{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T18:23:48Z","timestamp":1763663028087,"version":"3.40.4"},"reference-count":12,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Imatinib mesylate is a tyrosine kinase inhibitor used widely as the first-line treatment for chronic myeloid leukaemia (CML). The side-effect profile of this drug includes fluid retention, muscle cramps, diarrhoea, myelosuppression and skin rashes. Of these, rashes of the type maculo-papular eruptions and oedema developed most commonly. The cutaneous adverse reactions other than maculo-papular eruptions are rare with imatinib. Severe and life-threatening cutaneous reactions can occur in 5% cases. Here, the author reports a case of newly diagnosed CML that developed Steven-Johnsons syndrome due to imatinib therapy. Patient responded and discharged successfully on withdrawal of the culminating drug.<\/jats:p>","DOI":"10.1136\/bcr-2012-007926","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T10:00:23Z","timestamp":1359021623000},"page":"bcr2012007926","source":"Crossref","is-referenced-by-count":10,"title":["Imatinib-induced Stevens-Johnsons syndrome"],"prefix":"10.1136","volume":"2013","author":[{"given":"Praveen","family":"Jha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himanshu","family":"D","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirdesh","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,1,23]]},"reference":[{"key":"2025042701424153000_2013.jan23_2.bcr2012007926.1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.44"},{"key":"2025042701424153000_2013.jan23_2.bcr2012007926.2","doi-asserted-by":"publisher","DOI":"10.1080\/09546630410015556"},{"key":"2025042701424153000_2013.jan23_2.bcr2012007926.3","first-page":"765","article-title":"Imatinib-induced purpuric vasculitis","volume":"130","author":"Hamm","year":"2003","journal-title":"Ann Dermatol Venereol"},{"key":"2025042701424153000_2013.jan23_2.bcr2012007926.4","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00277-003-0643-z","article-title":"Severe epidermal necrolysis after treatment with imatinib and consecutive allogeneic hematopoietic stem cell transplantation","volume":"82","author":"Schaich","year":"2003","journal-title":"Ann Hematol"},{"key":"2025042701424153000_2013.jan23_2.bcr2012007926.5","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11812"},{"key":"2025042701424153000_2013.jan23_2.bcr2012007926.6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04151_4.x"},{"key":"2025042701424153000_2013.jan23_2.bcr2012007926.7","doi-asserted-by":"publisher","DOI":"10.1159\/000073102"},{"key":"2025042701424153000_2013.jan23_2.bcr2012007926.8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-12-3696"},{"key":"2025042701424153000_2013.jan23_2.bcr2012007926.9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03499.x"},{"key":"2025042701424153000_2013.jan23_2.bcr2012007926.10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-08-2431"},{"key":"2025042701424153000_2013.jan23_2.bcr2012007926.11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.37133.x"},{"key":"2025042701424153000_2013.jan23_2.bcr2012007926.12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200108233450814"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2012-007926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T08:42:47Z","timestamp":1745743367000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2012-007926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,23]]},"references-count":12,"alternative-id":["10.1136\/bcr-2012-007926"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2012-007926","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,1,23]]}}}