{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T10:47:54Z","timestamp":1752230874346,"version":"3.40.4"},"reference-count":13,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Angiomyolipomas are rare mesenchymal tumours consisting of smooth muscle, blood vessels and adipocytes in variable proportions. These tumours are more usually seen in kidneys (incidence 0.3\u20133%), and the extrarenal location is rare. Since its initial description by Ishak in 1976, only about 200 cases of hepatic angiomyolipomas have been reported. We describe the case of a 59-year-old woman, without tuberous sclerosis, with a 6\u2005cm tumour in hepatic segments II and III, gallbladder with parietal calcification and lithiasis. She was proposed to bisegmentectomy (II and III) and cholecystectomy, which were performed without complications. The pathological examination confirmed the diagnosis of hepatic angiomyolipoma (positive for HMB45 and focally positive for HHF35) and chronic cholecystitis. Although typically benign, the emergence of cases with malignant behaviour\u2014recurrence or distant metastasis\u2014led to a change in attitude towards these lesions, from clinical surveillance to surgical excision, with few exceptions.<\/jats:p>","DOI":"10.1136\/bcr-2012-007224","type":"journal-article","created":{"date-parts":[[2012,10,11]],"date-time":"2012-10-11T14:48:36Z","timestamp":1349966916000},"page":"bcr2012007224","source":"Crossref","is-referenced-by-count":2,"title":["Sporadic exophytic hepatic angiomyolipoma"],"prefix":"10.1136","volume":"2012","author":[{"given":"S\u00edlvia","family":"Costa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Tente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Maciel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,10,11]]},"reference":[{"doi-asserted-by":"publisher","key":"2025042707173412000_2012.oct09_1.bcr2012007224.1","DOI":"10.1097\/00000478-199901000-00004"},{"doi-asserted-by":"publisher","key":"2025042707173412000_2012.oct09_1.bcr2012007224.2","DOI":"10.1016\/j.humpath.2006.01.028"},{"key":"2025042707173412000_2012.oct09_1.bcr2012007224.3","first-page":"152","article-title":"Diagnostic analysis of hepatic angiomyolipoma","volume":"4","author":"Jiang","year":"2005","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"2025042707173412000_2012.oct09_1.bcr2012007224.4","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1016\/S0022-5347(17)35895-0","article-title":"The natural history of renal angiomyolipoma","volume":"150","author":"Steiner","year":"1993","journal-title":"J Urol"},{"key":"2025042707173412000_2012.oct09_1.bcr2012007224.5","first-page":"1317","article-title":"A case of extrarenal angiomyolipoma with intestinal localization","volume":"47","author":"Verzaro","year":"1992","journal-title":"Minerva Chir"},{"unstructured":"Ishak KG . Mesenchymal tumors of the liver. In: Okuda K Peters RL , eds. Hepatocellular carcinoma. New York: John Wiley & Sons, 1976, 247\u2013307.","key":"2025042707173412000_2012.oct09_1.bcr2012007224.6"},{"doi-asserted-by":"publisher","key":"2025042707173412000_2012.oct09_1.bcr2012007224.7","DOI":"10.1007\/s11605-006-0037-3"},{"key":"2025042707173412000_2012.oct09_1.bcr2012007224.8","first-page":"65","article-title":"Characteristics and treatment strategy of hepatic angiomyolipoma: a series of 94 patients collected from four institutions","volume":"20","author":"Chang","year":"2011","journal-title":"J Gastrointestin Liver Dis"},{"doi-asserted-by":"publisher","key":"2025042707173412000_2012.oct09_1.bcr2012007224.9","DOI":"10.1007\/s00428-007-0509-1"},{"doi-asserted-by":"publisher","key":"2025042707173412000_2012.oct09_1.bcr2012007224.10","DOI":"10.3348\/kjr.2008.9.1.67"},{"doi-asserted-by":"publisher","key":"2025042707173412000_2012.oct09_1.bcr2012007224.11","DOI":"10.3748\/wjg.14.812"},{"doi-asserted-by":"publisher","key":"2025042707173412000_2012.oct09_1.bcr2012007224.12","DOI":"10.1046\/j.1365-2559.2000.00891.x"},{"doi-asserted-by":"publisher","key":"2025042707173412000_2012.oct09_1.bcr2012007224.13","DOI":"10.1097\/00042737-200012050-00018"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2012-007224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T14:17:43Z","timestamp":1745763463000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2012-007224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,11]]},"references-count":13,"alternative-id":["10.1136\/bcr-2012-007224"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2012-007224","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2012,10,11]]}}}