{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:01:34Z","timestamp":1762866094500,"version":"3.44.0"},"reference-count":21,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Angiosarcomas are rare malignant tumours that arise from endothelial cells lining vascular channels, representing 0.04% of malignant neoplasms of the breast. Breast angiosarcomas (BAs) were first described by Schmidt in 1887, and may be primary or secondary to the pre-existing conditions. Primary BAs are more common in young women and present as a palpable mass. Secondary BAs arise in older patients, frequently 5\u20136\u2005years after radiotherapy, and present as a rash.The authors describe the case of an 83-year-old woman with no history of thoracic radiotherapy or surgery. She had been observed for a breast nodule where biopsy revealed phyllodes tumour. The patient refused surgery and returned 2\u2005years later because of an impressive increase in tumour volume and skin ulceration. She underwent mastectomy with local skin flaps. Histopathological result revealed high-grade angiosarcoma of 15\u00d712\u2005cm. There was follow-up without evidence of recurrence, after radiotherapy.<\/jats:p>","DOI":"10.1136\/bcr-2012-007545","type":"journal-article","created":{"date-parts":[[2012,12,3]],"date-time":"2012-12-03T13:13:30Z","timestamp":1354540410000},"page":"bcr2012007545","source":"Crossref","is-referenced-by-count":7,"title":["Breast angiosarcoma secondary to phyllodes tumour"],"prefix":"10.1136","volume":"2012","author":[{"given":"S\u00edlvia","family":"Costa","sequence":"first","affiliation":[{"name":"Department of General Surgery, Centro Hospitalar Gaia\/Espinho, EPE, Gaia, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana Alexandra Rodrigues","family":"Gra\u00e7a","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Centro Hospitalar Gaia\/Espinho, EPE, Gaia, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f3nio","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Centro Hospitalar Gaia\/Espinho, EPE, Gaia, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Maciel","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Centro Hospitalar Gaia\/Espinho, EPE, Gaia, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,12,3]]},"reference":[{"key":"2025082804364596000_2012.dec03_1.bcr2012007545.1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/00000478-198110000-00005","article-title":"Angiosarcoma and other vascular tumors of the breast","volume":"5","author":"Donnell","year":"1981","journal-title":"Am J Surg Pathol"},{"key":"2025082804364596000_2012.dec03_1.bcr2012007545.2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19881115)62:10<2145::AID-CNCR2820621014>3.0.CO;2-O"},{"key":"2025082804364596000_2012.dec03_1.bcr2012007545.3","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800715)46:2<368::AID-CNCR2820460226>3.0.CO;2-E"},{"key":"2025082804364596000_2012.dec03_1.bcr2012007545.4","first-page":"421","article-title":"Ueber das Angiosarkom der Mamma","volume":"36","author":"Schmidt","year":"1887","journal-title":"Arch Klin Chir"},{"key":"2025082804364596000_2012.dec03_1.bcr2012007545.5","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2423060163"},{"key":"2025082804364596000_2012.dec03_1.bcr2012007545.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02293.x"},{"key":"2025082804364596000_2012.dec03_1.bcr2012007545.7","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/jso.21497","article-title":"Primary and secondary angiosarcoma of the breast: the Mayo clinic experience","volume":"101","author":"Scow","year":"2010","journal-title":"J Surg Oncol"},{"key":"2025082804364596000_2012.dec03_1.bcr2012007545.8","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22784"},{"key":"2025082804364596000_2012.dec03_1.bcr2012007545.9","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1148\/radiology.183.3.1584913","article-title":"Angiosarcoma of the breast","volume":"183","author":"Liberman","year":"1992","journal-title":"Radiology"},{"key":"2025082804364596000_2012.dec03_1.bcr2012007545.10","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2214\/ajr.184.1.01840331","article-title":"Vascular tumors of the breast: mammographic, sonographic, and MRI appearances","volume":"184","author":"Glazebrook","year":"2005","journal-title":"Am J Roentgenol"},{"key":"2025082804364596000_2012.dec03_1.bcr2012007545.11","doi-asserted-by":"publisher","DOI":"10.1159\/000264637"},{"key":"2025082804364596000_2012.dec03_1.bcr2012007545.12","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF00666044","article-title":"Antibody-directed targeting of the vasculature of solid tumors","volume":"36","author":"Thorpe","year":"1995","journal-title":"Breast Cancer Res Treat"},{"key":"2025082804364596000_2012.dec03_1.bcr2012007545.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2004.10.007"},{"key":"2025082804364596000_2012.dec03_1.bcr2012007545.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)02669-4"},{"key":"2025082804364596000_2012.dec03_1.bcr2012007545.15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.11.072"},{"key":"2025082804364596000_2012.dec03_1.bcr2012007545.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2007.10.015"},{"key":"2025082804364596000_2012.dec03_1.bcr2012007545.17","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318176dbc7"},{"key":"2025082804364596000_2012.dec03_1.bcr2012007545.18","unstructured":"Stavros AT . 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