{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:28:24Z","timestamp":1785932904097,"version":"3.56.0"},"reference-count":16,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>A 51-year-old Japanese woman developed systemic lupus erythematosus (SLE) in 1995. In August 2005, she had massive pericardial effusion due to lupus pericarditis, which was compromising her circulation. Methylprednisolone pulse, intravenous cyclophosphamide pulse and pericardiocentesis were all ineffective. The pericardium was cut surgically to create a passage to drain the liquid into the pleural cavity. The procedure was temporarily effective; however, massive liquid accumulated in the pleural cavity within 1\u2005year. Oral tacrolimus and topical betamethasone injection were ineffective. Since the interleukin-6 (IL-6) level in the effusion was markedly increased (1160\u2005pg\/ml), tocilizumab was administered intravenously at a dose of 8\u2005mg\/kg every 4\u2005weeks. The effect was astonishing and only a residual amount of pericardial effusion remained. Prednisolone was tapered successfully from 15 to 5\u2005mg daily. Tocilizumab is a treatment of choice when we confront an intractable serositis with massive effusion in SLE, if the IL-6 level is high.<\/jats:p>","DOI":"10.1136\/bcr-2012-007834","type":"journal-article","created":{"date-parts":[[2012,12,22]],"date-time":"2012-12-22T03:37:04Z","timestamp":1356147424000},"page":"bcr2012007834","source":"Crossref","is-referenced-by-count":25,"title":["Successful treatment of massive intractable pericardial effusion in a patient with systemic lupus erythematosus with tocilizumab"],"prefix":"10.1136","volume":"2012","author":[{"given":"Yasuyuki","family":"Kamata","sequence":"first","affiliation":[{"name":"Division of Rheumatology and Clinical Immunology, Jichi Medical University, Shimotsuke-shi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Minota","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Clinical Immunology, Jichi Medical University, Shimotsuke-shi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2012,12,21]]},"reference":[{"key":"2025082707105254000_2012.dec21_1.bcr2012007834.1","doi-asserted-by":"publisher","DOI":"10.4065\/74.3.275"},{"key":"2025082707105254000_2012.dec21_1.bcr2012007834.2","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1590\/S0066-782X2000001100008","article-title":"Cardiac tamponade in systemic lupus erythematosus. 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