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Key-investigation results were as follows: (1) pleural fluid was sterile and exudative, with no malignant cells, (2) erythrocyte sedimentation rate, C reactive protein and D-dimer were raised, (3) antinuclear antibody, anti-dsDNA and antihistone antibodies were newly positive, (4) imaging revealed a large left ventricular mass consistent with thrombus in the absence of evidence of a myocardial infarction. Based on the above investigations we hypothesised that carbimazole had induced systemic lupus erythematosus, manifesting as serositis resulting in an exudative pleural effusion and a proinflammatory\/prothrombotic state. Carbimazole was stopped. The patient's pleural effusion completely resolved and she remains asymptomatic.<\/jats:p>","DOI":"10.1136\/bcr-2012-007596","type":"journal-article","created":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T04:24:04Z","timestamp":1360211044000},"page":"bcr2012007596","source":"Crossref","is-referenced-by-count":9,"title":["Carbimazole-induced lupus"],"prefix":"10.1136","volume":"2013","author":[{"given":"Ihteshamul","family":"Haq","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Nottingham University Hospitals NHS Trust, Queen's Medical Centre, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D","family":"Sosin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nottingham University Hospitals NHS Trust, Queen's Medical Centre, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Wharton","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Nottingham University Hospitals NHS Trust, Queen's Medical Centre, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anindya","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Nottingham University Hospitals NHS Trust, Queen's Medical Centre, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,2,7]]},"reference":[{"key":"2025082722415408000_2013.feb06_1.bcr2012007596.1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200301000-00013"},{"key":"2025082722415408000_2013.feb06_1.bcr2012007596.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2004.05.006"},{"key":"2025082722415408000_2013.feb06_1.bcr2012007596.3","doi-asserted-by":"crossref","unstructured":"Merola JF . 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