{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:10:04Z","timestamp":1756278604539,"version":"3.44.0"},"reference-count":20,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2012,10,9]]},"abstract":"<jats:p>Kallmann syndrome (KS) is a genetically heterogeneous and rare disorder characterised by the combination of hypothalamic hypogonadism and anosmia\/hyposmia, a variable degree of intellectual disability and several somatic anomalies. In about one-third of the patients, mutations have been identified in at least seven different genes. Virtually no data are available about possible neuropsychiatric symptoms in KS. Here, a young adult male is described with a previous clinical diagnosis of KS and recent paranoid schizophrenia of which positive, but not negative symptoms, fully remitted upon treatment with antipsychotics. Neither genome-wide array analysis nor mutation analyses disclosed imbalances or mutations in any of presently known KS disease genes. This is the first report on a patient with KS and paranoid schizophrenia in whom extensive genetic analyses were performed. It is concluded that further studies are warranted in order to elucidate a possible increased risk for psychiatric symptoms in patients with KS.<\/jats:p>","DOI":"10.1136\/bcr-2012-007387","type":"journal-article","created":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T01:53:20Z","timestamp":1358474000000},"page":"bcr2012007387","source":"Crossref","is-referenced-by-count":4,"title":["Kallmann syndrome and paranoid schizophrenia: a rare combination"],"prefix":"10.1136","volume":"2013","author":[{"given":"Willem M A","family":"Verhoeven","sequence":"first","affiliation":[{"name":"Centre of Excellence for Neuropsychiatry, Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands"},{"name":"Department of Psychiatry, Erasmus University Medical Centre, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos I M","family":"Egger","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Neuropsychiatry, Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands"},{"name":"Radboud University Nijmegen, Behavioural Science Institute and Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes E","family":"Hovens","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Delta Psychiatric Centre, Poortugaal, The Netherlands"},{"name":"Institute of Psychology, Erasmus University, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lies","family":"Hoefsloot","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,1,17]]},"reference":[{"key":"2025082623405621000_2013.jan16_1.bcr2012007387.1","first-page":"213","article-title":"The genetic aspects of primary eunuchoidism","volume":"48","author":"Kallmann","year":"1944","journal-title":"Am J Ment Def"},{"key":"2025082623405621000_2013.jan16_1.bcr2012007387.2","first-page":"1267","article-title":"La dysplasia olfacto-genitale","volume":"11","author":"De Morsier","year":"1963","journal-title":"Pathol Biol (Paris)"},{"key":"2025082623405621000_2013.jan16_1.bcr2012007387.3","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410190211"},{"key":"2025082623405621000_2013.jan16_1.bcr2012007387.4","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90193-3"},{"key":"2025082623405621000_2013.jan16_1.bcr2012007387.5","doi-asserted-by":"publisher","DOI":"10.1038\/353529a0"},{"key":"2025082623405621000_2013.jan16_1.bcr2012007387.6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1998.00406.x"},{"key":"2025082623405621000_2013.jan16_1.bcr2012007387.7","doi-asserted-by":"crossref","unstructured":"Krams M Quinton R Ashburner J . Kallmann's syndrome. Mirror movements associated with bilateral corticospinal tract hypertrophy. 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