{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T21:36:11Z","timestamp":1770413771649,"version":"3.49.0"},"reference-count":22,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Melanoma has been found to metastasise to the spleen, usually in cases of disseminated disease. Solitary splenic metastasis from cutaneous melanoma is very rare. Herein we report the case of a 43-year-old man who developed solitary splenic metastasis from cutaneous melanoma. The patient was operated for T<jats:sub>4b<\/jats:sub>N<jats:sub>1a<\/jats:sub>Mo superficial spreading melanoma of the anterior thoracic wall. He subsequently underwent left axillary lymph node dissection due to a positive sentinel lymph node. The 33 retrieved lymph nodes were negative for metastasis. The patient received adjuvant therapy with high-dose interferon \u03b1-2b. After 27\u2005months and during the follow-up visit an increasing lactate dehydrogenase serum level was observed. Furthermore, CT of the whole body revealed a solitary hypodense tumour of the spleen 9\u2005cm\u00d76\u2005cm. Curative splenectomy was performed and the histopathological report confirmed metastatic melanoma to the spleen.<\/jats:p>","DOI":"10.1136\/bcr-2012-007317","type":"journal-article","created":{"date-parts":[[2012,10,26]],"date-time":"2012-10-26T15:49:38Z","timestamp":1351266578000},"page":"bcr2012007317","source":"Crossref","is-referenced-by-count":4,"title":["Solitary metachronous splenic metastasis from cutaneous melanoma"],"prefix":"10.1136","volume":"2012","author":[{"given":"Paschalis","family":"Gavriilidis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni","family":"Goupou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,10,26]]},"reference":[{"key":"2025042707251794000_2012.oct24_2.bcr2012007317.1","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-200106000-00020"},{"key":"2025042707251794000_2012.oct24_2.bcr2012007317.2","doi-asserted-by":"publisher","DOI":"10.4103\/0972-9941.51316"},{"key":"2025042707251794000_2012.oct24_2.bcr2012007317.3","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(03)00381-8"},{"key":"2025042707251794000_2012.oct24_2.bcr2012007317.4","doi-asserted-by":"publisher","DOI":"10.1007\/BF01655283"},{"key":"2025042707251794000_2012.oct24_2.bcr2012007317.5","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199210000-00017"},{"key":"2025042707251794000_2012.oct24_2.bcr2012007317.6","doi-asserted-by":"publisher","DOI":"10.1158\/ajc.1934.517"},{"key":"2025042707251794000_2012.oct24_2.bcr2012007317.7","first-page":"442","article-title":"Secondary carcinoma of the spleen its incidence in 544 cases and review of the literature","volume":"58","author":"Nash","year":"1966","journal-title":"J Natl Med Assoc"},{"key":"2025042707251794000_2012.oct24_2.bcr2012007317.8","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1200\/JCO.2001.19.16.3635","article-title":"Final version of the American Joint Committee on cancer staging system for cutaneous melanoma","volume":"19","author":"Balch","year":"2001","journal-title":"J Clin Oncol"},{"key":"2025042707251794000_2012.oct24_2.bcr2012007317.9","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1200\/JCO.1983.1.2.126","article-title":"A multifactorial analysis of melanoma: prognostic factors in 200 melanoma patients with distant metastases","volume":"1","author":"Balch","year":"1983","journal-title":"J Clin Oncol"},{"key":"2025042707251794000_2012.oct24_2.bcr2012007317.10","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0022-5223(19)34957-8","article-title":"Analysis of 945 cases of pulmonary metastatic melanoma","volume":"103","author":"Harpole","year":"1992","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2025042707251794000_2012.oct24_2.bcr2012007317.11","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1001\/archsurg.1964.01310240065013","article-title":"Metastatic melanoma of gastrointestinal tract","volume":"88","author":"Das Gupta","year":"1964","journal-title":"Arch Surg"},{"key":"2025042707251794000_2012.oct24_2.bcr2012007317.12","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(78)90171-X"},{"key":"2025042707251794000_2012.oct24_2.bcr2012007317.13","first-page":"3427","article-title":"Patterned distribution of metastases from malignant melanoma in humans","volume":"43","author":"De la Monte","year":"1983","journal-title":"Cancer Res"},{"key":"2025042707251794000_2012.oct24_2.bcr2012007317.14","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0960-7404(10)80014-3","article-title":"Gastrointestinal metastases from malignant melanoma","volume":"4","author":"Ricaniadis","year":"1995","journal-title":"Surg Oncol"},{"key":"2025042707251794000_2012.oct24_2.bcr2012007317.15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.1.125"},{"key":"2025042707251794000_2012.oct24_2.bcr2012007317.16","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1996.01430210073013"},{"key":"2025042707251794000_2012.oct24_2.bcr2012007317.17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1177\/030089169207800111","article-title":"Spontaneous rupture of spleen in a patient with splenic metastasis of melanoma. 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