{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:31:15Z","timestamp":1758479475641,"version":"3.40.4"},"reference-count":6,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Susac's syndrome is a microangiopathy of the retina, inner ear and brain manifesting as a triad of encephalopathy, hearing loss and branch retinal artery occlusion. The pathological mechanism is thought to be an immune-mediated small vessel vasculitis with some pathophysiological similarity to dermatomyositis. Awareness and early recognition of this syndrome is important as early treatment with immunosuppression can minimise cognitive, audiological and visual sequelae. We report a case of a 33-year-old woman who presented with the characteristic syndrome. She was treated with immunomodulatory therapy and remains well 2\u2005years postpresentation with no new events.<\/jats:p>","DOI":"10.1136\/bcr-2012-008390","type":"journal-article","created":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T12:33:25Z","timestamp":1376915605000},"page":"bcr2012008390","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Susac's syndrome: an immune mediated endotheliopathy laden with challenges and controversies"],"prefix":"10.1136","volume":"2013","author":[{"given":"Abhishek","family":"Malhotra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Reyneke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merrilee","family":"Needham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,8,19]]},"reference":[{"key":"2025042709044566000_2013.aug19_1.bcr2012008390.1","first-page":"351","article-title":"Susac's syndrome","volume":"2013","author":"Susac","year":"2004","journal-title":"Am J Neuroradiol"},{"key":"2025042709044566000_2013.aug19_1.bcr2012008390.2","doi-asserted-by":"crossref","unstructured":"Henriques IL Bogousslavsky J Caplan LR . Microangiopathy of the retina, inner ear, and brain: Susac's syndrome. In: Caplan LR , ed. In uncommon causes of stroke. 2nd edn. Cambridge University Press, 2008:247\u201354.","DOI":"10.1017\/CBO9780511544897.036"},{"key":"2025042709044566000_2013.aug19_1.bcr2012008390.3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11940-008-0008-y","article-title":"Treatment of Susac's syndrome","volume":"2013","author":"Rennebohm","year":"2008","journal-title":"Curr Treat Options Neurol"},{"key":"2025042709044566000_2013.aug19_1.bcr2012008390.4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jns.2010.07.020","article-title":"Susac's syndrome, a rare, potentially severe or lethal neurological disease","volume":"2013","author":"Saux","year":"2010","journal-title":"J Neurol Sci"},{"key":"2025042709044566000_2013.aug19_1.bcr2012008390.5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.rdc.2009.12.010","article-title":"Gonadal failure with cyclophosphamide therapy for lupus nephritis: advances in fertility preservation","volume":"2013","author":"Mersereau","year":"2010","journal-title":"Rheum Dis Clin North Am"},{"key":"2025042709044566000_2013.aug19_1.bcr2012008390.6","unstructured":"Susac's Syndrome. Clinical Study. University of Calgary [Internet] [cited 18 December, 2012]. http:\/\/www.ucalgary.ca\/susac\/clinicalstudyall"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2012-008390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T16:04:58Z","timestamp":1745769898000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2012-008390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,19]]},"references-count":6,"alternative-id":["10.1136\/bcr-2012-008390"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2012-008390","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,8,19]]}}}