from the stromal vascular fraction (SVF) obtained from a simple lipoaspiration procedure, using Celution technology. There was no operative morbidity; one patient who had a colostomy for faecal diversion has since undergone restoration of bowel continuity. All thee fistulae remain healed at 2\u20133-year follow-up. Lipofilling of cryptoglandular fistulae-in-ano with ADRC-enhanced lipofilling appears feasible and safe, and may add to the range of procedures that can be used to treat this difficult problem.<\/jats:p>","DOI":"10.1136\/bcr-2012-006988","type":"journal-article","created":{"date-parts":[[2012,11,9]],"date-time":"2012-11-09T11:44:01Z","timestamp":1352461441000},"page":"bcr2012006988","source":"Crossref","is-referenced-by-count":13,"title":["Autologous adipose-tissue derived regenerative cells for the treatment of complex cryptoglandular fistula-in-ano: a report of three cases"],"prefix":"10.1136","volume":"2012","author":[{"given":"David W","family":"Borowski","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery, University Hospital North Tees, Stockton on Tees, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talvinder S","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, University Hospital North Tees, Stockton on Tees, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, University Hospital North Tees, Stockton on Tees, UK"},{"name":"Department of Surgery, University Hospital of North Tees, Stockton on Tees, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pudhupalayam","family":"Bhaskar","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital of North Tees, Stockton on Tees, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2012,11,9]]},"reference":[{"key":"2025082804553636000_2012.nov07_1.bcr2012006988.1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/bjs.1800630102","article-title":"A classification of fistula-in-ano","volume":"63","author":"Parks","year":"1976","journal-title":"Br J Surg"},{"key":"2025082804553636000_2012.nov07_1.bcr2012006988.2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02054434"},{"key":"2025082804553636000_2012.nov07_1.bcr2012006988.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(99)00180-4"},{"key":"2025082804553636000_2012.nov07_1.bcr2012006988.4","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-009-0522-2"},{"key":"2025082804553636000_2012.nov07_1.bcr2012006988.5","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-011-0769-2"},{"key":"2025082804553636000_2012.nov07_1.bcr2012006988.6","doi-asserted-by":"publisher","DOI":"10.1007\/BF02050009"},{"key":"2025082804553636000_2012.nov07_1.bcr2012006988.7","first-page":"17","article-title":"The surgisis AFP anal fistula plug: report of a consensus conference","volume":"10","author":"Corman","year":"2007","journal-title":"Colorectal Dis"},{"key":"2025082804553636000_2012.nov07_1.bcr2012006988.8","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-008-0559-0"},{"key":"2025082804553636000_2012.nov07_1.bcr2012006988.9","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-011-1350-1"},{"key":"2025082804553636000_2012.nov07_1.bcr2012006988.10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1990","journal-title":"Science"},{"key":"2025082804553636000_2012.nov07_1.bcr2012006988.11","doi-asserted-by":"publisher","DOI":"10.1089\/107632701300062859"},{"key":"2025082804553636000_2012.nov07_1.bcr2012006988.12","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.54.132"},{"key":"2025082804553636000_2012.nov07_1.bcr2012006988.13","doi-asserted-by":"publisher","DOI":"10.1080\/14653240801982979"},{"key":"2025082804553636000_2012.nov07_1.bcr2012006988.14","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0052-6"},{"key":"2025082804553636000_2012.nov07_1.bcr2012006988.15","unstructured":"National Institute for Clinical Excellence (NICE). Breast reconstruction using lipomodelling after breast cancer treatment\u2014IP 417. 2012."},{"key":"2025082804553636000_2012.nov07_1.bcr2012006988.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2012.02.178"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2012-006988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:55:47Z","timestamp":1756382147000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2012-006988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,9]]},"references-count":16,"alternative-id":["10.1136\/bcr-2012-006988"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2012-006988","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,9]]}}}