{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:10:05Z","timestamp":1756372205263,"version":"3.44.0"},"reference-count":9,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Vascular (type IV) Ehlers-Danlos is an autosomally dominant inherited condition that results from a defect in type III collagen production. It can result in vascular complications such as rupture and dissection, as well as gastrointestinal and uterine rupture. We present the case of a 17-year-old girl who presented with transient neurological signs and pulsatile tinnitus secondary to carotid dissection 1\u2005year after suffering from a stroke caused also by a carotid dissection on the contralateral side. We managed acutely and investigated for an underlying connective tissue disorder. Genetic analysis of COL 3A1 was performed and a heterozygous missense, non-conservative mutation of c.970G&gt;A was detected. This replication mutation has previously been associated with type IV Ehlers-Danlos syndrome.<\/jats:p>","DOI":"10.1136\/bcr-2012-007435","type":"journal-article","created":{"date-parts":[[2012,12,12]],"date-time":"2012-12-12T10:37:26Z","timestamp":1355308646000},"page":"bcr2012007435","source":"Crossref","is-referenced-by-count":2,"title":["Type IV Ehlers-Danlos syndrome presenting as recurrent, bilateral carotid dissections"],"prefix":"10.1136","volume":"2012","author":[{"given":"Richard James Booth","family":"Ellis","sequence":"first","affiliation":[{"name":"Department of Care of the Elderly and Stroke Medicine, Leighton Hospital, Crewe, Cheshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maqsud","family":"Salehin","sequence":"additional","affiliation":[{"name":"Department of Care of the Elderly and Stroke Medicine, Leighton Hospital, Crewe, Cheshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Care of the Elderly and Stroke Medicine, Leighton Hospital, Crewe, Cheshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Somauroo","sequence":"additional","affiliation":[{"name":"Department of Care of the Elderly and Stroke Medicine, Leighton Hospital, Crewe, Cheshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,12,12]]},"reference":[{"key":"2025082801461009000_2012.dec11_1.bcr2012007435.1","unstructured":"Dalgleish R . Leiden Open Variation Database (LOVD). Ehlers-Danlos Syndrome Variant Database. https:\/\/eds.gene.le.ac.uk\/variants.php?select_db=COL3A1&action=view_all&view=DNA_sub (accessed 23 Jul 2012)."},{"key":"2025082801461009000_2012.dec11_1.bcr2012007435.2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.64.070195.002155"},{"key":"2025082801461009000_2012.dec11_1.bcr2012007435.3","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0b013e3182342316"},{"key":"2025082801461009000_2012.dec11_1.bcr2012007435.4","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-32"},{"key":"2025082801461009000_2012.dec11_1.bcr2012007435.5","doi-asserted-by":"publisher","DOI":"10.1007\/s11936-996-0018-6"},{"key":"2025082801461009000_2012.dec11_1.bcr2012007435.6","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jns.2012.04.005","article-title":"Multiple strokes and bilateral carotid dissections: a fulminant case of newly diagnosed Ehlers-Danlos syndrome type IV","volume":"318","author":"Dohle","year":"2012","journal-title":"J Neuro Sci"},{"key":"2025082801461009000_2012.dec11_1.bcr2012007435.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-3787(04)70934-0"},{"key":"2025082801461009000_2012.dec11_1.bcr2012007435.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.10.035"},{"key":"2025082801461009000_2012.dec11_1.bcr2012007435.9","doi-asserted-by":"publisher","DOI":"10.1080\/14767050902874071"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2012-007435","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:46:17Z","timestamp":1756370777000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2012-007435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,12]]},"references-count":9,"alternative-id":["10.1136\/bcr-2012-007435"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2012-007435","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2012,12,12]]}}}