{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:25:11Z","timestamp":1760984711209,"version":"3.40.4"},"reference-count":19,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Subacute sclerosing panencephalitis (SSPE) is a slowly progressive inflammatory disease of the central nervous system caused by a persistent measles virus usually affecting the childhood and adolescent age group. Clinical features at onset are very subtle and non-specific. Certain atypical features can occur at onset or during the course of illness which can be misleading. Neuroimaging features often are non-specific. Features like myoclonic jerks, cognitive decline and typical EEG findings lead to a strong suspicion of SSPE. Here, we describe the stagewise progression of a case of SSPE in a 14-year-old girl who had myoclonic jerks and cognitive decline at onset. During the course of disease, the patient developed cortical vision loss, atypical extrapyramidal features like segmental and hemifacial dystonia ultimately leading to a bedbound vegetative state. EEG showed typical periodic discharges along with positive cerebrospinal fluid serology for measles.<\/jats:p>","DOI":"10.1136\/bcr-2012-007052","type":"journal-article","created":{"date-parts":[[2012,12,24]],"date-time":"2012-12-24T09:28:33Z","timestamp":1356341313000},"page":"bcr2012007052","source":"Crossref","is-referenced-by-count":4,"title":["Evolution of certain typical and atypical features in a case of subacute sclerosing panencephalitis"],"prefix":"10.1136","volume":"2012","author":[{"given":"Tushar Premraj","family":"Raut","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maneesh Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravindra Kumar","family":"Garg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dheeraj","family":"Rai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,12,24]]},"reference":[{"key":"2025042708001749000_2012.dec23_1.bcr2012007052.1","first-page":"337","article-title":"Subacute sclerosing panencephalitis","volume":"35","author":"Garg","year":"1998","journal-title":"Indian Pediatr"},{"key":"2025042708001749000_2012.dec23_1.bcr2012007052.2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1017\/S0950268800054637","article-title":"High incidence of subacute sclerosing panencephalitis in South India","volume":"104","author":"Saha","year":"1990","journal-title":"Epidemiol Infect"},{"key":"2025042708001749000_2012.dec23_1.bcr2012007052.3","first-page":"454","article-title":"Sur uncas d'encephalite subaiguea inclusions. Etude anatomoclinique et ultra structurale","volume":"113","author":"Bouteille","year":"1965","journal-title":"Rev Neurol (Paris)"},{"key":"2025042708001749000_2012.dec23_1.bcr2012007052.4","doi-asserted-by":"publisher","DOI":"10.1038\/221974a0"},{"key":"2025042708001749000_2012.dec23_1.bcr2012007052.5","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.78.916.63"},{"key":"2025042708001749000_2012.dec23_1.bcr2012007052.6","doi-asserted-by":"publisher","DOI":"10.1177\/088307380001500411"},{"key":"2025042708001749000_2012.dec23_1.bcr2012007052.7","first-page":"117","article-title":"Parkinsonian presentation of SSPE: report of two cases","volume":"13","author":"Misra","year":"2008","journal-title":"Neurol Asia"},{"key":"2025042708001749000_2012.dec23_1.bcr2012007052.8","first-page":"304","article-title":"Subacute sclerosing panencephalitis: CT and MR imaging in a rapidly progressive case","volume":"47","author":"Alexander","year":"1999","journal-title":"Neurol India"},{"key":"2025042708001749000_2012.dec23_1.bcr2012007052.9","doi-asserted-by":"crossref","unstructured":"Bosco D Plastino M Marcello M G . \u00a0Antonietta Fava Operative Unit of Neurology, S. Giovanni di Dio Hospital, Crotone, Italy. Acute hemifacial dystonia possibly induced by clebopride. Clin neuropharmacol 32:107\u20138.","DOI":"10.1097\/WNF.0b013e31817ec335"},{"key":"2025042708001749000_2012.dec23_1.bcr2012007052.10","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1212\/WNL.34.7.962","article-title":"Lesions of the putamen and dystonia, CT and MR imaging","volume":"34","author":"Burton","year":"1984","journal-title":"Neurology"},{"key":"2025042708001749000_2012.dec23_1.bcr2012007052.11","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.4.859"},{"key":"2025042708001749000_2012.dec23_1.bcr2012007052.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00177-X"},{"key":"2025042708001749000_2012.dec23_1.bcr2012007052.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80829-X"},{"key":"2025042708001749000_2012.dec23_1.bcr2012007052.14","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/mds.870120313","article-title":"Adult-onset subacute sclerosing panencephalitis: case reports and review of literature","volume":"10","author":"Singer","year":"1997","journal-title":"Mov Disord"},{"key":"2025042708001749000_2012.dec23_1.bcr2012007052.15","first-page":"73","article-title":"A study of SSPE: early clinical features","volume":"2","author":"Khadilkar","year":"2004","journal-title":"J Pediatr Neurol"},{"key":"2025042708001749000_2012.dec23_1.bcr2012007052.16","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.57.10.780"},{"key":"2025042708001749000_2012.dec23_1.bcr2012007052.17","first-page":"286","article-title":"Atypical chorioretinitis as the very first presentation of subacute sclerosing panencephalitis","volume":"48","author":"Caruso","year":"1997","journal-title":"Neurology"},{"key":"2025042708001749000_2012.dec23_1.bcr2012007052.18","first-page":"761","article-title":"Subacute sclerosing panencephalitis: evaluation with CT and MR","volume":"17","author":"Brismar","year":"1996","journal-title":"Am J Neuroradiol"},{"key":"2025042708001749000_2012.dec23_1.bcr2012007052.19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0733-8619(18)31062-4","article-title":"Subacute sclerosing panencephalitis","volume":"3","author":"Dyken","year":"1985","journal-title":"Neurol Clin"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2012-007052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T15:00:23Z","timestamp":1745766023000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2012-007052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,24]]},"references-count":19,"alternative-id":["10.1136\/bcr-2012-007052"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2012-007052","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2012,12,24]]}}}