{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:25:52Z","timestamp":1780482352756,"version":"3.54.1"},"reference-count":14,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Agenesis of maxillary lateral incisors and mandibular second premolars is the most frequent form of hypodontia. Its prevalence varies across population from 0.8% to 4.5%. Genetic aberrations and environmental factors may cause agenesis of one or more teeth. The management of child having such a problem is very important since diastema in teeth especially in upper anteriors not only affects child's physical appearance but also its psychological development as the child wants to look like other children. In this article is presented a case of non-syndromic agenesis of maxillary lateral incisors (MLIA) and mandibular central incisors in a 10-year-old boy (patient) in permanent dentition with its management along with the radiographic investigations and photographic presentations of the other members of his family affected with this condition.<\/jats:p>","DOI":"10.1136\/bcr-2012-007846","type":"journal-article","created":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T23:30:47Z","timestamp":1364340647000},"page":"bcr2012007846","source":"Crossref","is-referenced-by-count":7,"title":["Familial aggregation of maxillary lateral incisor agenesis (MLIA)"],"prefix":"10.1136","volume":"2013","author":[{"given":"Pallavi","family":"Pandey","sequence":"first","affiliation":[{"name":"Department of Pedodontics & Preventive Dentistry, Career Post Graduate Institute of Dental Sciences & Hospital, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afroz Alam","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Pedodontics & Preventive Dentistry, KGMU (Erstwhile KGMC), Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartik","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Department of Pedodontics & Preventive Dentistry, Career Post Graduate Institute of Dental Sciences & Hospital, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Pedodontics & Preventive Dentistry, Career Post Graduate Institute of Dental Sciences & Hospital, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,3,26]]},"reference":[{"key":"2025082804023952000_2013.mar26_1.bcr2012007846.1","first-page":"348","article-title":"Numerical variations in primary dentition and their correlation with the permanent dentition","volume":"12","author":"Grahnen","year":"1961","journal-title":"Odont Rev"},{"issue":"Suppl 3","key":"2025082804023952000_2013.mar26_1.bcr2012007846.2","first-page":"1","article-title":"Hypodontia in the permanent dentition. A clinical and genetic investigation","volume":"7","author":"Grahnen","year":"1956","journal-title":"Odont Rev"},{"key":"2025082804023952000_2013.mar26_1.bcr2012007846.3","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(66)90122-9"},{"key":"2025082804023952000_2013.mar26_1.bcr2012007846.4","doi-asserted-by":"publisher","DOI":"10.3109\/00016356909026309"},{"key":"2025082804023952000_2013.mar26_1.bcr2012007846.5","doi-asserted-by":"crossref","first-page":"101","DOI":"10.14219\/jada.archive.1970.0151","article-title":"A survey of congenitally missing permanent teeth","volume":"81","author":"Muller","year":"1970","journal-title":"J Am Dent Assoc"},{"key":"2025082804023952000_2013.mar26_1.bcr2012007846.6","first-page":"12","article-title":"The prevalence of malocclusion in Swedis school children","volume":"81","author":"Thilander","year":"1973","journal-title":"Scand J Dent Res"},{"key":"2025082804023952000_2013.mar26_1.bcr2012007846.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1977.tb01635.x"},{"key":"2025082804023952000_2013.mar26_1.bcr2012007846.8","first-page":"365","article-title":"Hypodontia of permanent teeth in Danish school children","volume":"88","author":"Rolling","year":"1980","journal-title":"Scand J Dent Res"},{"key":"2025082804023952000_2013.mar26_1.bcr2012007846.9","first-page":"257","article-title":"Hypodontia in 9\u2005year old Norwegians related to need of orthodontic treatment","volume":"101","author":"Aasheim","year":"1993","journal-title":"Scand J Dent Res"},{"key":"2025082804023952000_2013.mar26_1.bcr2012007846.10","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3109\/00016359709059206","article-title":"Prevalence of malocclusion in 6\u2005year old Icelandic children","volume":"55","author":"Johannsdottir","year":"1997","journal-title":"Acta Odontol Scand"},{"key":"2025082804023952000_2013.mar26_1.bcr2012007846.11","doi-asserted-by":"publisher","DOI":"10.1067\/mod.2002.123948"},{"key":"2025082804023952000_2013.mar26_1.bcr2012007846.12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2004.00158.x"},{"key":"2025082804023952000_2013.mar26_1.bcr2012007846.13","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/S0889-5406(00)70173-9","article-title":"The genetics of human tooth agenesis: new discoveries for understanding dental anomalies","volume":"117","author":"Vastardis","year":"2000","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"2025082804023952000_2013.mar26_1.bcr2012007846.14","doi-asserted-by":"publisher","DOI":"10.1177\/00220345750540011101"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2012-007846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:02:48Z","timestamp":1756378968000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2012-007846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,26]]},"references-count":14,"alternative-id":["10.1136\/bcr-2012-007846"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2012-007846","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,26]]}}}