{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:39:10Z","timestamp":1789958350332,"version":"4.0.1"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>\u03b2-blocker and calcium channel blocker toxicity generally present with bradycardia and hypotension. A 69-year-old woman presented after a suicide attempt with a \u03b2-blocker and calcium channel blocker overdose. Her blood pressure was 69\/35\u2005mm\u2005Hg and her HR was in the 40s. She was treated with calcium chloride, glucagon, a dextrose\u2013insulin infusion and three vasopressors, but remained hypotensive. She suffered two cardiac arrests and required a transvenous pacemaker. When all interventions failed, she was started on a methylene blue infusion for refractory vasodilatory shock which resulted in a dramatic improvement in her blood pressure. The patient was successfully weaned off all vasopressors and from mechanical ventilation without any end-organ damage.<\/jats:p>","DOI":"10.1136\/bcr-2012-007402","type":"journal-article","created":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T23:37:14Z","timestamp":1358552234000},"page":"bcr2012007402","source":"Crossref","is-referenced-by-count":30,"title":["Methylene blue reverses recalcitrant shock in \u03b2-blocker and calcium channel blocker overdose"],"prefix":"10.1136","volume":"2013","author":[{"given":"Nidhi","family":"Aggarwal","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Pulmonary & Critical Care Medicine, Maimonides Medical Center, Brooklyn, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhak","family":"Kupfer","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Pulmonary & Critical Care Medicine, Maimonides Medical Center, Brooklyn, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanaka","family":"Seneviratne","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Pulmonary & Critical Care Medicine, Maimonides Medical Center, Brooklyn, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidney","family":"Tessler","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Pulmonary & Critical Care Medicine, Maimonides Medical Center, Brooklyn, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,1,18]]},"reference":[{"key":"2025082802111948000_2013.jan18_1.bcr2012007402.1","doi-asserted-by":"publisher","DOI":"10.1159\/000074241"},{"key":"2025082802111948000_2013.jan18_1.bcr2012007402.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.03.028"},{"key":"2025082802111948000_2013.jan18_1.bcr2012007402.3","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.002907"},{"key":"2025082802111948000_2013.jan18_1.bcr2012007402.4","unstructured":"Westfall TC Westfall DP . Adrenergec agonists and antagonists. In: Brunton LL Lazo JS Parker KL , eds. Goodman & Gillman's The pharmacological basis of therapeutics. 11th edn. 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