{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:18:45Z","timestamp":1764173925018,"version":"3.44.0"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>We report the case of a woman who presented cryptogenic temporal lobe seizures from the age of 43\u2005years. Antiepileptic drug (AED) treatment with carbamazepine was able to control seizures for 1\u2005year, but seizures relapsed and an add-on treatment with lamotrigine was started without achieving seizures control. The patient's \u00a0medical history was unremarkable except for a mild hirsutism for which she was taking finasteride since 45\u2005years of age. In view of the possible relationship between finasteride, a known inhibitor of neurosteroids synthesis, and patient's seizures exacerbation, we stopped finasteride resulting in prompt recovery of seizures control. It is know that 5\u03b1-dihydrosteroids are precursors of powerful positive modulators of \u03b3-aminobutyric acid-A \u00a0inhibitory currents and exert antiseizure effects in animal epilepsy models. This case supports the hypothesis that endogenous neurosteroids can modulate seizure susceptibility and response to AEDs also in humans, suggesting their possible use as a new therapeutic option.<\/jats:p>","DOI":"10.1136\/bcr-2012-008204","type":"journal-article","created":{"date-parts":[[2013,2,20]],"date-time":"2013-02-20T00:22:33Z","timestamp":1361319753000},"page":"bcr2012008204","source":"Crossref","is-referenced-by-count":7,"title":["Temporal lobe epilepsy exacerbation during pharmacological inhibition of endogenous neurosteroid synthesis"],"prefix":"10.1136","volume":"2013","author":[{"given":"Matteo","family":"Pugnaghi","sequence":"first","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Monti","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Biagini","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Meletti","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,2,19]]},"reference":[{"key":"2025082703023610000_2013.feb19_1.bcr2012008204.1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nrn1703","article-title":"Neurosteroid: endogenous regulators of the GABA A receptor","volume":"6","author":"Belelli","year":"2005","journal-title":"Nat Neurosci"},{"key":"2025082703023610000_2013.feb19_1.bcr2012008204.2","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/ana.21989","article-title":"Endogenous neurosteroid synthesis modulates seizure frequency","volume":"67","author":"Lawrence","year":"2010","journal-title":"Ann Neurol"},{"doi-asserted-by":"publisher","key":"2025082703023610000_2013.feb19_1.bcr2012008204.3","DOI":"10.1016\/j.eplepsyres.2009.02.017"},{"doi-asserted-by":"publisher","key":"2025082703023610000_2013.feb19_1.bcr2012008204.4","DOI":"10.1038\/nn1469"},{"doi-asserted-by":"publisher","key":"2025082703023610000_2013.feb19_1.bcr2012008204.5","DOI":"10.1016\/j.neuroscience.2010.07.037"},{"doi-asserted-by":"publisher","key":"2025082703023610000_2013.feb19_1.bcr2012008204.6","DOI":"10.1016\/j.expneurol.2006.04.029"},{"doi-asserted-by":"publisher","key":"2025082703023610000_2013.feb19_1.bcr2012008204.7","DOI":"10.1016\/j.yebeh.2012.05.024"},{"doi-asserted-by":"publisher","key":"2025082703023610000_2013.feb19_1.bcr2012008204.8","DOI":"10.1002\/ana.10508"},{"doi-asserted-by":"publisher","key":"2025082703023610000_2013.feb19_1.bcr2012008204.9","DOI":"10.1093\/brain\/awh726"},{"doi-asserted-by":"publisher","key":"2025082703023610000_2013.feb19_1.bcr2012008204.10","DOI":"10.1016\/j.nurt.2006.11.003"},{"doi-asserted-by":"publisher","key":"2025082703023610000_2013.feb19_1.bcr2012008204.11","DOI":"10.1097\/WCO.0b013e32833735cf"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2012-008204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:02:44Z","timestamp":1756288964000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2012-008204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,19]]},"references-count":11,"alternative-id":["10.1136\/bcr-2012-008204"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2012-008204","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,2,19]]}}}