{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:28:31Z","timestamp":1760549311718,"version":"3.40.4"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Doxylamine succinate, an H<jats:sub>1<\/jats:sub>-antihistamine drug, is commonly used as sleep-inducing agent as well as therapy for nausea and vomiting in pregnancy. At usual doses, it may cause impairment of cognitive and psychomotor performance, anticholinergic effects, agitation and postural hypotension. Besides, since this drug is frequently involved in either accidental or intentional overdoses, it seems relevant to bear in mind other possible toxic effects. We report a case of acute severe hyponatremia in the setting of a syndrome of inappropriate antidiuresis (SIAD), an apparent new adverse effect linked to doxylamine overdose. The Naranjo adverse drug reaction probability scale indicated a probable relationship between doxylamine intake and SIAD development. SIAD may be considered as a potential, serious adverse reaction of doxylamine overdose. Clinicians should consider this aetiological possibility when attending patients suffering from hyponatremia.<\/jats:p>","DOI":"10.1136\/bcr-2012-007428","type":"journal-article","created":{"date-parts":[[2012,11,19]],"date-time":"2012-11-19T16:35:44Z","timestamp":1353342944000},"page":"bcr-2012-007428","source":"Crossref","is-referenced-by-count":7,"title":["Syndrome of inappropriate antidiuresis in doxylamine overdose"],"prefix":"10.1136","volume":"2012","author":[{"given":"Miguel F","family":"Carrascosa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9-Ram\u00f3n Salcines","family":"Caviedes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Isabel","family":"Lucena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Cuadrado-Lav\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,11,19]]},"reference":[{"key":"2025042707342238000_2012.nov16_1.bcr-2012-007428.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra033121"},{"key":"2025042707342238000_2012.nov16_1.bcr-2012-007428.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60750-2"},{"key":"2025042707342238000_2012.nov16_1.bcr-2012-007428.3","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e328342d208"},{"key":"2025042707342238000_2012.nov16_1.bcr-2012-007428.4","doi-asserted-by":"crossref","unstructured":"Syed H Som S Khan N . \u00a0Doxylamine toxicity: seizure, rhabdomyolysis and false positive urine drug screen for methadone. BMJ Case Rep 2009;10.1136\/bcr.09.2008.0879, Published 17 March 2009.","DOI":"10.1136\/bcr.09.2008.0879"},{"key":"2025042707342238000_2012.nov16_1.bcr-2012-007428.5","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10053"},{"key":"2025042707342238000_2012.nov16_1.bcr-2012-007428.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp066837"},{"key":"2025042707342238000_2012.nov16_1.bcr-2012-007428.7","doi-asserted-by":"publisher","DOI":"10.1159\/000324653"},{"key":"2025042707342238000_2012.nov16_1.bcr-2012-007428.8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.306.6871.186-a"},{"key":"2025042707342238000_2012.nov16_1.bcr-2012-007428.9","unstructured":"Lexi-InteractTM Online . Lexi-Comp's Comprehensive Drug-to-Drug, Drug-to-Herb and Herb-to-Herb Interaction Analysis Program. http:\/\/www.uptodate.com\/crlsql\/interact\/frameset.jsp(last accessed 14 May 2012)."},{"key":"2025042707342238000_2012.nov16_1.bcr-2012-007428.10","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"2025042707342238000_2012.nov16_1.bcr-2012-007428.11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc062840"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2012-007428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T14:34:28Z","timestamp":1745764468000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2012-007428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,19]]},"references-count":11,"alternative-id":["10.1136\/bcr-2012-007428"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2012-007428","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2012,11,19]]}}}