{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:40:01Z","timestamp":1756374001874,"version":"3.44.0"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>A 72-year-old male patient with known diffuse cutaneous systemic sclerosis (SSc) presented with severe haemoptysis and blood and protein in the urine. In light of his known interstitial lung disease, he had been repeatedly treated for recurrent community-acquired pneumonia. Immunological testing demonstrated a strongly positive perinuclear antineutrophil cytoplasm antibody with a high titre antimyeloperoxidase antibody. The patient was diagnosed with pulmonary-renal syndrome as a consequence of antineutrophil cytoplasm antibody-associated vasculitis. He started immediate plasmapheresis in combination with methylprednisolone, followed by cyclophosphamide and rituximab, with good clinical outcome.<\/jats:p>","DOI":"10.1136\/bcr-2012-008099","type":"journal-article","created":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T03:12:21Z","timestamp":1371179541000},"page":"bcr2012008099","source":"Crossref","is-referenced-by-count":1,"title":["Antineutrophil cytoplasm antibody-positive pulmonary-renal syndrome in a patient with diffuse cutaneous systemic sclerosis"],"prefix":"10.1136","volume":"2013","author":[{"given":"Lennart","family":"Tonneijck","sequence":"first","affiliation":[{"name":"Division of Medicine, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anisha","family":"Tanna","sequence":"additional","affiliation":[{"name":"Division of Medicine, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles D","family":"Pusey","sequence":"additional","affiliation":[{"name":"Division of Medicine, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,6,13]]},"reference":[{"key":"2025082802210272000_2013.jun13_1.bcr2012008099.1","first-page":"1463","article-title":"Clinical features of systemic sclerosis","volume-title":"Rheumatology","volume":"2013","author":"Wigley","year":"2003"},{"key":"2025082802210272000_2013.jun13_1.bcr2012008099.2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev-pathol-011811-132453","article-title":"Pathogenesis of antineutrophil cytoplasmic autoantibody-associated small-vessel vasculitis","volume":"2013","author":"Jennette","year":"2013","journal-title":"Annu Rev Pathol"},{"key":"2025082802210272000_2013.jun13_1.bcr2012008099.3","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.berh.2010.10.007","article-title":"Epidemiology of systemic sclerosis","volume":"2013","author":"Nikpour","year":"2010","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2025082802210272000_2013.jun13_1.bcr2012008099.4","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.rdc.2010.04.002","article-title":"Epidemiology of ANCA-associated vasculitis","volume":"2013","author":"Ntatsaki","year":"2010","journal-title":"Rheum Dis Clin North Am"},{"key":"2025082802210272000_2013.jun13_1.bcr2012008099.5","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1093\/rheumatology\/ker236","article-title":"Interstitial lung disease and ANCA-associated vasculitis: a retrospective observational cohort study","volume":"2013","author":"Arulkumaran","year":"2011","journal-title":"Rheumatology (Oxford)"},{"key":"2025082802210272000_2013.jun13_1.bcr2012008099.6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.semarthrit.2010.11.001","article-title":"Anti-neutrophil antibody associated vasculitis in systemic sclerosis","volume":"2013","author":"Arad","year":"2011","journal-title":"Semin Arthritis Rheum"},{"key":"2025082802210272000_2013.jun13_1.bcr2012008099.7","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jcrc.2009.04.009","article-title":"Severe respiratory failure due to diffuse alveolar hemorrhage: clinical characteristics and outcome of intensive care","volume":"2013","author":"Rabe","year":"2010","journal-title":"J Crit Care"},{"key":"2025082802210272000_2013.jun13_1.bcr2012008099.8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1055\/s-0031-1279830","article-title":"Management of alveolar hemorrhage in lung vasculitides","volume":"2013","author":"Casian","year":"2011","journal-title":"Semin Respir Crit Care Med"},{"key":"2025082802210272000_2013.jun13_1.bcr2012008099.9","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s00296-010-1697-6","article-title":"Corticosteroids and the risk of scleroderma renal crisis: a systematic review","volume":"2013","author":"Trang","year":"2012","journal-title":"Rheumatol Int"},{"key":"2025082802210272000_2013.jun13_1.bcr2012008099.10","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1093\/ndt\/gfr127","article-title":"Prolonged disease-free remission following rituximab and low-dose cyclophosphamide therapy for renal ANCA associated vasculitis","volume":"2013","author":"Mansfield","year":"2011","journal-title":"Nephrol Dial Transplant"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2012-008099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:21:09Z","timestamp":1756372869000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2012-008099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,13]]},"references-count":10,"alternative-id":["10.1136\/bcr-2012-008099"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2012-008099","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,6,13]]}}}