{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:37:11Z","timestamp":1785551831882,"version":"3.56.0"},"reference-count":13,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>A 39-year-old male patient underwent uncomplicated deep anterior lamellar keratoplasty due to keratoconus. On day 5 after surgery, small whitish infiltrates developed in the corneal interface. The diagnosis of fungal keratitis was made when the culture medium of the graft grew <jats:italic>Candida<\/jats:italic> after the surgical intervention. Despite intensive antimycotic treatment and irrigation of the interface, the infiltrates persisted and eventually enlarged. Therefore, revision surgery with penetrating keratoplasty was performed. Microbiological analysis showed <jats:italic>Candida orthopsilosis<\/jats:italic> in the culture of the excised graft button. Histopathological staining of the excised graft showed periodic acid\u2013Schiff-positive and Grocott methenamine silver-positive clusters of yeast between Descemet's membrane and the deep corneal stroma with focal perforations through Descemet's membrane. The treatment of mycotic keratitis caused by <jats:italic>C orthopsilosis<\/jats:italic> is challenging. Antimycotic treatment was unsuccessful in this case. Progression of the keratitis and perforation of Descemet's membrane suggest that early surgical intervention by penetrating keratoplasty is required.<\/jats:p>","DOI":"10.1136\/bcr-2012-008361","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T06:07:14Z","timestamp":1359007634000},"page":"bcr2012008361","source":"Crossref","is-referenced-by-count":25,"title":["Fungal interface keratitis by <i>Candida orthopsilosis<\/i> following deep anterior lamellar keratoplasty"],"prefix":"10.1136","volume":"2013","author":[{"given":"Julia M","family":"Wessel","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Erlangen, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn O","family":"Bachmann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Erlangen, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Meiller","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Erlangen, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich E","family":"Kruse","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Erlangen, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,1,23]]},"reference":[{"key":"2025082801063444000_2013.jan23_3.bcr2012008361.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(01)01181-6"},{"key":"2025082801063444000_2013.jan23_3.bcr2012008361.2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3180ca9a61"},{"key":"2025082801063444000_2013.jan23_3.bcr2012008361.3","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318074e475"},{"key":"2025082801063444000_2013.jan23_3.bcr2012008361.4","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-012-9545-1"},{"key":"2025082801063444000_2013.jan23_3.bcr2012008361.5","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2010.335"},{"key":"2025082801063444000_2013.jan23_3.bcr2012008361.6","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.98723"},{"key":"2025082801063444000_2013.jan23_3.bcr2012008361.7","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31819140c4"},{"key":"2025082801063444000_2013.jan23_3.bcr2012008361.8","first-page":"286","article-title":"Fungal keratitis following excimer laser photorefractive keratectomy","volume":"34","author":"Dunphy","year":"1999","journal-title":"Can J Ophthalmol"},{"key":"2025082801063444000_2013.jan23_3.bcr2012008361.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(03)00217-7"},{"key":"2025082801063444000_2013.jan23_3.bcr2012008361.10","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.1.284-292.2005"},{"key":"2025082801063444000_2013.jan23_3.bcr2012008361.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.02.016"},{"key":"2025082801063444000_2013.jan23_3.bcr2012008361.12","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200301000-00012"},{"key":"2025082801063444000_2013.jan23_3.bcr2012008361.13","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200464180-00001"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2012-008361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:06:41Z","timestamp":1756368401000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2012-008361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,23]]},"references-count":13,"alternative-id":["10.1136\/bcr-2012-008361"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2012-008361","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,23]]}}}