{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:20:38Z","timestamp":1767651638491,"version":"3.40.4"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>A case is presented of a 23-year-old lady with treatment-resistant schizoaffective disorder who had responded well to treatment with clozapine. Fifteen months after satisfactory use of clozapine she had \u2018red alerts\u2019 from routine haematological monitoring indicating neutropenia. Clozapine was discontinued and she was admitted to the psychiatric hospital to manage the aftermath of discontinuing clozapine and start alternative treatment with other antipsychotics. Her mental health rapidly deteriorated. Adequate trials with amisulpride, haloperidol, olanzapine and flupenthixol decanoate yielded little improvement in her clinical state. After 9\u2005months of non-response to other antipsychotic medications, she was rechallenged with clozapine, followed by improvement in her mental state. She was eventually discharged home after 14\u2005months of hospitalisation in a stable mental state. She remained mentally stable in the community on clozapine for 18\u2005months after rechallenge, with no further red alerts.<\/jats:p>","DOI":"10.1136\/bcr-2012-007172","type":"journal-article","created":{"date-parts":[[2013,1,23]],"date-time":"2013-01-23T10:49:43Z","timestamp":1358938183000},"page":"bcr2012007172","source":"Crossref","is-referenced-by-count":2,"title":["Successful rechallenge with clozapine following \u2018red alert\u2019"],"prefix":"10.1136","volume":"2013","author":[{"given":"Thelma K","family":"Toni-Uebari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Rees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,1,22]]},"reference":[{"key":"2025042701404378000_2013.jan22_1.bcr2012007172.1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.188.3.255"},{"key":"2025042701404378000_2013.jan22_1.bcr2012007172.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.10.014"},{"key":"2025042701404378000_2013.jan22_1.bcr2012007172.3","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.175.6.576"},{"key":"2025042701404378000_2013.jan22_1.bcr2012007172.4","unstructured":"Taylor D Paton C Kapur S . Clozapine, neutropenia and lithium. In: Taylor D, Paton D, Kapur S, eds. The Maudsley prescribing guidelines in psychiatry. 11th edn. Hoboken, NJ: Wiley-Blackwell, 2012:84\u20137."},{"key":"2025042701404378000_2013.jan22_1.bcr2012007172.5","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1192\/bjp.169.4.483","article-title":"Neutropenia and agranulocytosis in patients receiving clozapine in the UK and Ireland","volume":"69","author":"Atkin","year":"1996","journal-title":"BJP"},{"key":"2025042701404378000_2013.jan22_1.bcr2012007172.6","first-page":"233","article-title":"Blood dyscrasias in clozapine-treated patients in Italy","volume":"85","author":"Deliliers","year":"2000","journal-title":"Haematologica"},{"key":"2025042701404378000_2013.jan22_1.bcr2012007172.7","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-199707020-00005"},{"key":"2025042701404378000_2013.jan22_1.bcr2012007172.8","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000155831.72154.bc"},{"key":"2025042701404378000_2013.jan22_1.bcr2012007172.9","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e31815a583b"},{"key":"2025042701404378000_2013.jan22_1.bcr2012007172.10","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.07111823"},{"key":"2025042701404378000_2013.jan22_1.bcr2012007172.11","doi-asserted-by":"crossref","unstructured":"Taylor D Paton C Kapur S . Refractory schizophrenia and clozapine. The Maudsley prescribing guidelines. 10th edn. Informa Healthcare, 2009:54.","DOI":"10.3109\/9780203092835"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2012-007172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T08:40:48Z","timestamp":1745743248000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2012-007172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,22]]},"references-count":11,"alternative-id":["10.1136\/bcr-2012-007172"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2012-007172","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,1,22]]}}}