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Here we report a case of Wilson disease with neurological manifestations in a 7-year-old girl with concurrent asymptomatic liver involvement and characteristic radiological findings of signal intensity alterations in bilateral striata and thalami along with changes in central pons too like central pontine myelinolysis (CPM), which is of rare occurrence.<\/jats:p>","DOI":"10.1136\/bcr-2012-007408","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T08:55:26Z","timestamp":1369299326000},"page":"bcr2012007408","source":"Crossref","is-referenced-by-count":2,"title":["Central pontine myelinolysis associated with Wilson disease in a 7-year-old child"],"prefix":"10.1136","volume":"2013","author":[{"given":"Rajesh","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dheeraj","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,5,22]]},"reference":[{"key":"2025082707273124000_2013.may22_1.bcr2012007408.1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/ng1293-327","article-title":"The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene","volume":"2013","author":"Bull","year":"1993","journal-title":"Nat Genet"},{"key":"2025082707273124000_2013.may22_1.bcr2012007408.2","unstructured":"Schilsky M, Tavill AS . Wilson disease. In: Schiff ER Forbes JR Cox DW . eds. Disease of the liver, 9th edn., Philadelphia: Lippincott Williams & Wilkins, 2003:1169\u201386."},{"key":"2025082707273124000_2013.may22_1.bcr2012007408.3","unstructured":"Le Witt P Pfeiffe R . Neurologic aspects of Wilson's disease: clinical manifestations and treatment considerations. In: Jankovic JJ Tolosa E , eds. Parkinson's disease and movement disorders. 4th edn. Philadelphia: Lippincott Williams & Wilkins, 2002:240\u201355."},{"key":"2025082707273124000_2013.may22_1.bcr2012007408.4","first-page":"39","article-title":"Recognition, diagnosis, and management of Wilson's disease","volume":"2013","author":"Brewer","year":"2000","journal-title":"Soc Exp Biol Med,"},{"key":"2025082707273124000_2013.may22_1.bcr2012007408.5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1749-6632.2009.05109.x","article-title":"Neurologic Wilson's disease","volume":"2013","author":"Lorincz","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"2025082707273124000_2013.may22_1.bcr2012007408.6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1136\/gut.2005.087262","article-title":"Clinical presentation, diagnosis and long-term outcome of Wilson's disease: a cohort study","volume":"2013","author":"Merle","year":"2007","journal-title":"Gut"},{"key":"2025082707273124000_2013.may22_1.bcr2012007408.7","unstructured":"Menkes JH Wilcox WR . Inherited metabolic diseases of the nervous system. In: Menkes JH Sarnat HB Maria BL , eds. Child Neurology. 7th edn. Lippincott Williams & Wilkins, 2006:109 15."},{"key":"2025082707273124000_2013.may22_1.bcr2012007408.8","first-page":"743","article-title":"Neurological Wilson disease in children: a three years experience from Multan","volume":"2013","author":"Noureen","year":"2011","journal-title":"J Pak Med Assoc"},{"key":"2025082707273124000_2013.may22_1.bcr2012007408.9","unstructured":"Scheinberg IH Sternlieb I . Wilson's disease. Philadelphia, PA: W B Saunders, 1984."},{"key":"2025082707273124000_2013.may22_1.bcr2012007408.10","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1080\/02841859709172059","article-title":"MR findings in WD","volume":"2013","author":"Saatci","year":"1997","journal-title":"Acta Radiol"},{"key":"2025082707273124000_2013.may22_1.bcr2012007408.11","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00234-006-0101-4","article-title":"Wilson's disease: cranial MRI observations and clinical correlation","volume":"2013","author":"Sinha","year":"2006","journal-title":"Neuroradiology"},{"key":"2025082707273124000_2013.may22_1.bcr2012007408.12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.mri.2003.08.004","article-title":"Central pontine myelinolysis in Wilson's disease: MR spectroscopy findings","volume":"2013","author":"Kizkin","year":"2004","journal-title":"Magn Reson Imaging"},{"key":"2025082707273124000_2013.may22_1.bcr2012007408.13","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1552-6569.2007.00120.x","article-title":"Central pontine signal changes in Wilson's disease: distinct MRI morphology and sequential changes with de-coppering therapy","volume":"2013","author":"Sinha","year":"2007","journal-title":"J Neuroimaging"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2012-007408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:27:41Z","timestamp":1756304861000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2012-007408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,22]]},"references-count":13,"alternative-id":["10.1136\/bcr-2012-007408"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2012-007408","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,5,22]]}}}