{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T02:46:59Z","timestamp":1771296419857,"version":"3.50.1"},"reference-count":7,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>This case describes the unexpected survival of an adult man who presented to the emergency department with hypovolaemic shock secondary to a splenic haemorrhage. Before surgery he had a pH 6.527, base excess (BE) \u221234.2\u2005mmol\/l and lactate 15.6\u2005mmol\/l. He underwent a splenectomy after which his condition stabilised. He was managed in the intensive care unit postoperatively where he required organ support including renal replacement therapy but was subsequently discharged home with no neurological or renal deficit. Although there are case reports of patients surviving such profound metabolic acidosis these have mainly been cases of near drowning or toxic alcohol ingestion. To the best of our knowledge this is the first reported case of survival after a pH of 6.5 secondary to hypovolaemic shock.<\/jats:p>","DOI":"10.1136\/bcr-2012-008315","type":"journal-article","created":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T23:40:32Z","timestamp":1359589232000},"page":"bcr2012008315","source":"Crossref","is-referenced-by-count":9,"title":["Survival from profound metabolic acidosis due to hypovolaemic shock. A world record?"],"prefix":"10.1136","volume":"2013","author":[{"given":"Nicola","family":"Di Rollo","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Caesar","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A","family":"Ferenbach","sequence":"additional","affiliation":[{"name":"Royal Infirmary of Edinburgh, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J G","family":"Dunn","sequence":"additional","affiliation":[{"name":"Department of Critical Care, Royal Infirmary of Edinburgh, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,1,30]]},"reference":[{"key":"2025082802161455000_2013.jan30_1.bcr2012008315.1","unstructured":"Ganong W . Review of medical physiology. 19th edn. Stamford, CT: Appleton & Lange, 1999."},{"key":"2025082802161455000_2013.jan30_1.bcr2012008315.2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199905000-00003"},{"key":"2025082802161455000_2013.jan30_1.bcr2012008315.3","doi-asserted-by":"publisher","DOI":"10.1186\/cc4963"},{"key":"2025082802161455000_2013.jan30_1.bcr2012008315.4","first-page":"518","article-title":"Is it possible to survive metabolic acidosis with a pH measure of below 6.8? A study of two cases of inedible alcohol intoxication","volume":"68","author":"Kostek","year":"2011","journal-title":"Przeglad Lekarski"},{"key":"2025082802161455000_2013.jan30_1.bcr2012008315.5","first-page":"530","article-title":"Extremely severe metabolic acidosis and multi-organ complications in ethylene glycol intoxication: a case study","volume":"68","author":"Kujawa","year":"2011","journal-title":"Przeglad Lekarski"},{"key":"2025082802161455000_2013.jan30_1.bcr2012008315.6","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199708000-00035"},{"key":"2025082802161455000_2013.jan30_1.bcr2012008315.7","first-page":"116","article-title":"Survival following profound lactic acidosis and cardiac arrest: does metformin really induce lactic acidosis","volume":"10","author":"Spencer","year":"2009","journal-title":"JICS"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2012-008315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:16:22Z","timestamp":1756372582000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2012-008315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,30]]},"references-count":7,"alternative-id":["10.1136\/bcr-2012-008315"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2012-008315","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,30]]}}}