{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:40:09Z","timestamp":1756374009051,"version":"3.44.0"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Homocysteinuria is a rare inborn error of metabolism known to be associated with an increased risk of vascular events. A 36-year-old Caucasian man presented with a 2day history of epigastric discomfort associated with nausea and sweating. He has a history of homocysteinuria and had been poorly compliant with treatment. An ECG showed ST-segment elevation and Q-waves in anterior leads. Blood tests showed markedly elevated high-sensitivity troponin and high homocysteine levels. He had a failed primary percutaneous coronary intervention due to extensive thrombus in the left anterior descending artery, which was aspirated and he received integrelin infusion for 48\u2005h. Echocardiogram showed mild-to-moderate impairment of left ventricular function with apical akinesis extending to the mid-portion of anteroseptal walls consistent with anterior myocardial infarction. He was started on homocysteine-lowering treatment with betaine and folic acid. He is now on follow-up with clinical chemistry and cardiac rehabilitation.<\/jats:p>","DOI":"10.1136\/bcr-2012-007489","type":"journal-article","created":{"date-parts":[[2012,11,9]],"date-time":"2012-11-09T11:44:01Z","timestamp":1352461441000},"page":"bcr2012007489","source":"Crossref","is-referenced-by-count":3,"title":["Acute myocardial infarction in a young patient with hyperhomocysteinaemia"],"prefix":"10.1136","volume":"2012","author":[{"given":"Vincent","family":"Ukachukwu","sequence":"first","affiliation":[{"name":"Emergency Department, Ulster Hospital, Belfast, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salah","family":"Idris","sequence":"additional","affiliation":[{"name":"Emergency Department, Ulster Hospital, Belfast, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alister","family":"McIlwee","sequence":"additional","affiliation":[{"name":"Emergency Department, Ulster Hospital, Belfast, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,11,9]]},"reference":[{"key":"2025082802215656000_2012.nov07_1.bcr2012007489.1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.16.2015"},{"key":"2025082802215656000_2012.nov07_1.bcr2012007489.2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/24.4.704"},{"key":"2025082802215656000_2012.nov07_1.bcr2012007489.3","first-page":"1","article-title":"The natural history of homocystinuria due to cystathionine-synthase deficiency","volume":"37","author":"Mudd","year":"1985","journal-title":"Am J Hum Genet"},{"key":"2025082802215656000_2012.nov07_1.bcr2012007489.4","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005373209964"},{"key":"2025082802215656000_2012.nov07_1.bcr2012007489.5","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-8100"},{"key":"2025082802215656000_2012.nov07_1.bcr2012007489.6","doi-asserted-by":"publisher","DOI":"10.1161\/hq1201.100225"},{"key":"2025082802215656000_2012.nov07_1.bcr2012007489.7","unstructured":"American Heart Association. Stroke deaths reduced by folic acid fortification: meeting report. 5 March 2004. http:\/\/scienceblog.com\/community\/older\/2004\/1\/2004533.shtml (accessed 14 Aug 2012)."},{"key":"2025082802215656000_2012.nov07_1.bcr2012007489.8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.5.565"},{"key":"2025082802215656000_2012.nov07_1.bcr2012007489.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011364"},{"key":"2025082802215656000_2012.nov07_1.bcr2012007489.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032845"},{"key":"2025082802215656000_2012.nov07_1.bcr2012007489.11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055227"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2012-007489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:22:02Z","timestamp":1756372922000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2012-007489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,9]]},"references-count":11,"alternative-id":["10.1136\/bcr-2012-007489"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2012-007489","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2012,11,9]]}}}